Search Results - "REDSTON, Mark S"

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma by Aguirre, Andrew J, Bardeesy, Nabeel, Sinha, Manisha, Lopez, Lyle, Tuveson, David A, Horner, James, Redston, Mark S, DePinho, Ronald A

“…Pancreatic ductal adenocarcinoma ranks among the most lethal of human malignancies. Here, we assess the cooperative interactions of two signature mutations in…”
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Examination of Mutations in BRAF, NRAS, and PTEN in Primary Cutaneous Melanoma by Goel, Vikas K., Lazar, Alexander J.F., Warneke, Carla L., Redston, Mark S., Haluska, Frank G.

“…Frequent somatic mutation of v-raf murine sarcoma viral oncogene homolog B (BRAF), a downstream effector of the rat sarcoma oncogene (RAS) signaling pathway,…”
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Is Appendiceal Cancer a Lynch Syndrome-Associated Cancer? by Yurgelun, Matthew B, Papke, Jr, David J, Redston, Mark S

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A mouse to human search for plasma proteome changes associated with pancreatic tumor development by Faca, Vitor M, Song, Kenneth S, Wang, Hong, Zhang, Qing, Krasnoselsky, Alexei L, Newcomb, Lisa F, Plentz, Ruben R, Gurumurthy, Sushma, Redston, Mark S, Pitteri, Sharon J, Pereira-Faca, Sandra R, Ireton, Renee C, Katayama, Hiroyuki, Glukhova, Veronika, Phanstiel, Douglas, Brenner, Dean E, Anderson, Michelle A, Misek, David, Scholler, Nathalie, Urban, Nicole D, Barnett, Matt J, Edelstein, Cim, Goodman, Gary E, Thornquist, Mark D, McIntosh, Martin W, DePinho, Ronald A, Bardeesy, Nabeel, Hanash, Samir M

“…The complexity and heterogeneity of the human plasma proteome have presented significant challenges in the identification of protein changes associated with…”
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Development and evaluation of INT2GRATE: a platform for comprehensive assessment of the role of germline variants informed by tumor signature profile in Lynch syndrome by Isidro, Raymond A., Chittenden, Anu, Walker, McKenzie, Schwartz, Alison, Koeller, Diane R., Hayes, Connor P., Unal, Busra, Manam, Monica Devi, Buehler, Ryan M., Manning, Danielle K., Sholl, Lynette M., Redston, Mark S., Yurgelun, Matthew B., Rana, Huma Q., Garber, Judy E., Ghazani, Arezou A.

“…The presence of variants of uncertain significance (VUS) in DNA mismatch repair (MMR) genes leads to uncertainty in the clinical management of patients being…”
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High-Resolution Characterization of the Pancreatic Adenocarcinoma Genome by Aguirre, Andrew J., Brennan, Cameron, Bailey, Gerald, Sinha, Raktim, Feng, Bin, Leo, Christopher, Zhang, Yunyu, Zhang, Jean, Gans, Joseph D., Bardeesy, Nabeel, Cauwels, Craig, Cordon-Cardo, Carlos, Redston, Mark S., DePinho, Ronald A., Chin, Lynda, Cantley, Lewis C.

“…The pancreatic adenocarcinoma genome harbors multiple amplifications and deletions, pointing to the existence of numerous oncogenes and tumor suppressor genes…”
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Ileal Signet Ring Adenocarcinoma in Crohn’s Disease: Unanticipated Diagnosis After Surgical Resection of a Symptomatic Stricture by Clarke, Lindsay M., Riascos, Maria Christina, Redston, Mark S., Hamilton, Matthew J., Kelly, Colleen R.

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Frequent somatic mutations and homozygous deletions of the p16 ( MTS1 ) gene in pancreatic adenocarcinoma by Caldas, Carlos, Hahn, Stephan A, da Costa, Luis T, Redston, Mark S, Schutte, Mieke, Seymour, Albert B, Weinstein, Craig L, Hruban, Ralph H, Yeo, Charles J, Kern, Scott E

“…The MTS1 gene on chromosome 9p21 encodes the p16 inhibitor of cyclinD/Cdk-4 complexes, and is deleted or mutated in a variety of tumour types. We found allelic…”
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Esophageal squamous cell carcinoma with pagetoid spread: a clinicopathologic study by Miller, Tiffany R, Zhang, Xuchen, Ko, Huaibin M, Lagana, Stephen M, Setia, Namrata, Yassan, Lindsay, Westerhoff, Maria, Deshpande, Vikram, Hornick, Jason L, Redston, Mark S, Zhao, Lei

“…Pagetoid spread in esophageal squamous epithelium associated with underlying esophageal adenocarcinoma (EAC) has been well studied. Case reports describing…”
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Both$p16^{Ink4a}$and the$p19^{Arf}-p53$Pathway Constrain Progression of Pancreatic Adenocarcinoma in the Mouse by Bardeesy, Nabeel, Aguirre, Andrew J., Chu, Gerald C., Cheng, Kuang-hung, Lopez, Lyle V., Hezel, Aram F., Feng, Bin, Brennan, Cameron, Weissleder, Ralph, Mahmood, Umar, Hanahan, Douglas, Redston, Mark S., Chin, Lynda, DePinho, Ronald A.

