Search Results - "REDDY, Joseph A"

The folate receptor as a rational therapeutic target for personalized cancer treatment by Assaraf, Yehuda G, Leamon, Christopher P, Reddy, Joseph A

“…Abstract Conventional cancer treatment modalities have several limitations including lack of sufficient efficacy, serious untoward toxicity, as well as innate…”
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Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic by Reddy, Joseph A., Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Kleindl, Paul, Santhapuram, Hari, Vlahov, Iontcho R., Leamon, Christopher P.

“…EC1456 is a folate-tubulysin conjugate constructed with an all-D enantiomeric spacer/linker configuration. When tested against folate receptor (FR)-positive…”
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Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent by Reddy, Joseph A., Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Johnson, Theresa, Cross, Vicky, Westrick, Elaine, Qi, LongWu, Hahn, Spencer, Santhapuram, Hari Krishna, Parham, Garth, Wang, Kevin, Vaughn, Jeremy F., Felten, Albert, Pugh, Michael, Lu, June, Klein, Patrick, Vlahov, Iontcho R., Leamon, Christopher P.

“…Folate receptor (FR)-targeted small molecule drug conjugates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizing…”
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Preclinical evaluation of EC145, a folate-Vinca alkaloid conjugate by REDDY, Joseph A, DORTON, Ryan, WESTRICK, Elaine, DAWSON, Alicia, SMITH, Terri, XU, Le-Cun, VETZEL, Marilynn, KLEINDL, Paul, VLAHOV, Iontcho R, LEAMON, Christopher P

“…We recently developed a new group of folate-conjugated Vinca alkaloids, one of which, EC145, emerged as a candidate for clinical development. Brief treatment…”
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Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery by Paulos, Chrystal M, Reddy, Joseph A, Leamon, Christopher P, Turk, Mary Jo, Low, Philip S

“…Folate receptor-targeted cancer therapies constitute a promising treatment for the approximately one third of human cancers that overexpress the folate…”
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Impact of high and low folate diets on tissue folate receptor levels and antitumor responses toward folate-drug conjugates by Leamon, Christopher P, Reddy, Joseph A, Dorton, Ryan, Bloomfield, Alicia, Emsweller, Kristen, Parker, Nikki, Westrick, Elaine

“…Herein, we present a detailed analysis on the effects of feeding laboratory mice both high and low folic acid (folate)-containing diets as related to…”
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Targeting Folate Receptors to Treat Invasive Urinary Bladder Cancer by DHAWAN, Deepika, RAMOS-VARA, Jose A, REDDY, Joseph A, KOCH, Michael, MURPHY, Linda, FOUREZ, Lindsey M, STEWART, Jane C, KNAPP, Deborah W, NAUGHTON, James F, LIANG CHENG, LOW, Philip S, ROTHENBUHLER, Ryan, LEAMON, Christopher P, PARKER, Nikki, KLEIN, Patrick J, VLAHOV, Lontcho R

“…Folate receptors (FR) may be of use for targeted delivery of cytotoxic drugs in invasive urothelial carcinoma (iUC), for which improved therapy is needed. FR…”
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High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide by Guertin, Amy D, O'Neil, Jennifer, Stoeck, Alexander, Reddy, Joseph A, Cristescu, Razvan, Haines, Brian B, Hinton, Marlene C, Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Vetzel, Marilynn, Lejnine, Serguei, Nebozhyn, Michael, Zhang, Theresa, Loboda, Andrey, Picard, Kristen L, Schmidt, Emmett V, Dussault, Isabelle, Leamon, Christopher P

“…Targeting surface receptors overexpressed on cancer cells is one way to specifically treat cancer versus normal cells. Vintafolide (EC145), which consists of…”
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Comparative preclinical activity of the folate‐targeted Vinca alkaloid conjugates EC140 and EC145 by Leamon, Christopher P., Reddy, Joseph A., Vlahov, Iontcho R., Westrick, Elaine, Parker, Nikki, Nicoson, Jeffrey S., Vetzel, Marilynn

“…EC140 is a water soluble folate conjugate of desacetylvinblastine monohydrazide (DAVLBH), which is constructed with an endosome‐cleavable acyl hydrazone bond…”
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Surface modification technique to enhance metallurgical and mechanical properties of alloy C-276 weldment by laser shock peening without coating by Nithin Joseph Reddy, S A, Thrinadh, E, Prabhakaran, S, Kalainathan, S, Arivazhagan, N, Manikandan, M

