Search Results - "REID, Christopher A"

Spectrum of GABAA receptor variants in epilepsy by Maljevic, Snezana, Møller, Rikke S, Reid, Christopher A, Pérez-Palma, Eduardo, Lal, Dennis, May, Patrick, Lerche, Holger

“…Recent publications point to an increasingly important role of variants in genes encoding GABAA receptor subunits associated with both common and rare forms of…”
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Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death by Richards, Kay L., Milligan, Carol J., Richardson, Robert J., Jancovski, Nikola, Grunnet, Morten, Jacobson, Laura H., Undheim, Eivind A. B., Mobli, Mehdi, Chow, Chun Yuen, Herzig, Volker, Csoti, Agota, Panyi, Gyorgy, Reid, Christopher A., King, Glenn F., Petrou, Steven

“…Dravet syndrome is a catastrophic, pharmacoresistant epileptic encephalopathy. Disease onset occurs in the first year of life, followed by developmental delay…”
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Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD by Reid, Christopher A., Nettesheim, Emily R., Connor, Thomas B., Lipinski, Daniel M.

“…Vascular endothelial growth factor (VEGF) is a key mediator in the development and progression of choroidal neovascularization (CNV) in patients with wet…”
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KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine by Milligan, Carol J., Li, Melody, Gazina, Elena V., Heron, Sarah E., Nair, Umesh, Trager, Chantel, Reid, Christopher A., Venkat, Anu, Younkin, Donald P., Dlugos, Dennis J., Petrovski, Slavé, Goldstein, David B., Dibbens, Leanne M., Scheffer, Ingrid E., Berkovic, Samuel F., Petrou, Steven

“…Objective Mutations in KCNT1 have been implicated in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) and epilepsy of infancy with migrating focal…”
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Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors by Reid, Christopher A, Ertel, Kristina J, Lipinski, Daniel M

“…Effective intravitreal gene delivery to cells of the central retina (i.e., photoreceptors) would be of substantial benefit for treating patients with retinal…”
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GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons by Bryson, Alexander, Hatch, Robert John, Zandt, Bas-Jan, Rossert, Christian, Berkovic, Samuel F., Reid, Christopher A., Grayden, David B., Hill, Sean L., Petrou, Steven

“…The binding of GABA (γ-aminobutyric acid) to extrasynaptic GABAA receptors generates tonic inhibition that acts as a powerful modulator of cortical network…”
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Slc35a2 mosaic knockout impacts cortical development, dendritic arborisation, and neuronal firing by Spyrou, James, Aung, Khaing Phyu, Vanyai, Hannah, Leventer, Richard J., Maljevic, Snezana, Lockhart, Paul J., Howell, Katherine B., Reid, Christopher A.

“…Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an important cause of drug-resistant epilepsy. A significant…”
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Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse by Heighway, Jacqueline, Sedo, Alicia, Garg, Anjali, Eldershaw, Lauren, Perreau, Victoria, Berecki, Géza, Reid, Christopher A., Petrou, Steven, Maljevic, Snezana

“…Genetic variation in voltage-gated sodium (NaV) channels is a significant contributor to neurodevelopmental disorders. NaV channel alpha subunits are encoded…”
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The hyperpolarization‐activated cyclic nucleotide‐gated 4 channel as a potential anti‐seizure drug target by Kharouf, Qays, Phillips, A. Marie, Bleakley, Lauren E., Morrisroe, Emma, Oyrer, Julia, Jia, Linghan, Ludwig, Andreas, Jin, Liang, Nicolazzo, Joseph A., Cerbai, Elisabetta, Romanelli, M. Novella, Petrou, Steven, Reid, Christopher A.

“…Background and Purpose Hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels are encoded by four genes (HCN1–4) with distinct biophysical…”
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Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype by Symeonides, Christos, Vacy, Kristina, Thomson, Sarah, Tanner, Sam, Chua, Hui Kheng, Dixit, Shilpi, Mansell, Toby, O’Hely, Martin, Novakovic, Boris, Herbstman, Julie B., Wang, Shuang, Guo, Jia, Chia, Jessalynn, Tran, Nhi Thao, Hwang, Sang Eun, Britt, Kara, Chen, Feng, Kim, Tae Hwan, Reid, Christopher A., El-Bitar, Anthony, Bernasochi, Gabriel B., Delbridge, Lea M. Durham, Harley, Vincent R., Yap, Yann W., Dewey, Deborah, Love, Chloe J., Burgner, David, Tang, Mimi L. K., Sly, Peter D., Saffery, Richard, Mueller, Jochen F., Rinehart, Nicole, Tonge, Bruce, Vuillermin, Peter, Ponsonby, Anne-Louise, Boon, Wah Chin