“…Activating KRAS mutations and$p16^{Ink4a}$inactivation are near universal events in human pancreatic ductal adenocarcinoma (PDAC). In mouse…”
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O6-Methylguanine DNA Methyltransferase Deficiency and Response to Temozolomide-Based Therapy in Patients with Neuroendocrine Tumors by Kulke, Matthew H, Hornick, Jason L, Frauenhoffer, Christine, Hooshmand, Susanne, Ryan, David P, Enzinger, Peter C, Meyerhardt, Jeffrey A, Clark, Jeffrey W, Stuart, Keith, Fuchs, Charles S, Redston, Mark S

“…Purpose: Recent studies suggest that temozolomide has activity in neuroendocrine tumors. Low levels of the DNA repair enzyme, O 6 -methylguanine DNA…”
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Intraductal Papillary Mucinous Neoplasm of the Pancreas With Loss of Mismatch Repair in a Patient With Lynch Syndrome by SPARR, Jennifer A, BANDIPALLIAM, Prathap, REDSTON, Mark S, SYNGAL, Sapna

“…Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a precancerous lesion with a well-described progression to carcinoma. This case report…”
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Successful treatment of cap polyposis with infliximab by Bookman, Ian D, Redston, Mark S, Greenberg, Gordon R

“…Cap polyposis is a disorder characterized by bloody diarrhea with rectosigmoid polyps covered by a cap of fibropurulent exudate. The pathogenesis is unknown,…”
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p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions by REDSTON, M. S, CALDAS, C, SEYMOUR, A. B, HRUBAN, R. H, DA COSTA, L, YEO, C. J, KERN, S. E

“…Pancreatic adenocarcinoma is a major cause of cancer death, and yet little is known about its molecular pathogenesis. We identified p53 mutations in 19 (70%)…”
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Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias by Redston, M S, Papadopoulos, N, Caldas, C, Kinzler, K W, Kern, S E

“…Chronic colitis is associated with an increased risk of colorectal neoplasia, creating a need for early diagnosis in this population. Little is yet known of…”
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Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse by Bardeesy, Nabeel, Aguirre, Andrew J., Chu, Gerald C., Cheng, Kuang-hung, Lopez, Lyle V., Hezel, Aram F., Feng, Bin, Brennan, Cameron, Weissleder, Ralph, Mahmood, Umar, Hanahan, Douglas, Redston, Mark S., Chin, Lynda, DePinho, Ronald A.

“…Activating KRAS mutations and p16 Ink4a inactivation are near universal events in human pancreatic ductal adenocarcinoma (PDAC). In mouse models, Kras G12D…”
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O 6-Methylguanine DNA Methyltransferase Deficiency and Response to Temozolomide-Based Therapy in Patients with Neuroendocrine Tumors by Kulke, Matthew H., Hornick, Jason L., Frauenhoffer, Christine, Hooshmand, Susanne, Ryan, David P., Enzinger, Peter C., Meyerhardt, Jeffrey A., Clark, Jeffrey W., Stuart, Keith, Fuchs, Charles S., Redston, Mark S.

“…Purpose: Recent studies suggest that temozolomide has activity in neuroendocrine tumors. Low levels of the DNA repair enzyme, O6-methylguanine DNA…”
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Development and evaluation of INT 2 GRATE: a platform for comprehensive assessment of the role of germline variants informed by tumor signature profile in Lynch syndrome by Isidro, Raymond A, Chittenden, Anu, Walker, McKenzie, Schwartz, Alison, Koeller, Diane R, Hayes, Connor P, Unal, Busra, Manam, Monica Devi, Buehler, Ryan M, Manning, Danielle K, Sholl, Lynette M, Redston, Mark S, Yurgelun, Matthew B, Rana, Huma Q, Garber, Judy E, Ghazani, Arezou A

“…The presence of variants of uncertain significance (VUS) in DNA mismatch repair (MMR) genes leads to uncertainty in the clinical management of patients being…”
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Allelotype of pancreatic adenocarcinoma using xenograft enrichment by HAHN, S. A, SEYMOUR, A. B, HRUBAN, R. H, KERN, S. E, HOQUE, A. T. M. S, SCHUTTE, M, DA COSTA, L. T, REDSTON, M. S, CALDAS, C, WEINSTEIN, C. L, FISCHER, A, YEO, C. J

“…p53 and MTS1 are known to be mutationally inactivated in pancreatic adenocarcinoma. Other tumor suppressor genes are likely also to play a role. To define…”
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Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia by CALDAS, C, HAHN, S. A, HRUBAN, R. H, REDSTON, M. S, YEO, C. J, KERN, S. E

“…Pancreatic adenocarcinoma is the fifth leading cause of cancer death in the United States. Mutations in the K-ras oncogene occur in 85% of pancreatic…”
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