Search Results - "RAYMAN, Patricia"

Active surveillance in metastatic renal-cell carcinoma: a prospective, phase 2 trial by Rini, Brian I, Prof, Dorff, Tanya B, MD, Elson, Paul, ScD, Rodriguez, Cristina Suarez, MD, Shepard, Dale, MD, Wood, Laura, MSN, Humbert, Jordi, BSc, Pyle, Linda, RN, Wong, Yu-Ning, MD, Finke, James H, Prof, Rayman, Patricia A, MS, Larkin, James M G, FRCP, Garcia, Jorge A, MD, Plimack, Elizabeth R, MD

“…Summary Background A subset of patients with metastatic renal-cell carcinoma show indolent growth of metastases. Because of the toxicity and non-curative…”
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Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients by KO, Jennifer S, ZEA, Arnold H, DREICER, Robert, BUKOWSKI, Ronald, FINKE, James H, RINI, Brian I, IRELAND, Joanna L, ELSON, Paul, COHEN, Peter, GOLSHAYAN, Ali, RAYMAN, Patricia A, WOOD, Laura, GARCIA, Jorge

“…Purpose: Immune dysfunction reported in renal cell carcinoma (RCC) patients may contribute to tumor progression. Myeloid-derived suppressor cells (MDSC)…”
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Cancer Stem Cell‐Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion by Otvos, Balint, Silver, Daniel J., Mulkearns‐Hubert, Erin E., Alvarado, Alvaro G., Turaga, Soumya M., Sorensen, Mia D., Rayman, Patricia, Flavahan, William A, Hale, James S., Stoltz, Kevin, Sinyuk, Maksim, Wu, Qiulian, Jarrar, Awad, Kim, Sung‐Hak, Fox, Paul L., Nakano, Ichiro, Rich, Jeremy N., Ransohoff, Richard M., Finke, James, Kristensen, Bjarne W., Vogelbaum, Michael A., Lathia, Justin D.

“…Shifting the balance away from tumor‐mediated immune suppression toward tumor immune rejection is the conceptual foundation for a variety of immunotherapy…”
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Sunitinib Reverses Type-1 Immune Suppression and Decreases T-Regulatory Cells in Renal Cell Carcinoma Patients by FINKE, James H, RINI, Brian, BUKOWSKI, Ronald, IRELAND, Joanna, RAYMAN, Patricia, RICHMOND, Amy, GOLSHAYAN, Ali, WOOD, Laura, ELSON, Paul, GARCIA, Jorge, DREICER, Robert

“…Purpose: Immune dysfunction is well documented in renal cell carcinoma (RCC) patients and likely contributes to tumor evasion. This dysfunction includes a…”
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Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma by Raychaudhuri, Baisakhi, Rayman, Patricia, Ireland, Joanna, Ko, Jennifer, Rini, Brian, Borden, Ernest C., Garcia, Jorge, Vogelbaum, Michael A., Finke, James

“…To assess the accumulation of myeloid-derived suppressor cells (MDSCs) in the peripheral blood of patients with glioma and to define their heterogeneity and…”
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Direct and Differential Suppression of Myeloid-Derived Suppressor Cell Subsets by Sunitinib Is Compartmentally Constrained by KO, Jennifer S, RAYMAN, Patricia, IRELAND, Joanna, SWAIDANI, Shadi, GEQIANG LI, BUNTING, Kevin D, RINI, Brian, FINKE, James H, COHEN, Peter A

“…The antiangiogenic drug sunitinib is a receptor tyrosine kinase inhibitor with significant, yet not curative, therapeutic effects in metastatic renal cell…”
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Phase II Clinical Trial of Pembrolizumab and Chemotherapy Reveals Distinct Transcriptomic Profiles by Radiologic Response in Metastatic Triple-Negative Breast Cancer by Wilkerson, Avia D, Parthasarathy, Prerana Bangalore, Stabellini, Nickolas, Mitchell, Carley, Pavicic, Jr, Paul G, Fu, Pingfu, Rupani, Amit, Husic, Hana, Rayman, Patricia A, Swaidani, Shadi, Abraham, Jame, Budd, G Thomas, Moore, Halle, Al-Hilli, Zahraa, Ko, Jennifer S, Baar, Joseph, Chan, Timothy A, Alban, Tyler, Diaz-Montero, C Marcela, Montero, Alberto J

“…A single arm, phase II trial of carboplatin, nab-paclitaxel, and pembrolizumab (CNP) in metastatic triple-negative breast cancer (mTNBC) was designed to…”
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Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection by Das Sarma, Jayasri, Burrows, Amy, Rayman, Patricia, Hwang, Mi-Hyun, Kundu, Soumya, Sharma, Nikhil, Bergmann, Cornelia, Sen, Ganes C

“…The interferon-induced tetratricopeptide repeat protein (Ifit2) protects mice from lethal neurotropic viruses. Neurotropic coronavirus MHV-RSA59 infection of…”
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Immunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression by Pavicic, Paul G., Rayman, Patricia A., Swaidani, Shadi, Rupani, Amit, Makarov, Vladimir, Tannenbaum, Charles S., Edwards, Robert P., Vlad, Anda M., Diaz-Montero, C. Marcela, Mahdi, Haider

“…The tumor microenvironment (TME) in ovarian cancer (OC) is characterized by immune suppression, due to an abundance of suppressive immune cells populations. To…”
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Talimogene Laherparepvec combined with anti-PD-1 based immunotherapy for unresectable stage III-IV melanoma: a case series by Sun, Lillian, Funchain, Pauline, Song, Jung Min, Rayman, Patricia, Tannenbaum, Charles, Ko, Jennifer, Mcnamara, Michael, Marcela Diaz-Montero, C, Gastman, Brian

