Search Results - "REDWOOD, S"

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy by Toepfer, Christopher N., Garfinkel, Amanda C., Venturini, Gabriela, Wakimoto, Hiroko, Repetti, Giuliana, Alamo, Lorenzo, Sharma, Arun, Agarwal, Radhika, Ewoldt, Jourdan F., Cloonan, Paige, Letendre, Justin, Lun, Mingyue, Olivotto, Iacopo, Colan, Steve, Ashley, Euan, Jacoby, Daniel, Michels, Michelle, Redwood, Charles S., Watkins, Hugh C., Day, Sharlene M., Staples, James F., Padrón, Raúl, Chopra, Anant, Ho, Carolyn Y., Chen, Christopher S., Pereira, Alexandre C., Seidman, Jonathan G., Seidman, Christine E.

“…BACKGROUND:Hypertrophic cardiomyopathy (HCM) is caused by pathogenic variants in sarcomere protein genes that evoke hypercontractility, poor relaxation, and…”
Get full text

Transcatheter aortic valve implantation: current status and future perspectives by Cahill, T J, Chen, M, Hayashida, K, Latib, A, Modine, T, Piazza, N, Redwood, S, Søndergaard, L, Prendergast, B D

“…Abstract In the 16 years since the first pioneering procedure, transcatheter aortic valve implantation (TAVI) has come of age and become a routine strategy for…”
Get full text

Radiation Induced DNA Damage in Operators Performing Endovascular Aortic Repair by El-Sayed, Tamer, Patel, Ashish S, Cho, Jun S, Kelly, James A, Ludwinski, Francesca E, Saha, Prakash, Lyons, Oliver T, Smith, Alberto, Modarai, Bijan

“…BACKGROUND—Radiation exposure during fluoroscopically-guided interventions such as endovascular aortic repair (EVAR) is a growing concern for operators. This…”
Get full text

Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations by Sparrow, Alexander J, Sievert, Kolja, Patel, Suketu, Chang, Yu-Fen, Broyles, Connor N, Brook, Frances A, Watkins, Hugh, Geeves, Michael A, Redwood, Charles S, Robinson, Paul, Daniels, Matthew J

“…RATIONALE:Subcellular Ca indicators have yet to be developed for the myofilament where disease mutation or small molecules may alter contractility through…”
Get full text

Mental stress-induced myocardial ischaemia by Arri, S S, Ryan, M, Redwood, S R, Marber, M S

Get more information

Genetics Matters: Voyaging from the Past into the Future of Humanity and Sustainability by Cheng, Acga, Harikrishna, Jennifer Ann, Redwood, Charles S, Lit, Lei Cheng, Nath, Swapan K, Chua, Kek Heng

“…The understanding of how genetic information may be inherited through generations was established by Gregor Mendel in the 1860s when he developed the…”
Get full text

Governmentality, Geography, and the Geo-Coded World by Rose-Redwood, Reuben S.

“…A growing number of geographers are beginning to explore Foucault’s later work on ‘governmentality’, which examines the relations between the production of…”
Get full text

Molecular Mechanisms of Deregulation of Muscle Contractility Caused by the R168H Mutation in TPM3 and Its Attenuation by Therapeutic Agents by Karpicheva, Olga E, Avrova, Stanislava V, Bogdanov, Andrey L, Sirenko, Vladimir V, Redwood, Charles S, Borovikov, Yurii S

“…The substitution for Arg168His (R168H) in γ-tropomyosin (TPM3 gene, Tpm3.12 isoform) is associated with congenital muscle fiber type disproportion (CFTD) and…”
Get full text

Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7 by Borovikov, Yurii S., Andreeva, Daria D., Avrova, Stanislava V., Sirenko, Vladimir V., Simonyan, Armen O., Redwood, Charles S., Karpicheva, Olga E.

“…Point mutations in the genes encoding the skeletal muscle isoforms of tropomyosin can cause a range of muscle diseases. The amino acid substitution of Arg for…”
Get full text

Mobile digital health devices and the diagnosis in real-time of myocardial ischaemia by Joseph, J P, Redwood, S R

Get full text

Looking for Targets to Restore the Contractile Function in Congenital Myopathy Caused by Gln147Pro Tropomyosin by Karpicheva, Olga E., Simonyan, Armen O., Rysev, Nikita A., Redwood, Charles S., Borovikov, Yurii S.

