Search Results - "RAVETCH, J. V"

Intravenous immunoglobulins - understanding properties and mechanisms by Durandy, A, Kaveri, S.V, Kuijpers, T.W, Basta, M, Miescher, S, Ravetch, J.V, Rieben, R

“…High-dose intravenous immunoglobulin (IVIg) preparations are used currently for the treatment of autoimmune or inflammatory diseases. Despite numerous studies…”
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Anti-Inflammatory Activity of IVIG Mediated through the Inhibitory Fc Receptor by Samuelsson, Astrid, Towers, Terri L., Ravetch, Jeffrey V.

“…The molecular basis for the anti-inflammatory property of intravenous gamma globulin (IVIG) was investigated in a murine model of immune thrombocytopenia…”
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IGG FC RECEPTORS by Ravetch, Jeffrey V, Bolland, Silvia

“…Since the description of the first mouse knockout for an IgG Fc receptor seven years ago, considerable progress has been made in defining the in vivo functions…”
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Immune Inhibitory Receptors by Ravetch, Jeffrey V., Lanier, Lewis L.

“…With the detailed description and analysis of several inhibitory receptor systems on lymphoid and myeloid cells, a central paradigm has emerged in which the…”
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Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo by Hawiger, D, Inaba, K, Dorsett, Y, Guo, M, Mahnke, K, Rivera, M, Ravetch, J V, Steinman, R M, Nussenzweig, M C

“…Dendritic cells (DCs) have the capacity to initiate immune responses, but it has been postulated that they may also be involved in inducing peripheral…”
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Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB by ONO, M, BOLLAND, S, TEMPST, P, RAVETCH, J. V

“…Immune complexes are potent activators of inflammatory cells, triggering effector responses through the crosslinking of Fc receptors (FcRs) such as…”
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Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis by Clynes, Raphael, Dumitru, Calin, Ravetch, Jeffrey V.

“…The generation of autoantibody and subsequent tissue deposition of immune complexes (IC) is thought to trigger the pathogenic consequences of systemic…”
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Augmented humoral and anaphylactic responses in FcγRII-deficient mice by Takai, Toshiyuki, Ono, Masao, Hikida, Masaki, Ohmori, Hitoshi, Ravetch, Jeffrey V

“…Despite its widespread distribution on both lymphoid and myeloid cells, the biological role of the low-affinity immunoglobulin-G receptor, Fc gamma RII, is not…”
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Fc Receptors by Ravetch, J V, Kinet, J P

“…Recent advances in the structural analysis of the genes and proteins for immunoglobulin Fc domain receptors have provided a molecular characterization of this…”
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Fc Receptors Initiate the Arthus Reaction: Redefining the Inflammatory Cascade by Sylvestre, Diana L., Ravetch, Jeffrey V.

“…Antibody-antigen complexes initiate the inflammatory response and are central to the pathogenesis of tissue injury. The classical model for this…”
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Alternative membrane forms of FcγRIII(CD16) on human natural killer cells and neutrophils: cell type-specific expression of two genes that differ in single nucleotide substitutions by RAVETCH, J. V, PERUSSIA, B

“…A low affinity receptor for IgG immune complexes, Fc gamma RIII(CD16), is expressed on human NK cells as an integral membrane glycoprotein anchored through a…”
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Fc receptors: rubor redux by Ravetch, J V

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A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling by Muta, Tatsushi, Kurosaki, Tomohiro, Misulovin, Ziva, Sanchez, Mercedes, Nussenzweig, Michel C, Ravetch, Jeffrey V

“…The Fc receptor on B lymphocytes, Fc gamma RIIB (beta 1 isoform), helps to modulate B-cell activation triggered by the surface immunoglobulin complex…”
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Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritis by Suzuki, Yusuke, Shirato, Isao, Okumura, Ko, Ravetch, Jeffrey V., Takai, Toshiyuki, Tomino, Yasuhiko, Ra, Chisei

“…Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritis. The contribution of antibody and/or immune-complex…”
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A new mouse expressing human Fcγ receptors to better predict therapeutic efficacy of human anti-cancer antibodies by Casey, E, Bournazos, S, Mo, G, Mondello, P, Tan, K S, Ravetch, J V, Scheinberg, D A

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Interferon γ-Induced Transcription of the High-Affinity Fc Receptor for IgG Requires Assembly of a Complex That Includes the 91-kDa Subunit of Transcription Factor ISGF3 by Pearse, Roger N., Feinman, Rena, Shuai, Ke, Darnell, James E., Ravetch, Jeffrey V.

“…A 39-nt DNA sequence, the interferon γ (IFN-γ) response region (GRR), is necessary for the IFN-γ-induced transcription of the high-affinity Fc receptor for IgG…”
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Structure and expression of human IgG FcRII(CD32): functional heterogeneity is encoded by the alternatively spliced products of multiple genes by BROOKS, D. G, QIU, W. Q, LUSTER, A. D, RAVETCH, J. V

“…The structural heterogeneity of the human low affinity receptor for IgG, FcRII(CD32), has been elucidated through the isolation, characterization, and…”
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Signal transduction by Fcγ-RIII (CD16) is mediated through the γ chain by WIRTHMUELLER, U, KUROSAKI, T, MURAKAMI, M. S, RAVETCH, J. V

“…To determine the functional role of the two isoforms of Fc gamma RIII (CD16) (IIIA, IIIB), the signal transduction capabilities of wild-type and mutant forms…”
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Characterization of the Promoter of the Human Gene Encoding the High- Affinity IgG Receptor: Transcriptional Induction by γ-Interferon is Mediated Through Common DNA Response Elements by PEARSE, R. N, FEINMAN, R, RAVETCH, J. V

“…Expression of the high-affinity receptor for IgG (FcγRI) is restricted to cells of myeloid lineage and is induced by γ-interferon (IFN-γ) but not by IFN-αβ…”
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Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis by Bolland, Silvia, Ravetch, Jeffrey V

“…By virtue of its ability to couple the BCR to an inhibitory pathway, FcγRIIB can potentially determine the fate of B cells upon IgG immune complex engagement…”
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