Search Results - "REDDANNA, P"

In vitro evaluation of anticancer effects of different probiotic strains on HCT‐116 cell line by Yenuganti, V.R., Yadala, R., Azad, R., Singh, S., Chiluka, V., Ahire, J., Reddanna, P.

“…Aim Since the evolution of man, microbes are associated with humans, playing a vital role in the maintenance of good health. However, an imbalance in the gut…”
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Free energy calculations to estimate ligand-binding affinities in structure-based drug design by Reddy, M Rami, Reddy, C Ravikumar, Rathore, R S, Erion, Mark D, Aparoy, P, Reddy, R Nageswara, Reddanna, P

“…Post-genomic era has led to the discovery of several new targets posing challenges for structure-based drug design efforts to identify lead compounds. Multiple…”
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Managing SARS-CoV2 Infections Through Resolution of Inflammation by Eicosanoids: A Review by Mohammed, Ameena, Kalle, Arunasree M, Reddanna, Pallu

“…Severe Corona Virus Disease is characterized by angiocentric inflammation of lungs and cytokine storm leading to potentially fatal multiple organ failure…”
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Advances in binding free energies calculations: QM/MM-based free energy perturbation method for drug design by Rathore, R S, Sumakanth, M, Reddy, M Siva, Reddanna, P, Rao, Allam Appa, Erion, Mark D, Reddy, M R

“…Multiple approaches have been devised and evaluated to computationally estimate binding free energies. Results using a recently developed Quantum Mechanics…”
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Evaluation of Cissus quadrangularis extracts as an inhibitor of COX, 5-LOX, and proinflammatory mediators by Bhujade, Arti M., Talmale, Suhas, Kumar, Naresh, Gupta, Geetika, Reddanna, P., Das, Samar K., Patil, M.B.

“…Cissus quadrangularis is an ancient medicinal plant. It is an active ingredient of one Ayurvedic formula called “Laksha Gogglu”. Its stem is used in food…”
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Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro by Subhashini, J., Mahipal, S.V.K., Reddanna, P.

“…Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is the only non-steroidal anti-inflammatory drug so far which has been approved by the FDA for…”
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Role of environmental estrogens in the deterioration of male factor fertility by Rozati, Roya, Reddy, P P, Reddanna, P, Mujtaba, Rubina

“…To evaluate the role of the environmental estrogens polychlorinated biphenyls (PCBs) and phthalate esters (PEs) as potential environmental hazards in the…”
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Anti-leukemic effects of gallic acid on human leukemia K562 cells: Downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation by Chandramohan Reddy, T., Bharat Reddy, D., Aparna, A., Arunasree, Kalle M., Gupta, Geetika, Achari, Chandrani, Reddy, G.V., Lakshmipathi, V., Subramanyam, A., Reddanna, P.

“…[Display omitted] ► The present study examined the mechanisms by which GA causes cell death. ► GA inhibited cell proliferation in various cancer cell lines. ►…”
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Selective Inhibition of Cyclooxygenase-2 by C-Phycocyanin, a Biliprotein from Spirulina platensis by Reddy, C.Madhava, Bhat, Vadiraja B., Kiranmai, G., Reddy, M.Narsa, Reddanna, P., Madyastha, K.M.

“…We report data from two related assay systems (isolated enzyme assays and whole blood assays) that C-phycocyanin a biliprotein from Spirulina platensis is a…”
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Anti-angiogenic effect of chebulagic acid involves inhibition of the VEGFR2- and GSK-3β-dependent signaling pathways by Athira, A P, Abhinand, C S, Saja, K, Helen, A, Reddanna, P, Sudhakaran, P R

“…Inhibition of angiogenesis is a useful strategy to prevent cancer growth by targeting new vessels that grow to nourish actively proliferating tumor cells…”
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Computer aided drug design approaches to develop cyclooxygenase based novel anti-inflammatory and anti-cancer drugs by Reddy, R N, Mutyala, Ravichandra, Aparoy, P, Reddanna, P, Reddy, M Rami

“…Cyclooxygenases (COXs), the enzymes involved in the formation of prostaglandins from polyunsaturated fatty acids such as arachidonic acid, exist in two…”
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Effect of 15-lipoxygenase metabolites on angiogenesis: 15(S)-HPETE is angiostatic and 15(S)-HETE is angiogenic by Soumya, Sasikumar J., Binu, Sheela, Helen, A., Anil Kumar, K., Reddanna, P., Sudhakaran, Perumana R.

