Search Results - "RAYMAKERS, Reinier"

Acquired mutations in TET2 are common in myelodysplastic syndromes by Jansen, Joop H, Langemeijer, Saskia M C, Kuiper, Roland P, Berends, Marieke, Knops, Ruth, Aslanyan, Mariam G, Massop, Marion, Stevens-Linders, Ellen, van Hoogen, Patricia, van Kessel, Ad Geurts, Raymakers, Reinier A P, Kamping, Eveline J, Verhoef, Gregor E, Verburgh, Estelle, Hagemeijer, Anne, Vandenberghe, Peter, de Witte, Theo, van der Reijden, Bert A

“…Myelodysplastic syndromes (MDS) represent a heterogeneous group of neoplastic hematopoietic disorders. Several recurrent chromosomal aberrations have been…”
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From MGUS to Multiple Myeloma, a Paradigm for Clonal Evolution of Premalignant Cells by van Nieuwenhuijzen, Niels, Spaan, Ingrid, Raymakers, Reinier, Peperzak, Victor

“…Multiple myeloma (MM) is a treatable, but incurable, malignancy of plasma cells (PC) in the bone marrow (BM). It represents the final stage in a continuum of…”
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CCN2/CTGF expression does not correlate with fibrosis in myeloproliferative neoplasms, consistent with noncanonical TGF-β signaling driving myelofibrosis by Leguit, Roos J., Broekhuizen, Roel, de Witte, Moniek, Raymakers, Reinier A. P., Goldschmeding, Roel

“…The classical BCR::ABL1 -negative myeloproliferative neoplasms (MPN) form a group of bone marrow (BM) diseases with the potential to progress to acute myeloid…”
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Wnt signaling in multiple myeloma: a central player in disease with therapeutic potential by Spaan, Ingrid, Raymakers, Reinier A, van de Stolpe, Anja, Peperzak, Victor

“…Multiple myeloma is the second most frequent hematological malignancy in the western world and remains incurable, predominantly due to acquired drug resistance…”
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Practice guidelines for the diagnosis and management of microcytic anemias due to genetic disorders of iron metabolism or heme synthesis by Donker, Albertine E., Raymakers, ReinierA.P., Vlasveld, L. Thom, van Barneveld, Teus, Terink, Rieneke, Dors, Natasja, Brons, Paul P.T., Knoers, Nine V.A.M., Swinkels, Dorine W.

“…During recent years, our understanding of the pathogenesis of inherited microcytic anemias has gained from the identification of several genes and proteins…”
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Anemia in Hodgkin's Lymphoma: The Role of Interleukin-6 and Hepcidin by HOHAUS, Stefan, MASSINI, Giuseppina, VOSO, Maria Teresa, LEONE, Giuseppe, GIACHELIA, Manuela, VANNATA, Barbara, BOZZOLI, Valentina, CUCCARO, Annarosa, D'ALO, Francesco, LAROCCA, Luigi Maria, RAYMAKERS, Reinier A. P, SWINKELS, Dorine W

“…Cytokines play a pivotal role in Hodgkin's lymphoma (HL). Because interleukin-6 (IL-6) induces expression of hepcidin, one of the principal regulators of iron…”
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CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis by Leguit, Roos J., Raymakers, Reinier A. P., Hebeda, Konnie M., Goldschmeding, Roel

“…CCN2, formerly termed Connective Tissue Growth Factor, is a protein belonging to the Cellular Communication Network (CCN)-family of secreted extracellular…”
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The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity by van Spriel, Annemiek B, Sofi, Mariam, Gartlan, Kate H, van der Schaaf, Alie, Verschueren, Ineke, Torensma, Ruurd, Raymakers, Reinier A P, Loveland, Bruce E, Netea, Mihai G, Adema, Gosse J, Wright, Mark D, Figdor, Carl G

