Search Results - "REDSTON, M"

Association Between Biallelic and Monoallelic Germline MYH Gene Mutations and Colorectal Cancer Risk by Croitoru, Marina E., Cleary, Sean P., Di Nicola, Nando, Manno, Michael, Selander, Teresa, Aronson, Melyssa, Redston, Mark, Cotterchio, Michelle, Knight, Julia, Gryfe, Robert, Gallinger, Steven

“…The MutY human homologue (MYH) gene encodes a member of the base excision repair pathway that is involved in repairing oxidative damage to DNA. Two germline…”
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Frequent somatic mutations and homozygous deletions of the p16 ( MTS1 ) gene in pancreatic adenocarcinoma by Caldas, Carlos, Hahn, Stephan A, da Costa, Luis T, Redston, Mark S, Schutte, Mieke, Seymour, Albert B, Weinstein, Craig L, Hruban, Ralph H, Yeo, Charles J, Kern, Scott E

“…The MTS1 gene on chromosome 9p21 encodes the p16 inhibitor of cyclinD/Cdk-4 complexes, and is deleted or mutated in a variety of tumour types. We found allelic…”
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p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions by REDSTON, M. S, CALDAS, C, SEYMOUR, A. B, HRUBAN, R. H, DA COSTA, L, YEO, C. J, KERN, S. E

“…Pancreatic adenocarcinoma is a major cause of cancer death, and yet little is known about its molecular pathogenesis. We identified p53 mutations in 19 (70%)…”
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Carcinogenesis in the GI Tract: From Morphology to Genetics and Back Again by Redston, Mark

“…The genetic alterations in colorectal cancer progression are determined by one of two separate and distinct underlying pathways of genomic instability. The…”
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Allelotype of pancreatic adenocarcinoma using xenograft enrichment by HAHN, S. A, SEYMOUR, A. B, HRUBAN, R. H, KERN, S. E, HOQUE, A. T. M. S, SCHUTTE, M, DA COSTA, L. T, REDSTON, M. S, CALDAS, C, WEINSTEIN, C. L, FISCHER, A, YEO, C. J

“…p53 and MTS1 are known to be mutationally inactivated in pancreatic adenocarcinoma. Other tumor suppressor genes are likely also to play a role. To define…”
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Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia by CALDAS, C, HAHN, S. A, HRUBAN, R. H, REDSTON, M. S, YEO, C. J, KERN, S. E

“…Pancreatic adenocarcinoma is the fifth leading cause of cancer death in the United States. Mutations in the K-ras oncogene occur in 85% of pancreatic…”
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p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma by DiGiuseppe, JA, Redston, MS, Yeo, CJ, Kern, SE, Hruban, RH

“…The p53 tumor suppressor gene is mutated in the majority of pancreatic adenocarcinomas, and several studies have suggested that loss of p53 function may…”
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MSH2 deficient mice are viable and susceptible to lymphoid tumours by Reitmair, A.H, Schmits, R, Ewel, A, Bapat, B, Redston, M, Mitri, A, Waterhouse, P, Mittrücker, H.-W, Wakeham, A, Liu, B, Thomason, A, Griesser, H, Gallinger, S, Ballhausen, W.G, Fishel, R, Mak, T. W

“…Alterations of the human MSH2 gene, a homologue of the bacterial MutS mismatch repair gene, co-segregate with the majority of hereditary non-polyposis colon…”
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Mismatch Repair Gene Defects Contribute to the Genetic Basis of Double Primary Cancers of the Colorectum and Endometrium by Millar, Anna L., Pal, Tuya, Madlensky, Lisa, Sherman, Chris, Temple, Larissa, Mitri, Angela, Cheng, Hong, Marcus, Victoria, Gallinger, Steven, Redston, Mark, Bapat, Bharati, Narod, Steven

“…Hereditary non-polyposis colorectal cancer (HNPCC) is a dominantly inherited cancer syndrome caused by germline defects of mismatch repair (MMR) genes…”
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p53 Missense Mutations in Microdissected High-Grade Ductal Carcinoma In Situ of the Breast by Done, Susan J., Eskandarian, Sasha, Bull, Shelley, Redston, Mark, Andrulis, Irene L.

