Search Results - "READ, M. L"

Manipulation of PBF/PTTG1IP Phosphorylation Status; a Potential New Therapeutic Strategy for Improving Radioiodine Uptake in Thyroid and Other Tumors by Smith, V. E, Sharma, N, Watkins, R. J, Read, M. L, Ryan, G. A, Kwan, P. P, Martin, A, Watkinson, J. C, Boelaert, K, Franklyn, J. A, McCabe, C. J

“…Context: The clinical effectiveness of ablative radioiodine treatment of thyroid tumors is limited by the availability of the sodium iodide symporter (NIS) at…”
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Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery by DASH, P. R, READ, M. L, BARRETT, L. B, WOLFERT, M. A, SEYMOUR, L. W

“…Self-assembling polycation/DNA complexes represent a promising synthetic vector for gene delivery. However, despite considerable versatility and transfectional…”
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PTTG-Binding Factor (PBF) Is a Novel Regulator of the Thyroid Hormone Transporter MCT8 by Smith, V. E, Read, M. L, Turnell, A. S, Sharma, N, Lewy, G. D, Fong, J. C. W, Seed, R. I, Kwan, P, Ryan, G, Mehanna, H, Chan, S. Y, Darras, V. M, Boelaert, K, Franklyn, J. A, McCabe, C. J

“…Within the basolateral membrane of thyroid follicular epithelial cells, two transporter proteins are central to thyroid hormone (TH) biosynthesis and…”
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Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer by Read, M L, Fong, J C, Modasia, B, Fletcher, A, Imruetaicharoenchoke, W, Thompson, R J, Nieto, H, Reynolds, J J, Bacon, A, Mallick, U, Hackshaw, A, Watkinson, J C, Boelaert, K, Turnell, A S, Smith, V E, McCabe, C J

“…The proto-oncogene PTTG and its binding partner PBF have been widely studied in multiple cancer types, particularly thyroid and colorectal, but their combined…”
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Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF by Imruetaicharoenchoke, W, Fletcher, A, Lu, W, Watkins, R J, Modasia, B, Poole, V L, Nieto, H R, Thompson, R J, Boelaert, K, Read, M L, Smith, V E, McCabe, C J

“…Pituitary tumor-transforming gene 1-binding factor (PTTG1IP; PBF) is a multifunctional glycoprotein, which is overexpressed in a wide range of tumours, and…”
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The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer by READ, M. L, CLARK, A. R, DOCHERTY, K

“…Two important sequence elements, designated insulin enhancer binding site 1 (IEB1) or NIR and IEB2 or FAR, are involved in regulating expression of the rat…”
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CTb targeted non-viral cDNA delivery enhances transgene expression in neurons by Barrett, L. B., Berry, M., Ying, W.-B., Hodgkin, M. N., Seymour, L. W., Gonzalez, A.-M., Read, M. L., Baird, A., Logan, A.

“…Background Efficient neuronal gene therapy is a goal for the long‐term repair and regeneration of the injured central nervous system (CNS). We investigated…”
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The emerging role of pituitary tumour transforming gene (PTTG) in endocrine tumourigenesis by Kim, D.S., Fong, J., Read, M.L., McCabe, C.J.

“…It is now 10 years since PTTG was first cloned and isolated. Perhaps the major story of the intervening decade of work performed by numerous groups around the…”
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Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells by Bettinger, T, Carlisle, R C, Read, M L, Ogris, M, Seymour, L W

“…Synthetic vectors were evaluated for their ability to mediate efficient mRNA transfection. Initial results indicated that lipoplexes, but not polyplexes based…”
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Systemic circulation of poly(l-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy by Ward, Christopher M., Read, Martin L., Seymour, Leonard W.

“…Effective gene therapy for diseases of the circulation requires vectors capable of systemic delivery. The molecular weight of poly(l-lysine) (pLL) has a…”
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Arthroscopic treatment of osteochondritis dissecans of the capitellum by Brownlow, Harry C, O'Connor-Read, Laurence M, Perko, Mark

“…The results of arthroscopic debridement and loose body retrieval for osteochondritis dissecans (OCD) of the capitellum in 29 symptomatic patients who had…”
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Factors Influencing the Ability of Nuclear Localization Sequence Peptides To Enhance Nonviral Gene Delivery by Bremner, K. Helen, Seymour, Leonard W, Logan, Ann, Read, Martin L

“…Nonviral gene delivery is limited by inefficient transfer of DNA from the cytoplasm to the nucleus. Nuclear localization sequence (NLS) peptides have been…”
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Vectors based on reducible polycations facilitate intracellular release of nucleic acids by Read, Martin L., Bremner, K. Helen, Oupický, David, Green, Nicola K., Searle, Peter F., Seymour, Leonard W.

“…Background Inefficient intracellular delivery of nucleic acids limits the therapeutic usefulness of synthetic vectors such as poly(L‐lysine) (PLL)/DNA…”
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Regulation of insulin gene transcription by nutrients by Docherty, K, Macfarlane, W M, Read, M L, Smith, S B, Wilson, M E, Bujalska, I, Gilligan, M

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Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin by Dash, Philip R., Read, Martin L., Fisher, Kerry D., Howard, Kenneth A., Wolfert, Margreet, Oupicky, David, Subr, Vladimir, Strohalm, Jiri, Ulbrich, Karel, Seymour, Leonard W.

“…Binding of serum proteins to polyelectrolyte gene delivery complexes is thought to be an important factor limiting bloodstream circulation and restricting…”
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Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner by MacFarlane, W M, Read, M L, Gilligan, M, Bujalska, I, Docherty, K

“…In the human insulin gene, three regulatory sequences upstream of the transcription start site at -77 (the CT1 box), -210 (the CT2 box), and -315 (the CT3 box)…”
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A novel cis-acting element required for lipopolysaccharide-induced transcription of the murine interleukin-1 beta gene by Godambe, Sandip A., Chaplin, David D., Takova, Tsetska, Read, Lory M., Bellone, Clifford J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA by Howard, Kenneth A., Dash, Philip R., Read, Martin L., Ward, Kim, Tomkins, Lesley M., Nazarova, Ola, Ulbrich, Karel, Seymour, Leonard W.

“…To investigate the possibility of producing charge-neutral gene delivery complexes with extended, non-particulate structures, DNA was allowed to self-assemble…”
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Enhanced gene transfer activity of peptide-targeted gene-delivery vectors by Parker, Alan L., Fisher, Kerry D., Oupicky, David, Read, Martin L., Nicklin, Stuart A., Baker, Andrew H., Seymour, Leonard W.

“…We have evaluated the capacity of the cell-binding heptapeptide SIGYPLP to enhance transgene expression using non-viral and viral gene delivery vectors…”
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Characterisation of the binding interaction between poly( L-lysine) and DNA using the fluorescamine assay in the preparation of non-viral gene delivery vectors by Read, Martin L., Etrych, Thomas, Ulbrich, Karel, Seymour, Leonard W.

“…A major factor limiting the development of non-viral gene delivery systems is the poor characterisation of polyelectrolyte complexes formed between cationic…”
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