Search Results - "REDDY, E. P"

Progenitor/Stem Cells Give Rise to Liver Cancer Due to Aberrant TGF-β and IL-6 Signaling by Tang, Yi, Kitisin, Krit, Jogunoori, Wilma, Li, Cuiling, Deng, Chu-Xia, Mueller, Susette C., Ressom, Habtom W., Rashid, Asif, He, Aiwu Ruth, Mendelson, Jonathan S., Jessup, John M., Shetty, Kirti, Zasloff, Michael, Mishra, Bibhuti, Reddy, E. P., Johnson, Lynt, Mishra, Lopa

“…Cancer stem cells (CSCs) are critical for the initiation, propagation, and treatment resistance of multiple cancers. Yet functional interactions between…”
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Correction: critical interactions between TGF-β signaling/ELF, and E-cadherin/β-catenin mediated tumor suppression by Katuri, V., Tang, Y., Li, C., Jogunoori, W., Deng, C.-X., Rashid, A., Sidawy, A. N., Evans, S., Reddy, E. P., Mishra, B., Mishra, L.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41388-020-01632-1…”
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Family history of hematologic malignancies and risk of multiple myeloma: differences by race and clinical features by VanValkenburg, MaryAnn E., Pruitt, Gwendolyn I., Brill, Ilene K., Costa, Luciano, Ehtsham, Maryam, Justement, Ian T., Innis-Shelton, Racquel D., Salzman, Donna, Reddy, E. Shyam P., Godby, Kelly N., Mikhail, Fady M., Carroll, Andrew J., Reddy, Vishnu B., Sanderson, Ralph D., Justement, Louis B., Sanders, Paul W., Brown, Elizabeth E.

“…Purpose Multiple myeloma (MM) is the most common hematologic malignancy affecting Blacks in the USA, with standardized incidence rates that are twofold to…”
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Disruption of transforming growth factor-β signaling through β-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation by KITISIN, K, GANESAN, N, MENDELSON, J, ZASLOFF, M, RASHID, A, FISHBEIN, T, EVANS, S. R. T, SIDAWY, A, REDDY, E. P, MISHRA, B, JOHNSON, L. B, SHETTY, K, TANG, Y, MISHRA, L, JOGUNOORI, W, VOLPE, E. A, KIM, S. S, KATURI, V, KALLAKURY, B, PISHVAIAN, M, ALBANESE, C

“…Transforming growth factor-beta (TGF-beta) signaling members, TGF-beta receptor type II (TBRII), Smad2, Smad4 and Smad adaptor, embryonic liver fodrin (ELF),…”
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Liver Stem Cells and Hepatocellular Carcinoma by MISHRA, Lopa, BANKER, Tanuj, MURRAY, Joseph, BYERS, Stephen, THENAPPAN, Arun, HE, Aiwu Ruth, SHETTY, Kirti, JOHNSON, Lynt, REDDY, E. P

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Styryl sulfonyl compounds inhibit translation of cyclin D1 in mantle cell lymphoma cells by Prasad, A, Park, I-W, Allen, H, Zhang, X, Reddy, M V R, Boominathan, R, Reddy, E P, Groopman, J E

“…Mantle cell lymphoma (MCL) is characterized by the uncontrolled overexpression of cyclin D1. Styryl sulfonyl compounds have shown potent antitumor activity…”
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JNK signaling in apoptosis by Dhanasekaran, D N, Reddy, E P

“…Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate…”
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Janus kinases: components of multiple signaling pathways by Rane, S G, Reddy, E P

“…Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal transduction pathways that govern cellular survival, proliferation,…”
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Celecoxib and a novel COX-2 inhibitor ON09310 upregulate death receptor 5 expression via GADD153 CHOP by He, Q, Luo, X, Jin, W, Huang, Y, Reddy, M V R, Reddy, E P, Sheikh, M S

“…Cyclooxygenase-2 (COX-2) inhibitors are promising anticancer agents but their long-term use at high doses is associated with adverse cardiovascular events. The…”
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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia by Dubus, Pierre, Mettus, Richard V, Boden, Guenther, Rane, Sushil G, Galbreath, Elizabeth J, Barbacid, Mariano, Reddy, E. Premkumar