“…Immunoglobulin A (IgA) secretion by plasma cells in the immune system is critical for protecting the host from environmental and microbial infections. However,…”
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Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a multicentre, retrospective, pharmacodynamic cohort analysis by Admiraal, Rick, MD, Nierkens, Stefan, PhD, de Witte, Moniek A, MD, Petersen, Eefke J, MD, Fleurke, Ger-jan, MD, Verrest, Luka, MSc, Belitser, Svetlana V, MSc, Bredius, Robbert G M, MD, Raymakers, Reinier A P, MD, Knibbe, Catherijne A J, Prof, Minnema, Monique C, MD, van Kesteren, Charlotte, PhD, Kuball, Jurgen, Prof, Boelens, Jaap J, Dr

“…Summary Background Anti-thymocyte globulin (ATG) is used to prevent graft-versus-host disease (GvHD) after allogeneic haemopoietic cell transplantation (HCT)…”
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Bortezomib Induction and Maintenance Treatment in Patients With Newly Diagnosed Multiple Myeloma: Results of the Randomized Phase III HOVON-65/ GMMG-HD4 Trial by SONNEVELD, Pieter, SCHMIDT-WOLF, Ingo G. H, WEISEL, Katja C, WITTEBOL, Shulamiet, BOS, Gerard M. J, STEVENS-KROEF, Marian, SCHEID, Christof, PFREUNDSCHUH, Michael, HOSE, Dirk, JAUCH, Anna, DER VELDE, Helgi Van, RAYMAKERS, Reinier, DER HOLT, Bronno Van, SCHAAFSMA, Martijn R, KERSTEN, Marie-Jose, MARWIJK-KOOY, Marinus Van, DUEHRSEN, Ulrich, LINDEMANN, Walter, WIJERMANS, Pierre W, LOKHORST, Henk M, GOLDSCHMIDT, Hartmut M, EL JARARI, Laila, BERTSCH, Uta, SALWENDER, Hans, ZWEEGMAN, Sonja, VELLENGA, Edo, BROYL, Annemiek, BLAU, Igor W

“…We investigated whether bortezomib during induction and maintenance improves survival in newly diagnosed multiple myeloma (MM). In all, 827 eligible patients…”
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Functional differences between mesenchymal stem cell populations are reflected by their transcriptome by Jansen, Bastiaan J H, Gilissen, Christian, Roelofs, Helene, Schaap-Oziemlak, Aneta, Veltman, Joris A, Raymakers, Reinier A P, Jansen, Joop H, Kögler, Gesine, Figdor, Carl G, Torensma, Ruurd, Adema, Gosse J

“…Stem cells are widely studied to enable their use in tissue repair. However, differences in function and differentiation potential exist between distinct stem…”
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Safety and efficacy of pomalidomide plus low-dose dexamethasone in STRATUS (MM-010): a phase 3b study in refractory multiple myeloma by Dimopoulos, Meletios A., Palumbo, Antonio, Corradini, Paolo, Cavo, Michele, Delforge, Michel, Di Raimondo, Francesco, Weisel, Katja C., Oriol, Albert, Hansson, Markus, Vacca, Angelo, Blanchard, María Jesús, Goldschmidt, Hartmut, Doyen, Chantal, Kaiser, Martin, Petrini, Mario, Anttila, Pekka, Cafro, Anna Maria, Raymakers, Reinier, San-Miguel, Jesus, de Arriba, Felipe, Knop, Stefan, Röllig, Christoph, Ocio, Enrique M., Morgan, Gareth, Miller, Neil, Simcock, Mathew, Peluso, Teresa, Herring, Jennifer, Sternas, Lars, Zaki, Mohamed H., Moreau, Philippe

“…Patients with relapsed and/or refractory multiple myeloma (RRMM) have poor prognosis. The STRATUS study assessed safety and efficacy of pomalidomide plus…”
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Quantitative characterization of immune cells by measuring cellular signal transduction pathway activity by Bouwman, Wilbert, Verhaegh, Wim, van Doorn, Arie, Raymakers, Reinier, van der Poll, Tom, van de Stolpe, Anja

“…For many diseases, including cancer, infections, and auto-immune diseases, the immune response is a major determinant of disease progression, response to…”
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Relative survival reaches a plateau in hairy cell leukemia: a population-based analysis in The Netherlands by Dinmohamed, Avinash G., Posthuma, Eduardus F.M., Visser, Otto, Kater, Arnon P., Raymakers, Reinier A.P., Doorduijn, Jeanette K.

