Search Results - "REASON, D. C"

Combinatorial Library Cloning of Human Antibodies to Streptococcus pneumoniae Capsular Polysaccharides: Variable Region Primary Structures and Evidence for Somatic Mutation of Fab Fragments Specific for Capsular Serotypes 6B, 14, and 23F by LUCAS, Alexander H, MOULTON, Karen D, TANG, Vanessa R, REASON, Donald C

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Aging and the immune response to the Haemophilus influenzae type b capsular polysaccharide : Retention of the dominant idiotype and antibody function in the elderly by LUCAS, A. H, REASON, D. C

“…Anti-Haemophilus influenzae b polysaccharide (Hib PS) antibodies elicited in elderly subjects following conjugate vaccination expressed a light-chain…”
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Human Fab fragments specific for the Haemophilus influenzae b polysaccharide isolated from a bacteriophage combinatorial library use variable region gene combinations and express an idiotype that mirrors in vivo expression by REASON, D. C, CHARIS WAGNER, T, LUCAS, A. H

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Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide by LUCAS, A. H, LARRICK, J. W, REASON, D. C

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T lymphocyte proliferative responses induced by recombinant factor VIII in hemophilia A patients with inhibitors by Singer, S T, Addiego, Jr, J E, Reason, D C, Lucas, A H

“…In this study we sought to determine whether factor VIII-reactive T lymphocytes were present in hemophilia A patients with inhibitor antibodies. Peripheral…”
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Somatic Hypermutation and Diverse Immunoglobulin Gene Usage in the Human Antibody Response to the Capsular Polysaccharide of Streptococcus pneumoniae Type 6B by JIANHUI ZHOU, LOTTENBACH, Kathleen R, BARENKAMP, Stephen J, REASON, Donald C

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Recurrent Variable Region Gene Usage and Somatic Mutation in the Human Antibody Response to the Capsular Polysaccharide of Streptococcus pneumoniae Type 23F by Zhou, Jianhui, Lottenbach, Kathleen R, Barenkamp, Stephen J, Lucas, Alexander H, Reason, Donald C

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Polysaccharide Binding Potential of the Human A2 or A18 Kappa Light Chain Homologues by REASON, D. C, WAGNER, T. C, TANG, V. R, MOULTON, K. D, LUCAS, A. H

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Induction of a protective human polysaccharide-specific antibody response in hu-PBL SCID mice by idiotypic vaccination by Reason, DC, Kitamura, MY, Lucas, AH

“…The human Ab repertoire to the Haemophilus influenzae type b (Hib) polysaccharide (PS) is dominated by Abs that use the kappa II-A2 VL region and that express…”
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Polysaccharide vaccines as probes of antibody repertoires in man by Lucas, Alexander H., Reason, Donald C.

“…Antibodies specific for capsular polysaccharide epitopes mediate immunity to encapsulated bacterial pathogens, and accordingly, vac‐cine development has…”
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A murine hybridoma with large cytoplasmic inclusions of κ light chains by REASON, D. C

“…A murine hybridoma cell line has been established that consistently forms large cytoplasmic inclusions. These structures bind antibody specific for mouse kappa…”
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Correlation of antigenic epitope and antibody gene usage in the human immune response to Streptococcus pneumoniae type 23F capsular polysaccharide by Reason, Donald C, Zhou, Jianhui

“…The human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F is predominated by antibodies which express either VκL6 or…”
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Extracellular ATP stimulates interleukin-dependent cultured mast cells and eosinophils through calcium mobilization by Saito, H, Ebisawa, M, Reason, D C, Ohno, K, Kurihara, K, Sakaguchi, N, Ohgimi, A, Saito, E, Akasawa, A, Akimoto, K

“…We examined the effect of ATP and related nucleotides on the changes in intracellular calcium ([Ca2+]i) in murine bone marrow-derived mast cells (BMMC) and…”
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Interleukin 4 induces CD4+/CD8- to CD8+/CD4- transformation of human neonatal T cells by way of a double positive intermediate by Reason, D C, Ebisawa, M, Saito, H, Nagakura, T, Iikura, Y

“…We have determined that IL-4 induces the generation of CD4+/CD8+ T cells in cultures of neonatal lymphocytes. Sorting, positive, and negative selection…”
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Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type b polysaccharide: expression of canonical variable regions and their variants in vaccinated infants by Lucas, Alexander H, McLean, Gary R, Reason, Donald C, O’Connor, Adam P, Felton, Mistique C, Moulton, Karen D

“…A structurally conserved antibody combining site, encoded by the IGH V3-23 and kappa A2 variable (V) region gene segments, predominates the adult immune…”
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Human cord blood lymphocytes do not simultaneously express CD4 and CD8 cell surface markers by Reason, D C, Ebisawa, M, Saito, H, Nagakura, T, Iikura, Y

“…Several authors have reported finding significant numbers of immature T lymphocytes of the CD4/CD8 'double positive' phenotype in human cord blood. We have…”
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Role of kappa II-A2 light chain CDR-3 junctional residues in human antibody binding to the Haemophilus influenzae type b polysaccharide by Lucas, A H, Moulton, K D, Reason, D C

“…Abs using the kappaII-A2 V gene segment predominate the human Ab repertoire to the Haemophilus influenzae b (Hib) polysaccharide (PS). All A2 anti-Hib PS Abs…”
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Interleukin 4-mediated induction of CD4+/CD8+ T cells during infancy by Ebisawa, M, Reason, D C, Saito, H, Nakano, S, Seo, K, Kawamura, K, Iikura, Y

“…Neonatal human CD4+ T cells will co-express CD8 on their surface following short-term culture with interleukin 4 (IL-4). Adult T cells do not respond in this…”
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Structural determinants of the human idiotype HibId-1 by Reason, Donald C., O'Connor, Adam P., Lucas, Alexander H.

“…The human antibody response to the capsular polysaccharide of Haemophilus influenzae type b is predominated by antibodies expressing a light‐chain‐associated…”
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Functional expression of the IGKV A18b gene and its idiotypic cross-reactivity with the A2 variable region by Reason, D C, Lucas, A H

“…The number of functional human immunoglobulin kappa variable (IGKV) genes varies considerably between individuals, since polymorphisms exist which extend from…”
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