Search Results - "REASON, Donald C"

Complement-Mediated Bactericidal Activity of Anti-Factor H Binding Protein Monoclonal Antibodies against the Meningococcus Relies upon Blocking Factor H Binding by GIUNTINI, Serena, REASON, Donald C, GRANOFF, Dan M

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Combined Roles of Human IgG Subclass, Alternative Complement Pathway Activation, and Epitope Density in the Bactericidal Activity of Antibodies to Meningococcal Factor H Binding Protein by Giuntini, Serena, Reason, Donald C, Granoff, Dan M

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Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity by Giuntini, Serena, Beernink, Peter T, Reason, Donald C, Granoff, Dan M

“…Meningococcal factor H binding protein (fHbp) is a promising vaccine candidate. Anti-fHbp antibodies can bind to meningococci and elicit complement-mediated…”
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Erratum: A Broadly Cross-Reactive Monoclonal Antibody Against an Epitope on the N-terminus of Meningococcal fHbp by Vu, David M., Pajon, Rolando, Reason, Donald C., Granoff, Dan M.

“…Meningococcal factor H binding protein (fHbp) is an important vaccine antigen for prevention of disease caused by capsular group B strains. The protein has…”
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Somatic Hypermutation and Diverse Immunoglobulin Gene Usage in the Human Antibody Response to the Capsular Polysaccharide of Streptococcus pneumoniae Type 6B by JIANHUI ZHOU, LOTTENBACH, Kathleen R, BARENKAMP, Stephen J, REASON, Donald C

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Recurrent Variable Region Gene Usage and Somatic Mutation in the Human Antibody Response to the Capsular Polysaccharide of Streptococcus pneumoniae Type 23F by Zhou, Jianhui, Lottenbach, Kathleen R, Barenkamp, Stephen J, Lucas, Alexander H, Reason, Donald C

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Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires by Reason, Donald C, Zhou, Jianhui

“…It has been suggested that codon insertion and/or deletion may represent a mechanism that, along with hypermutation, contributes to the affinity maturation of…”
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A Broadly Cross-Reactive Monoclonal Antibody Against an Epitope on the N-terminus of Meningococcal fHbp by Vu, David M., Pajon, Rolando, Reason, Donald C., Granoff, Dan M.

“…Meningococcal factor H binding protein (fHbp) is an important vaccine antigen for prevention of disease caused by capsular group B strains. The protein has…”
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Combinatorial Library Cloning of Human Antibodies to Streptococcus pneumoniae Capsular Polysaccharides: Variable Region Primary Structures and Evidence for Somatic Mutation of Fab Fragments Specific for Capsular Serotypes 6B, 14, and 23F by LUCAS, Alexander H, MOULTON, Karen D, TANG, Vanessa R, REASON, Donald C

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Somatic diversity in CDR3 loops allows single V-genes to encode innate immunological memories for multiple pathogens by Thomson, Christy A, Little, Ken Q, Reason, Donald C, Schrader, John W

“…The human Ab response to many common pathogens is oligoclonal, with restricted usage of Ig V-genes. Intriguingly, the IGVK3-11 and IGVH3-30 V-genes are…”
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Domain specificity of the human antibody response to Bacillus anthracis protective antigen by Reason, Donald C, Ullal, Anuska, Liberato, Justine, Sun, Jinying, Keitel, Wendy, Zhou, Jianhui

“…Abstract Protective antigen (PA) is the cell surface recognition moiety of the Bacillus anthracis A-B toxin system, and the active immunogenic component in the…”
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Comment on "Engineering antibody heavy chain CDR3 to create a phage display Fab library rich in antibodies that bind charged carbohydrates" by Lucas, Alexander H, Reason, Donald C

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Paratope diversity in the human antibody response to Bacillus anthracis protective antigen by Zhou, Jianhui, Ullal, Anuska, Liberato, Justine, Sun, Jinying, Keitel, Wendy, Reason, Donald C.

“…The active component of the licensed human anthrax vaccine (BioThrax™, or AVA) is a Bacillus anthracis toxin known as protective antigen (PA). Second…”
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Correlation of antigenic epitope and antibody gene usage in the human immune response to Streptococcus pneumoniae type 23F capsular polysaccharide by Reason, Donald C, Zhou, Jianhui

“…The human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F is predominated by antibodies which express either VκL6 or…”
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Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type b polysaccharide: expression of canonical variable regions and their variants in vaccinated infants by Lucas, Alexander H, McLean, Gary R, Reason, Donald C, O’Connor, Adam P, Felton, Mistique C, Moulton, Karen D

“…A structurally conserved antibody combining site, encoded by the IGH V3-23 and kappa A2 variable (V) region gene segments, predominates the adult immune…”
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T lymphocyte proliferative responses induced by recombinant factor VIII in hemophilia A patients with inhibitors by Singer, S T, Addiego, Jr, J E, Reason, D C, Lucas, A H

“…In this study we sought to determine whether factor VIII-reactive T lymphocytes were present in hemophilia A patients with inhibitor antibodies. Peripheral…”
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Polysaccharide Binding Potential of the Human A2 or A18 Kappa Light Chain Homologues by REASON, D. C, WAGNER, T. C, TANG, V. R, MOULTON, K. D, LUCAS, A. H

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Domain specificity of the human antibody response toBacillus anthracisprotective antigen by Reason, Donald C, Ullal, Anuska, Liberato, Justine, Sun, Jinying, Keitel, Wendy, Zhou, Jianhui

“…Protective antigen (PA) is the cell surface recognition moiety of theBacillus anthracisA-B toxin system, and the active immunogenic component in the currently…”
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Polysaccharide vaccines as probes of antibody repertoires in man by Lucas, Alexander H., Reason, Donald C.

“…Antibodies specific for capsular polysaccharide epitopes mediate immunity to encapsulated bacterial pathogens, and accordingly, vac‐cine development has…”
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Somatic Hypermutation and Diverse Immunoglobulin Gene Usage in the Human Antibody Response to the Capsular Polysaccharide of S treptococcus pneumoniae Type 6B by Zhou, Jianhui, Lottenbach, Kathleen R., Barenkamp, Stephen J., Reason, Donald C.

“…ABSTRACT Combinatorial cloning and expression library analysis were used to determine the expressed human antibody repertoire specific for the capsular…”
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