“…To ascertain the role of cyclin-dependent kinase 4 (Cdk4) in vivo, we have targeted the mouse Cdk4 locus by homologous recombination to generate two strains of…”
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ETS-Related Gene Activation Preserves Adherens Junctions and Permeability in Microvascular Endothelial Cells by Tharakan, Binu, Hunter, Felicia A., Muthusamy, Saravanakumar, Randolph, Sonya, Byrd, Crystal, Rao, Veena N., Reddy, E Shyam P., Childs, Ed. W.

“…ERG (ETS-related gene) is a member of the ETS (Erythroblast-transformation specific) family of transcription factors abundantly present in vascular endothelial…”
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Evaluation of the novel mitotic modulator ON 01910.Na in pancreatic cancer and preclinical development of an ex vivo predictive assay by Jimeno, A, Chan, A, Cusatis, G, Zhang, X, Wheelhouse, J, Solomon, A, Chan, F, Zhao, M, Cosenza, S C, Reddy, MV Ramana, Rudek, M A, Kulesza, P, Donehower, R C, Reddy, E P, Hidalgo, M

“…The pupose of this study was to evaluate the activity of ON 01910.Na, a mitotic inhibitor, in in vitro and in vivo models of pancreatic cancer and to discover…”
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Critical interactions between TGF-β signaling/ELF, and E-cadherin/β-catenin mediated tumor suppression by KATURI, V, TANG, Y, MISHRA, L, LI, C, JOGUNOORI, W, DENG, C.-X, RASHID, A, SIDAWY, A. N, EVANS, S, REDDY, E. P, MISHRA, B

“…Inactivation of the transforming growth factor-beta (TGF-beta) pathway occurs often in malignancies of the gastrointestinal (GI) system. However, only a…”
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Liver stem cells and hepatocellular carcinoma by Mishra, Lopa, Banker, Tanuj, Murray, Joseph, Byers, Stephen, Thenappan, Arun, He, Aiwu Ruth, Shetty, Kirti, Johnson, Lynt, Reddy, E. P.

“…Although the existence of cancer stem cells (CSCs) was first proposed over 40 years ago, only in the past decade have these cells been identified in…”
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Hematopoietic cytokine receptor signaling by Baker, S J, Rane, S G, Reddy, E P

“…Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are mediated by cytokines and their receptors. Proper culmination of…”
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CDK4: A Key Player in the Cell Cycle, Development, and Cancer by Baker, Stacey J, Reddy, E Premkumar

“…The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type…”
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BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers by YULI, C, SHAO, N, RAO, V. N, RAO, R, AYSOLA, P, REDDY, V, OPREA-ILIES, G, LEE, L, OKOLI, J, PARTRIDGE, E, REDDY, E. S. P

“…Breast cancer gene 1 (BRCA1) mutations predispose women to breast and ovarian cancers and men to increased risks for prostate cancer. We have previously showed…”
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Granulocyte colony-stimulating factor-induced upregulation of Jak3 transcription during granulocytic differentiation is mediated by the cooperative action of Sp1 and Stat3 by MANGAN, J. K, TANTRAVAHI, R. V, RANE, S. G, REDDY, E. P

“…We previously demonstrated that Jak3 is a primary response gene for G-CSF and ectopic overexpression of Jak3 can accelerate granulocytic differentiation of…”
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Evaluation of novel cell cycle inhibitors in mantle cell lymphoma by PARK, I.-W, REDDY, M. V. R, REDDY, E. P, GROOPMAN, J. E

“…Signature abnormalities in the cell cycle and apoptotic pathway have been identified in mantle cell lymphoma (MCL), affording the opportunity to develop…”
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Scaffold proteins of MAP-kinase modules by Dhanasekaran, D N, Kashef, K, Lee, C M, Xu, H, Reddy, E P

“…Mitogen-activated protein kinases (MAPKs) regulate critical signaling pathways involved in cell proliferation, differentiation and apoptosis. Recent studies…”
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