“…Objective 15( S )-Hydroxyeicosatetraenoic acid [15( S )-HETE] and 15( S )-hydroperoxyeicosatetraenoic acid [15( S )-HPETE] are the products of arachidonic acid…”
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CoMFA and CoMSIA studies on 5-hydroxyindole-3-carboxylate derivatives as 5-lipoxygenase inhibitors: Generation of homology model and docking studies by Aparoy, P., Suresh, G.K., Kumar Reddy, K., Reddanna, P.

“…In this Letter, CoMFA and CoMSIA were performed on a series of 2-substituted 5-hydroxyindole-3-carboxylate derivatives as potent 5-LOX inhibitors. The data…”
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Identification and evaluation of antioxidant, analgesic/anti-inflammatory activity of the most active ninhydrin–phenol adducts synthesized by Prabhakar, K.R., Veerapur, V.P., Bansal, Punit, Vipan, K. Parihar, Reddy, K.M., Barik, Atanu, Reddy, Bharat Kumar D., Reddanna, P., Priyadarsini, K.I., Unnikrishnan, M.K.

“…Phenol–ninhydrin adducts were synthesized and the best free radical scavenger, lipoxgenase inhibitor was identified and studied for its in vivo analgesic,…”
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C-Phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages by Reddy, Madhava C, Subhashini, J, Mahipal, S.V.K, Bhat, Vadiraja B, Srinivas Reddy, P, Kiranmai, G, Madyastha, K.M, Reddanna, P

“…C-Phycocyanin (C-PC) is one of the major biliproteins of Spirulina platensis, a blue green algae, with antioxidant and radical scavenging properties. It is…”
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Homology modeling of 5-lipoxygenase and hints for better inhibitor design by Aparoy, P., Reddy, R. N., Guruprasad, Lalitha, Reddy, M. R., Reddanna, P.

“…Lipoxygenases (LOXs) are a group of enzymes involved in the oxygenation of polyunsaturated fatty acids. Among these 5-lipoxygenase (5-LOX) is the key enzyme…”
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Does glutathione S-transferase Pi (GST-Pi) a marker protein for cancer? by Aliya, S, Reddanna, P, Thyagaraju, K

“…Glutathione S-transferases (GSTs, EC 2.5.1.18) are multifunctional and multigene products. They are versatile enzymes and participate in the nucleophilic…”
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Fulminant hepatic failure in rats induces oxidative stress differentially in cerebral cortex, cerebellum and pons medulla by Sathyasaikumar, K V, Swapna, I, Reddy, P V B, Murthy, Ch R K, Dutta Gupta, A, Senthilkumaran, B, Reddanna, P

“…Hepatic Encephalopathy (HE) is one of the most common complications of acute liver diseases and is known to have profound influence on the brain. Most of the…”
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Pharmacophore modeling and virtual screening for designing potential 5-Lipoxygenase inhibitors by Aparoy, P., Kumar Reddy, K., Kalangi, Suresh K., Chandramohan Reddy, T., Reddanna, P.

“…In this Letter, we identified pharmacophore model of the 5-LOX inhibitors. Then the best quantitative pharmacophore model generated was used as a 3D query to…”
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Minimum MD simulation length required to achieve reliable results in free energy perturbation calculations: Case study of relative binding free energies of fructose-1,6-bisphosphatase inhibitors by Rathore, R.S., Aparoy, P., Reddanna, P., Kondapi, A. K., Rami Reddy, M.

“…In an attempt to establish the criteria for the length of simulation to achieve the desired convergence of free energy calculations, two studies were carried…”
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