“…Background: To understand the role of sporadic mutations in the tumor suppressor gene p53 (also known as TP53) in the pathogenesis of breast cancer, it is…”
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Adenomatous polyps develop commonly in the ileal pouch of patients with familial adenomatous polyposis by Thompson-Fawcett, M W, Marcus, V A, Redston, M, Cohen, Z, Mcleod, R S

“…The aim of this study was to establish the prevalence of adenomatous polyps in the ileal pouch of patients with familial adenomatous polyposis. Forty-three…”
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Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias by Redston, M S, Papadopoulos, N, Caldas, C, Kinzler, K W, Kern, S E

“…Chronic colitis is associated with an increased risk of colorectal neoplasia, creating a need for early diagnosis in this population. Little is yet known of…”
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Klenow co-sequencing: a method for eliminating "stops" by Redston, M S, Kern, S E

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A missense mutation in both hMSH2 and APC in an Ashkenazi Jewish HNPCC kindred: implications for clinical screening by Yuan, Z Q, Wong, N, Foulkes, W D, Alpert, L, Manganaro, F, Andreutti-Zaugg, C, Iggo, R, Anthony, K, Hsieh, E, Redston, M, Pinsky, L, Trifiro, M, Gordon, P H, Lasko, D

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Patients with both pancreatic adenocarcinoma and melanoma may harbor germline CDKN2A mutations by Lal, Geeta, Liu, Ling, Hogg, David, Lassam, Norman J., Redston, Mark S., Gallinger, Steven

“…Germline mutations of the CDKN2A tumor suppressor gene have been identified in melanoma kindreds linked to 9p21, and pancreatic adenocarcinoma is the second…”
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p53 alterations in oesophageal cancer: association with clinicopathological features, risk factors, and survival by Casson, A G, Tammemagi, M, Eskandarian, S, Redston, M, McLaughlin, J, Ozcelik, H

“…AIM: To characterise the spectrum of p53 alterations (gene mutations and protein accumulation) in a consecutive series of surgically resected oesophageal…”
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Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer by Ribic, Christine M, Sargent, Daniel J, Moore, Malcolm J, Thibodeau, Stephen N, French, Amy J, Goldberg, Richard M, Hamilton, Stanley R, Laurent-Puig, Pierre, Gryfe, Robert, Shepherd, Lois E, Tu, Dongsheng, Redston, Mark, Gallinger, Steven

“…In some colorectal cancers, a loss of DNA-repair function causes a defect called microsatellite instability. This study unexpectedly found that adjuvant…”
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Pathology of genetically engineered mouse models of pancreatic exocrine cancer : Consensus report and recommendations by HRUBAN, Ralph H, ADSAY, N. Volkan, KLÖPPEL, Günter, LAUWERS, Gregory Y, LONGNECKER, Daniel S, LÜTTGES, Jutta, MAITRA, Anirban, OFFERHAUS, G. Johan A, PEREZ-GALLEGO, Lucia, REDSTON, Mark, TUVESON, David A, ALBORES-SAAVEDRA, Jorge, ANVER, Miriam R, BIANKIN, Andrew V, BOIVIN, Gregory P, FURTH, Emma E, FURUKAWA, Toru, KLEIN, Alison, KLIMSTIRA, David S

“…Several diverse genetically engineered mouse models of pancreatic exocrine neoplasia have been developed. These mouse models have a spectrum of pathologic…”
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Using genetic information to make surgical decisions: report of a case of a 13-year-old boy with colon cancer by Madlensky, L, Bapat, B, Redston, M, Pearl, R, Gallinger, S, Cohen, Z

“…We report the case of a boy aged 13 years who was diagnosed with a Dukes B obstructing cancer of the sigmoid colon. At the time of diagnosis, he underwent a…”
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Immunohistochemistry Versus Microsatellite Instability Testing in Phenotyping Colorectal Tumors by Lindor, N. M.

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