Search Results - "REDFORD, E. J"

Nitric oxide donors reversibly block axonal conduction : demyelinated axons are especially susceptible by REDFORD, E. J, KAPOOR, R, SMITH, K. J

“…Diseases such as multiple sclerosis and Guillain-Barré syndrome are characterized not only by widespread loss of myelin from nerve fibres, but also by…”
Get full text

Vascular changes and demyelination induced by the intraneural injection of tumour necrosis factor by Redford, E J, Hall, S M, Smith, K J

“…Several observations suggest that tumour necrosis factor (TNF) plays a role in demyelination, although direct evidence for this is lacking. We have examined…”
Get more information

Therapeutic Benefit of a Dissociated Glucocorticoid and the Relevance of In Vitro Separation of Transrepression from Transactivation Activity by Belvisi, Maria G, Wicks, Sharon L, Battram, Clifford H, Bottoms, Stephen E. W, Redford, Jane E, Woodman, Paul, Brown, Thomas J, Webber, Stephen E, Foster, Martyn L

“…Glucocorticoids (GCs) are the mainstay of asthma therapy; however, major side effects limit their therapeutic use. GCs influence the expression of genes either…”
Get full text

A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-α processing attenuates experimental autoimmune neuritis by REDFORD, E. J, SMITH, K. J, GREGSON, N. A, DAVIES, M, HUGHES, P, GEARING, A. J. H, MILLER, K, HUGHES, R. A. C

“…Matrix metalloproteinases (MMPs) and the cytokine tumour necrosis factor (TNF)-alpha are implicated in the pathology of inflammatory demyelinating diseases of…”
Get full text

Matrix metalloproteinase expression during experimental autoimmune neuritis by HUGHES, P. M, WELLS, G. M. A, CLEMENTS, J. M, GEARING, A. J. H, REDFORD, E. J, DAVIES, M, SMITH, K. J, HUGHES, R. A. C, BROWN, M. C, MILLER, K. M

“…Experimental autoimmune neuritis (EAN) is an animal model of Guillain-Barré syndrome. We have shown recently that BB-1101, a broad-spectrum matrix…”
Get full text

Human immunoglobulin ameliorates rat experimental autoimmune neuritis by GABRIEL, C. M, GREGSON, N. A, REDFORD, E. J, DAVIES, M, SMITH, K. J, HUGHES, R. A. C

“…Human immunoglobulin is an effective treatment for Guillain-Barré syndrome, although the mechanism of action is not understood. We have investigated the effect…”
Get full text

RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency by Collis, Alan J, Foster, Martyn L, Halley, Frank, Maslen, Christopher, McLay, Iain M, Page, Kenneth M, Redford, E.Jane, Souness, John E, Wilsher, Nicola E

“…Following the discovery of RPR200765, a series of pyrimidine analogues have been prepared as backups. Amongst them, RPR203494 was identified with a better in…”
Get full text

The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy by MCLAY, Lain M, HALLEY, Frank, FOSTER, Martyn, HELE, David, JAYYOSI, Zaid, KELLEY, Mike, MASLEN, Chris, MILLER, Glen, OULDELHKIM, Marie-Claude, PAGE, Kenneth, PHIPPS, Simon, POLLOCK, Kenneth, SOUNESS, John E, PORTER, Barry, RATCLIFFE, Andrew J, REDFORD, Elisabeth J, WEBBER, Stephen, SLATER, Bryan, THYBAUD, Veronique, WILSHER, Nicola, MCKENNA, Jeffrey, BENNING, Veronique, BIRRELL, Mark, BURTON, Brenda, BELVISI, Maria, COLLIS, Alan, CONSTAN, Alex

“…RPR132331, a 2-(2-dioxanyl)imidazole, was identified as an inhibitor of tumour necrosis factor (TNF)alpha release from lipopolysaccharide (LPS)-stimulated…”
Get full text

Tumour necrosis factor-α has few morphological effects within the dorsal columns of the spinal cord, in contrast to its effects in the peripheral nervous system by Hall, S.M, Redford, E.J, Smith, K.J

“…There is circumstantial evidence implicating the pro-inflammatory cytokine tumour necrosis factor (TNF) in the pathogenesis of multiple sclerosis (MS), but…”
Get full text

Nitric oxide donors reversibily block axonal conduction: Demyelinated axons are especially susceptible by Redford, E J, Kapoor, R, Smith, K J

Get full text

Historical pulse tracings made during anesthesia by Schneider, A J, Redford, J E

Get full text

A compromise for closed system anesthesia by Gorsky, B H, Hall, R L, Redford, J E

“…Closed system anesthesia is economical, minimally, polluting, and conserves a patient's airway heat and moisture. Yet this method of anesthesia is not widely…”
Get full text

Sex differences in anaesthetic toxicity: fluroxene and trifluoroethanol in mice by Cascorbi, H F, Gorsky, B H, Redford, J E

“…A sex difference in postanaesthetic mortality after fluroxene anaesthesia was found in Swiss Webster mice. More males succumbed than females. This toxicity was…”
Get more information

A combined inhibitor of matrix metalloproteinase activity and tumour necrosis (factor-alpha) processing attenuates experimental autoimmune neuritis by Redford, E J, Smith, K J, Gregson, N A, Davies, M

Get full text