“…Male sex, early life chemical exposure and the brain aromatase enzyme have been implicated in autism spectrum disorder (ASD). In the Barwon Infant Study birth…”
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Antidepressant-like activity of a brain penetrant HCN channel inhibitor in mice by Pinares-Garcia, Paulo, Spyrou, James, McKenzie, Chaseley E, Forster, Ian C, Soh, Ming S, Mohamed Syazwan, Erlina, Atif, Mohammed, Reid, Christopher A

“…Changes in Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) channel function have been linked to depressive-like traits, making them potential drug…”
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Preface: Special issue: "Ion channels and genetic epilepsy" by Reid, Christopher A

“…This preface introduces the Journal of Neurochemistry Special Issue on Advances in Epilepsy Research. Epilepsy is a devastating disease characterized by…”
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Reduced dendritic arborization and hyperexcitability of pyramidal neurons in a Scn1b-based model of Dravet syndrome by Reid, Christopher A, Leaw, Bryan, Richards, Kay L, Richardson, Robert, Wimmer, Verena, Yu, Christiaan, Hill-Yardin, Elisa L, Lerche, Holger, Scheffer, Ingrid E, Berkovic, Samuel F, Petrou, Steven

“…Epileptic encephalopathies, including Dravet syndrome, are severe treatment-resistant epilepsies with developmental regression. We examined a mouse model based…”
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Synaptic Zn2+ and febrile seizure susceptibility by Reid, Christopher A, Hildebrand, Michael S, Mullen, Saul A, Hildebrand, Joanne M, Berkovic, Samuel F, Petrou, Steven

“…Zn2+, the second most prevalent trace element in the body, is essential for supporting a wide range of biological functions. While the majority of Zn2+ in the…”
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Epigenetics explained: a topic “primer” for the epilepsy community by the ILAE Genetics/Epigenetics Task Force by Kobow, Katja, Reid, Christopher A., van Vliet, Erwin A., Becker, Albert J., Carvill, Gemma L., Goldman, Alica M., Hirose, Shinichi, Lopes-Cendes, Iscia, Khiari, Hela Mrabet, Poduri, Annapurna, Johnson, Michael R., Henshall, David C.

“…ABSTRACT Epigenetics refers broadly to processes that influence medium to long‐term gene expression by changing the readability and accessibility of the…”
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Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy by Tan, Heneu O, Reid, Christopher A, Single, Frank N, Davies, Philip J, Chiu, Cindy, Murphy, Susan, Clarke, Alison L, Dibbens, Leanne, Krestel, Heinz, Mulley, John C, Jones, Mathew V, Seeburg, Peter H, Sakmann, Bert, Berkovic, Samuel F, Sprengel, Rolf, Petrou, Steven

“…Mutations in the GABAA receptor γ2 subunit are associated with childhood absence epilepsy and febrile seizures. To understand better the molecular basis of…”
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Are Variants Causing Cardiac Arrhythmia Risk Factors in Sudden Unexpected Death in Epilepsy? by Bleakley, Lauren E., Soh, Ming S., Bagnall, Richard D., Sadleir, Lynette G., Gooley, Samuel, Semsarian, Christopher, Scheffer, Ingrid E., Berkovic, Samuel F., Reid, Christopher A.

“…Sudden unexpected death in epilepsy (SUDEP) is the most common cause of premature mortality in individuals with epilepsy. Acute and adaptive changes in heart…”
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Using a Multiplex Nucleic Acid in situ Hybridization Technique to Determine HCN4 mRNA Expression in the Adult Rodent Brain by Oyrer, Julia, Bleakley, Lauren E., Richards, Kay L., Maljevic, Snezana, Phillips, A. Marie, Petrou, Steven, Nowell, Cameron J., Reid, Christopher A.

“…Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels carry a non-selective cationic conductance, Ih, which is important for modulating neuron…”
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Antisense oligonucleotide therapy for KCNT1 encephalopathy by Burbano, Lisseth Estefania, Li, Melody, Jancovski, Nikola, Jafar-Nejad, Paymaan, Richards, Kay, Sedo, Alicia, Soriano, Armand, Rollo, Ben, Jia, Linghan, Gazina, Elena V, Piltz, Sandra, Adikusuma, Fatwa, Thomas, Paul Q, Kopsidas, Helen, Rigo, Frank, Reid, Christopher A, Maljevic, Snezana, Petrou, Steven

“…Developmental and epileptic encephalopathies (DEEs) are characterized by pharmaco-resistant seizures with concomitant intellectual disability. Epilepsy of…”
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Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats by Chern, Kristina J., Nettesheim, Emily R., Reid, Christopher A., Li, Nathan W., Marcoe, Gavin J., Lipinski, Daniel M.

“…Prostaglandin analogs are first-line treatments for open angle glaucoma and while effective at lowering intraocular pressure, they are undermined by patient…”
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