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Multiple Myeloma Relapse Is Associated with Increased NFκB Pathway Activity and Upregulation of the Pro-Survival BCL-2 Protein BFL-1 by Spaan, Ingrid, van de Stolpe, Anja, Raymakers, Reinier A., Peperzak, Victor

“…Multiple myeloma (MM) is a hematological malignancy that is still considered incurable due to the development of therapy resistance and subsequent relapse of…”
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Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a retrospective, pharmacodynamic cohort analysis by Admiraal, Rick, Nierkens, Stefan, de Witte, Moniek A, Petersen, Eefke J, Fleurke, Ger-jan, Verrest, Luka, Belitser, Svetlana V, Bredius, Robbert G M, Raymakers, Reinier A P, Knibbe, Catherijne A J, Minnema, Monique C, van Kesteren, Charlotte, Kuball, Jurgen, Boelens, Jaap J

“…Anti-thymocyte globulin (ATG) is used to prevent graft-versus-host disease (GvHD) after allogeneic haemopoietic cell transplantation (HCT). However, ATG can…”
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EBV-related lymphoma after long-term daratumumab treatment: a case report by Verpoorte-Botden, Ilse P. G., Minnema, Monique C., Raymakers, Reinier A. P.

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A Critical Role for Prostaglandin E2 in Podosome Dissolution and Induction of High-Speed Migration during Dendritic Cell Maturation by van Helden, Suzanne F. G, Krooshoop, Danielle J. E. B, Broers, Karin C. M, Raymakers, Reinier A. P, Figdor, Carl G, van Leeuwen, Frank N

“…Dendritic cells (DCs) are professional APCs of the immune system that play a key role in regulating T cell-based immunity. The capacity of DCs to activate T…”
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Feasibility and efficacy of addition of individualized-dose lenalidomide to chlorambucil and rituximab as first-line treatment in elderly and FCR-unfit patients with advanced chronic lymphocytic leukemia by Kater, Arnon P, van Oers, Marinus H J, van Norden, Yvette, van der Straten, Lina, Driessen, Julia, Posthuma, Ward F M, Schipperus, Martin, Chamuleau, Martine E D, Nijland, Marcel, Doorduijn, Jeanette K, Van Gelder, Michel, Hoogendoorn, Mels, De Croon, Francien, Wittebol, Shulamiet, Kerst, J Martijn, Marijt, Erik W A, Raymakers, Reinier A P, Schaafsma, Martijn R, Dobber, Johan A, Kersting, Sabina, Levin, Mark-David

“…Lenalidomide has been proven to be effective but with a distinct and difficult to manage toxicity profile in the context of chronic lymphocytic leukemia,…”
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Comparison of modern and conventional imaging techniques in establishing multiple myeloma‐related bone disease: a systematic review by Regelink, Josien C., Minnema, Monique C., Terpos, Evangelos, Kamphuis, Marjolein H., Raijmakers, Pieter G., Pieters – van den Bos, Indra C., Heggelman, Ben G. F., Nievelstein, Rutger‐Jan, Otten, Rene. H. J., Lammeren – Venema, Danielle, Zijlstra, Josee M., Arens, Anne I. J., Rooy, Jacky W., Hoekstra, Otto S., Raymakers, Reinier, Sonneveld, Pieter, Ostelo, Raymond W., Zweegman, Sonja

“…Summary This systematic review of studies compared magnetic resonance imaging (MRI), 18F‐fluorodeoxyglucose positron emission tomography (FDG‐PET), FDG‐PET…”
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