“…Microsegregation of alloying elements is prone to hot cracking in the weldment of alloy C-276. The formation of topologically close packed phases P and µ is…”
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Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate–targeted immunotherapy in hapten-immunized mice by Lu, Yingjuan, Xu, Le-Cun, Parker, Nikki, Westrick, Elaine, Reddy, Joseph A, Vetzel, Marilynn, Low, Philip S, Leamon, Christopher P

“…Folic acid (pteroylglutamic acid) represents a useful ligand for targeted cancer therapies because it binds to a common epithelial tumor antigen known as the…”
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An Assembly Concept for the Consecutive Introduction of Unsymmetrical Disulfide Bonds:  Synthesis of a Releasable Multidrug Conjugate of Folic Acid by Vlahov, Iontcho R, Santhapuram, Hari Krishna R, Wang, Yu, Kleindl, Paul J, You, Fei, Howard, Stephen J, Westrick, Elaine, Reddy, Joseph A, Leamon, Christopher P

“…We describe the development of methodology which allows for the introduction of a second disulfide bond into a molecular framework with a pre-existing…”
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Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate by Leamon, Christopher P, Reddy, Joseph A, Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Vetzel, Marilynn, Kleindl, Paul, Hahn, Spencer, Wang, Kevin, Vlahov, Iontcho R

“…Prostate-specific membrane antigen (PSMA) is a biomarker that is overexpressed on prostate cancer, and it is also present on the neovasculature within many…”
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Folate-targeted chemotherapy by Leamon, Christopher P, Reddy, Joseph A

“…The folate receptor (FR) is a confirmed tumor-associated antigen that binds folate and folate–drug conjugates with very high affinity and shuttles these bound…”
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Rational Combination Therapy of Vintafolide (EC145) with Commonly Used Chemotherapeutic Drugs by REDDY, Joseph A, DORTON, Ryan, BLOOMFIELD, Alicia, NELSON, Melissa, VETZEL, Marilynn, GUAN, John, LEAMON, Christopher P

“…When evaluated in patients with ovarian and other cancer, vintafolide (EC145), a potent folate-targeted vinca alkaloid conjugate, displayed a toxicity profile…”
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Folate–Vinca Alkaloid Conjugates for Cancer Therapy: A Structure–Activity Relationship by Leamon, Christopher P, Vlahov, Iontcho R, Reddy, Joseph A, Vetzel, Marilynn, Santhapuram, Hari Krishna R, You, Fei, Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Kleindl, Paul, Vaughn, Jeremy F, Westrick, Elaine

“…Vintafolide is a potent folate-targeted vinca alkaloid small molecule drug conjugate (SMDC) that has shown promising results in multiple clinical oncology…”
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Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue by Leamon, Christopher P, Reddy, Joseph A, Vetzel, Marilynn, Dorton, Ryan, Westrick, Elaine, Parker, Nikki, Wang, Yu, Vlahov, Iontcho

“…The membrane-bound high-affinity folate receptor (FR) is highly expressed on a wide range of primary and metastatic human cancers, such as those originating in…”
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Detecting Functional and Accessible Folate Receptor Expression in Cancer and Polycystic Kidneys by Chu, Haiyan, Shillingford, Jonathan M, Reddy, Joseph A, Westrick, Elaine, Nelson, Melissa, Wang, Emilia Z, Parker, Nikki, Felten, Albert E, Vaughn, Jeremy F, Xu, Le-Cun, Lu, Yingjuan J, Vlahov, Iontcho R, Leamon, Christopher P

“…Folate-based small molecule drug conjugates (SMDCs) are currently under development and have shown promising preclinical and clinical results against various…”
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Abstract 3754: Pre-clinical studies of a highly potent folate receptor targeted DNA crosslinking agent by Reddy, Joseph A., Nelson, Melissa, Johnson, Theresa, Dirksen, Christina, Vetzel, Marilynn, Hahn, Spencer, Qi, LongWu, Vlahov, Iontcho, Leamon, Christopher

“…Abstract Folate receptor (FR) targeted small molecule drug conjugates (SMDC) have shown promising results in early stage clinical trials with Vintafolide and…”
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Enhancing the therapeutic range of a targeted small-molecule tubulysin conjugate for folate receptor-based cancer therapy by Leamon, Christopher P., Reddy, Joseph A., Vlahov, Iontcho R., Dorton, Ryan, Bloomfield, Alicia, Vetzel, Marilynn, Klein, Patrick J., Westrick, Elaine, Xu, Le-cun, Wang, Yu

“…Purpose EC0305 represents a folate-tubulysin B construct capable of specifically eradicating folate receptor (FR)-positive subcutaneous tumors from mice…”
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