Search Results - "REDDY, P."

Mitochondria as a therapeutic target for aging and neurodegenerative diseases by Reddy, P H, Reddy, T P

“…Mitochondria are cytoplasmic organelles responsible for life and death. Extensive evidence from animal models, postmortem brain studies of and clinical studies…”
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Defective mitophagy in Alzheimer’s disease by Pradeepkiran, Jangampalli Adi, Reddy, P. Hemachandra

“…•Healthy mitochondria are essential for functional bioenergetics, cellular functions and balanced homeostasis.•Mitophagy is a cellular process whereby damaged…”
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Mitochondria-targeted catalase reduces abnormal APP processing, amyloid   production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension by Mao, P., Manczak, M., Calkins, M. J., Truong, Q., Reddy, T. P., Reddy, A. P., Shirendeb, U., Lo, H.-H., Rabinovitch, P. S., Reddy, P. H.

“…The purpose of this study was to investigate the protective effects of the mitochondria-targeted antioxidant catalase (MCAT) and lifespan extension in mice…”
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Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage by SHIRENDEB, Ulziibat, REDDY, Arubala P, MANCZAK, Maria, CALKINS, Marcus J, PEIZHONG MAO, TAGLE, Danilo A, HEMACHANDRA REDDYL, P

“…The purpose of our study was to determine the relationship between mutant huntingtin (Htt) and mitochondrial dynamics in the progression of Huntington's…”
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Amyloid Beta in Aging and Alzheimer's Disease by Sehar, Ujala, Rawat, Priyanka, Reddy, Arubala P, Kopel, Jonathan, Reddy, P Hemachandra

“…Alzheimer's disease (AD), is a progressive neurodegenerative disease that affects behavior, thinking, learning, and memory in elderly individuals. AD occurs in…”
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Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease by MANCZAK, Maria, HEMACHANDRA REDDY, P

“…The purpose of our study was to determine the relationship between voltage-dependent anion channel 1 protein (VDAC1) and amyloid beta (Aβ) and phosphorylated…”
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Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics by Reddy, P. Hemachandra, Tripathi, Raghav, Troung, Quang, Tirumala, Karuna, Reddy, Tejaswini P., Anekonda, Vishwanath, Shirendeb, Ulziibat P., Calkins, Marcus J., Reddy, Arubala P., Mao, Peizhong, Manczak, Maria

“…Synaptic pathology and mitochondrial oxidative damage are early events in Alzheimer's disease (AD) progression. Loss of synapses and synaptic damage are the…”
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Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria by John, Albin, Reddy, P. Hemachandra

“…•Alzheimer’s disease (AD) is a progressive and synaptic failure disease.•Synaptic pathology and mitochondrial oxidative damage are early events in Alzheimer’s…”
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Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease by Reddy, P Hemachandra, Yin, XiangLing, Manczak, Maria, Kumar, Subodh, Pradeepkiran, Jangampalli Adi, Vijayan, Murali, Reddy, Arubala P

“…Abstract The purpose of our study was to determine the toxic effects of hippocampal mutant APP (mAPP) and amyloid beta (Aβ) in human mAPP complementary DNA…”
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Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage by MANCZAK, Maria, HEMACHANDRA REDDY, P

“…We recently reported increased mitochondrial fission and decreased fusion, increased amyloid beta (Aβ) interaction with the mitochondrial fission protein Drp1,…”
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Novel MicroRNA-455-3p and its protective effects against abnormal APP processing and amyloid beta toxicity in Alzheimer's disease by Kumar, Subodh, Reddy, Arubala P., Yin, Xiangling, Reddy, P. Hemachandra

“…The purpose of our study is to understand the protective role of miR-455-3p against abnormal amyloid precursor protein (APP) processing, amyloid beta (Aβ)…”
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Protective effects of mitophagy enhancers against amyloid beta-induced mitochondrial and synaptic toxicities in Alzheimer disease by Kshirsagar, Sudhir, Sawant, Neha, Morton, Hallie, Reddy, Arubala P, Reddy, P Hemachandra

“…Abstract The purpose of our study is to determine the protective effects of mitophagy enhancers against mutant APP and amyloid beta (Aβ)-induced mitochondrial…”
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Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity by Manczak, Maria, Kandimalla, Ramesh, Yin, Xiangling, Reddy, P Hemachandra

“…Abstract The purpose of our study was to better understand the effects of mitochondrial-division inhibitor 1 (Mdivi-1) on mitochondrial fission, mitochondrial…”
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Recent advances in photocatalytic treatment of pollutants in aqueous media by Reddy, P. Anil Kumar, Reddy, P. Venkata Laxma, Kwon, Eilhann, Kim, Ki-Hyun, Akter, Tahmina, Kalagara, Sudhakar

“…Photocatalysis can be an excellent solution for resolving the world's energy and environmental problems. It has a wide range of applications for the…”
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Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease by Pugazhenthi, Subbiah, Qin, Limei, Reddy, P. Hemachandra

“…Cognitive decline in chronic diabetic patients is a less investigated topic. Diabetes and obesity are among the modifiable risk factors for Alzheimer's disease…”
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A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease by Reddy, P. Hemachandra, Tonk, Sahil, Kumar, Subodh, Vijayan, Murali, Kandimalla, Ramesh, Kuruva, Chandra Sekhar, Reddy, Arubala P.

“…Currently, 5.4 million Americans suffer from AD, and these numbers are expected to increase up to 16 million by 2050. Despite tremendous research efforts, we…”
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Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer’s disease by Reddy, Arubala P, Yin, Xiangling, Sawant, Neha, Reddy, P Hemachandra

“…Abstract The purpose of this study is to study the neuroprotective role of selective serotonin reuptake inhibitor (SSRI), citalopram, against Alzheimer’s…”
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Emerging role of non‐coding RNA in health and disease by Bhatti, Gurjit Kaur, Khullar, Naina, Sidhu, Inderpal Singh, Navik, Uma Shanker, Reddy, Arubala P., Reddy, P. Hemachandra, Bhatti, Jasvinder Singh

“…Human diseases have always been a significant turf of concern since the origin of mankind. It is cardinal to know the cause, treatment, and cure for every…”
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Are circulating microRNAs peripheral biomarkers for Alzheimer's disease? by Kumar, Subodh, Reddy, P. Hemachandra

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss, multiple cognitive abnormalities and intellectual…”
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Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension by PEIZHONG MAO, MANCZAK, Maria, CALKINS, Marcus J, TRUONG, Quang, REDDY, Tejaswini P, REDDY, Arubala P, SHIRENDEB, Ulziibat, LO, Herng-Hsiang, RABINOVITCH, Peter S, HEMACHANDRA REDDY, P

“…The purpose of this study was to investigate the protective effects of the mitochondria-targeted antioxidant catalase (MCAT) and lifespan extension in mice…”
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