“…We have used the technique of polarized microfluorimetry to obtain new insight into the pathogenesis of skeletal muscle disease caused by the Gln147Pro…”
Get full text

The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies by Borovikov, Yurii S, Karpicheva, Olga E, Simonyan, Armen O, Avrova, Stanislava V, Rogozovets, Elena A, Sirenko, Vladimir V, Redwood, Charles S

“…Point mutations in genes encoding isoforms of skeletal muscle tropomyosin may cause nemaline myopathy, cap myopathy (Cap), congenital fiber-type disproportion…”
Get full text

Detection of Intracoronary Thrombus by Magnetic Resonance Imaging in Patients With Acute Myocardial Infarction by JANSEN, C. H. P, PERERA, D, REDWOOD, S, BOTNAR, R. M, MAKOWSKI, M. R, WIETHOFF, A. J, PHINIKARIDOU, A, RAZAVI, R. M, MARBER, M. S, GREIL, G. F, NAGEL, E, MAINTZ, D

“…Persistent intracoronary thrombus after plaque rupture is associated with an increased risk of subsequent myocardial infarction and mortality. Coronary…”
Get full text

Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca2+ Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation by Borovikov, Yurii S., Simonyan, Armen O., Avrova, Stanislava V., Sirenko, Vladimir V., Redwood, Charles S., Karpicheva, Olga E.

“…Substitution of Ala for Glu residue in position 173 of γ-tropomyosin (Tpm3.12) is associated with muscle weakness. Here we observe that this mutation increases…”
Get full text

Impact of preprocedural mitral regurgitation upon mortality after transcatheter aortic valve implantation (TAVI) for severe aortic stenosis by Khawaja, M Z, Williams, R, Hung, J, Arri, S, Asrress, K N, Bolter, K, Wilson, K, Young, C P, Bapat, V, Hancock, J, Thomas, M, Redwood, S

“…To identify the effects of preprocedural significant mitral regurgitation (MR) and change in MR severity upon mortality after transcatheter aortic valve…”
Get more information

Pre-procedural pacing bias among transcatheter aortic valves with higher post-procedure pacing rates: evidence from the UK TAVI Registry by Hilling-Smith, R., Smethurst, J., Cockburn, J., Williams, T., Trivedi, U., Banning, A., Redwood, S., de Belder, A., MacCarthy, P., Khogali, S., Blackman, D., Ludman, P., Hildick-Smith, D.

“…Rates of permanent pacemaker (PPM) implantation following transcatheter aortic valve implantation (TAVI) are higher than following surgery and are dependent on…”
Get full text

Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy by Gehmlich, Katja, Dodd, Michael S, Allwood, J William, Kelly, Matthew, Bellahcene, Mohamed, Lad, Heena V, Stockenhuber, Alexander, Hooper, Charlotte, Ashrafian, Houman, Redwood, Charles S, Carrier, Lucie, Dunn, Warwick B

“…Energy depletion has been highlighted as an important contributor to the pathology of hypertrophic cardiomyopathy (HCM), a common inherited cardiac disease…”
Get more information

Vortex formation and recirculation zones in left anterior descending artery stenoses: computational fluid dynamics analysis by Katritsis, D G, Theodorakakos, A, Pantos, I, Andriotis, A, Efstathopoulos, E P, Siontis, G, Karcanias, N, Redwood, S, Gavaises, M

“…Flow patterns may affect the potential of thrombus formation following plaque rupture. Computational fluid dynamics (CFD) were employed to assess hemodynamic…”
Get more information

Diabetes, incretin hormones and cardioprotection by Myat, A, Redwood, S R, Gersh, B J, Yellon, D M, Marber, M S

Get more information

Pre‐dilatation of severely stenotic aortic valves using angioplasty balloons prior to balloon aortic valvuloplasty by Khawaja, M.Z., Thomas, M., Redwood, S.

“…We present a technique that facilitates balloon aortic valvuloplasty in severely stenosed aortic valves through which valvuloplasty balloons are unable to pass…”
Get full text