“…Talimogene Laherparepvec (T-VEC) is an oncolytic virus approved as an intratumoral therapy for treating unresectable stage IIIB-IV metastatic melanoma. The…”
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Unfolded Protein Response Differentially Regulates TLR4-Induced Cytokine Expression in Distinct Macrophage Populations by Zhang, Lei, Pavicic, Jr, Paul G, Datta, Shyamasree, Song, Qiaoling, Xu, Xiaohan, Wei, Wei, Su, Fan, Rayman, Patricia A, Zhao, Chenyang, Hamilton, Thomas

“…Cellular stress responses are often engaged at sites of inflammation and can alter macrophage cytokine production. We now report that macrophages in distinct…”
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Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer by Zamanian-Daryoush, Maryam, Lindner, Daniel J, DiDonato, Joseph A, Wagner, Matthew, Buffa, Jennifer, Rayman, Patricia, Parks, John S, Westerterp, Marit, Tall, Alan R, Hazen, Stanley L

“…Increased circulating levels of apolipoprotein A-I (apoA-I), the major protein of high-density lipoprotein (HDL), by genetic manipulation or infusion, protects…”
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Evaluation of T cell infiltration in matched biopsy and nephrectomy samples in renal cell carcinoma by Zahoor, Haris, Pavicic, Paul G., Przybycin, Christopher, Ko, Jennifer, Stephens, Lisa, Radivoyevitch, Tomas, Jia, Xuefei, Diaz-Montero, Claudia Marcela, Finke, James, Rayman, Patricia A., Gilligan, Timothy D., Grivas, Petros, Ornstein, Moshe, Garcia, Jorge A., Rini, Brian I.

“…T cell infiltration in tumors has been investigated as a biomarker of response to checkpoint inhibitors. Neo-adjuvant studies in renal cell carcinoma (RCC) may…”
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GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway by Mahata, Barun, Biswas, Soumika, Rayman, Patricia, Chahlavi, Ali, Ko, Jennifer, Bhattacharjee, Ashish, Li, Yu-Teh, Li, Yuntao, Das, Tanya, Sa, Gaurisankar, Raychaudhuri, Baisakhi, Vogelbaum, Michael A, Tannenbaum, Charles, Finke, James H, Biswas, Kaushik

“…Previously we demonstrated that human glioblastoma cell lines induce apoptosis in peripheral blood T cells through partial involvement of secreted…”
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Immunological Correlates of Response to Immune Checkpoint Inhibitors in Metastatic Urothelial Carcinoma by Tzeng, Alice, Diaz-Montero, C. Marcela, Rayman, Patricia A., Kim, Jin S., Pavicic, Paul G., Finke, James H., Barata, Pedro C., Lamenza, Marcelo, Devonshire, Sarah, Schach, Kim, Emamekhoo, Hamid, Ernstoff, Marc S., Hoimes, Christopher J., Rini, Brian I., Garcia, Jorge A., Gilligan, Timothy D., Ornstein, Moshe C., Grivas, Petros

“…Background The identification of prognostic and/or predictive biomarkers for response to immune checkpoint inhibitors (ICI) could help guide treatment…”
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GD3, an Overexpressed Tumor-Derived Ganglioside, Mediates the Apoptosis of Activated but not Resting T Cells by SA, Gaurisankar, DAS, Tanya, MOON, Christina, HILSTON, Cynthia M, RAYMAN, Patricia A, RINI, Brian I, TANNENBAUM, Charles S, FINKE, James H

“…We previously elucidated an important role for gangliosides in renal cell carcinoma-mediated T lymphocyte apoptosis, although the mechanism by which they…”
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Myeloid-derived Suppressor Cells Adhere to Physiologic STAT3- vs STAT5-dependent Hematopoietic Programming, Establishing Diverse Tumor-Mediated Mechanisms of Immunologic Escape by Cohen, Peter A., Ko, Jennifer S., Storkus, Walter J., Spencer, Christopher D., Bradley, Judy M., Gorman, Jessica E., McCurry, Dustin B., Zorro-Manrique, Soroya, Dominguez, Anna Lucia, Pathangey, Latha B., Rayman, Patricia A., Rini, Brian I., Gendler, Sandra J., Finke, James H.

“…The receptor tyrosine kinase inhibitor, sunitinib, is astonishingly effective in its capacity to reduce MDSCs in peripheral tissues such as blood (human) and…”
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Differential gene expression in G-MDSC and neutrophils from renal cell carcinoma patients by Ko, Jennifer, Rayman, Patricia A, Yang, Yu, Gopalan, Banu, Finke, James

“…Myeloid-derived suppressor cells (MDSC), including undifferentiated, monocytic, and granulocytic subsets, are known to play a role in tumor progression via…”
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IL-12 stimuli during ex vivo expansion not only prevents the upregulation of PD1 on tumor infiltrating adoptively transferred T cells but also on endogenous TILs which results in effective tumor regression by Diaz-Montero, C Marcela, Yang, Yu, Rayman, Patricia A, Montero, Alberto, Tannenbaum, Charlie, Finke, James

“…The blockade of negative immune regulators such as CTLA-4 and PD1 continues to show encouraging results in patients with solid malignancies. The efficacy of…”
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Effect of Renal Cell Carcinomas on the Development of Type 1 T-Cell Responses by RAYMAN, Patricia, WESA, Amy K, FINKE, James, RICHMOND, Amy L, DAS, Tanya, BISWAS, Kaushik, RAVAL, Gira, STORKUS, Walter J, TANNENBAUM, Charles, NOVICK, Andrew, BUKOWSKI, Ronald

“…Purpose: We reported that in renal cell carcinoma patients with active disease, T-cell reactions to the tumor-associated antigens MAGE-6 and EphA2 are highly…”
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