Search Results - "RAVEH, LILY"

Caramiphen edisylate: An optimal antidote against organophosphate poisoning by Raveh, Lily, Eisenkraft, Arik, Weissman, Ben Avi

“…Abstract Potent cholinesterase inhibitors such as sarin, induce an array of harmful effects including hypersecretion, convulsions and ultimately death…”
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Novel bifunctional hybrid small molecule scavengers for mitigating nerve agents toxicity by Amitai, Gabriel, Gez, Rellie, Raveh, Lily, Bar-Ner, Nira, Grauer, Ettie, Chapman, Shira

“…The antidotal treatment of organophosphates (OP) nerve agents (NA) poisoning is based on anticholinergics (e.g. atropine) combined with oxime reactivators…”
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Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds by Cohen, Ofer, Kronman, Chanoch, Raveh, Lily, Mazor, Ohad, Ordentlich, Arie, Shafferman, Avigdor

“…Comparative protection studies in mice demonstrate that on a molar basis, recombinant human acetylcholinesterase (rHuAChE) confers higher levels of protection…”
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Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase by Mazor, Ohad, Cohen, Ofer, Kronman, Chanoch, Raveh, Lily, Stein, Dana, Ordentlich, Arie, Shafferman, Avigdor

“…The high reactivity of cholinesterases (ChEs) toward organophosphorus (OP) compounds has led to propose recombinant ChEs as bioscavengers of nerve agents. The…”
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Peripheral benzodiazepine receptors: on mice and human brain imaging by Weissman, Ben Avi, Raveh, Lily

“…There are numerous methods designed to monitor brain neuropathologies resulting from a wide arsenal of insults. Regardless of the cause of neuronal death,…”
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Efficacy of antidotal treatment against sarin poisoning: The superiority of benactyzine and caramiphen by Raveh, Lily, Rabinovitz, Ishai, Gilat, Eran, Egoz, Inbal, Kapon, Joseph, Stavitsky, Ziv, Avi Weissman, Ben, Brandeis, Rachel

“…Sarin, a potent cholinesterase inhibitor, induces an array of toxic effects including convulsions and behavioral impairments. We report here on the protection…”
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Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning by LUNDY, Paul M, RAVEH, Lily, AMITAI, Gabriel

“…The traditional therapeutic treatment of organophosphate cholinesterase inhibitor (nerve agents) poisoning consists of co-treatment with an antimuscarinic…”
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Extrapolating from animal studies to the efficacy in humans of a pretreatment combination against organophosphate poisoning by LEVY, Aharon, COHEN, Giora, GILAT, Eran, KAPON, Joseph, DACHIR, Shlomit, ABRAHAM, Shlomo, HERSKOVITZ, Miriam, TEITELBAUM, Zvi, RAVEH, Lily

“…The extrapolation from animal data to therapeutic effects in humans, a basic pharmacological issue, is especially critical in studies aimed to estimate the…”
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Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases by Saxena, A, Ashani, Y, Raveh, L, Stevenson, D, Patel, T, Doctor, B P

“…To understand the role of glycosylation in the circulation of cholinesterases, we compared the mean residence time of five tissue-derived and two recombinant…”
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Multifunctional drugs as novel antidotes for organophosphates’ poisoning by Weissman, Ben Avi, Raveh, Lily

“…Highlights ► Exposures to organophosphates produce complex pathological circumstances ► Conjugating drugs active against OP toxicity may lead to better…”
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Sarin-induced brain damage in rats is attenuated by delayed administration of midazolam by Chapman, Shira, Yaakov, Guy, Egoz, Inbal, Rabinovitz, Ishai, Raveh, Lily, Kadar, Tamar, Gilat, Eran, Grauer, Ettie

“…•Time and dose effect of midazolam was studied in rats following sarin intoxication.•Immediate treatment with TA (TMB4+atropine) displayed prolonged seizures…”
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Therapy against organophosphate poisoning: The importance of anticholinergic drugs with antiglutamatergic properties by Weissman, Ben Avi, Raveh, Lily

“…Potent cholinesterase inhibitors (e.g., soman, sarin), induce a wide range of deleterious effects including convulsions, behavioral impairments and ultimately,…”
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Is rivastigmine safe as pretreatment against nerve agents poisoning? A pharmacological, physiological and cognitive assessment in healthy young adult volunteers by Lavon, Ophir, Eisenkraft, Arik, Blanca, Merav, Raveh, Lily, Ramaty, Erez, Krivoy, Amir, Atsmon, Jacob, Grauer, Ettie, Brandeis, Rachel

“…•Rivastigmine induces mild adverse reactions with high inter-personal variability.•Rivastigmine impairs 2 cognitive functions (perceptual speed and dynamic…”
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Magnesium sulfate treatment against sarin poisoning: dissociation between overt convulsions and recorded cortical seizure activity by Katalan, Shahaf, Lazar, Shlomi, Brandeis, Rachel, Rabinovitz, Ishai, Egoz, Inbal, Grauer, Ettie, Bloch-Shilderman, Eugenia, Raveh, Lily

“…Sarin, a potent organophosphate cholinesterase inhibitor, induces an array of toxic effects including convulsions. Many antidotal treatments contain…”
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Next generation OP-bioscavengers: A circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics by Kronman, Chanoch, Cohen, Ofer, Mazor, Ohad, Ordentlich, Arie, Raveh, Lily, Velan, Baruch, Shafferman, Avigdor

“…We have shown previously that conjugation of polyethylene glycol (PEG) chains to recombinant human acetylcholinesterase (rHuAChE) results in the extension of…”
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Single whole-body exposure to sarin vapor in rats: Long-term neuronal and behavioral deficits by Grauer, Ettie, Chapman, Shira, Rabinovitz, Ishai, Raveh, Lily, Weissman, Ben-Avi, Kadar, Tamar, Allon, Nahum

“…Freely moving rats were exposed to sarin vapor (34.2 ± 0.8 μg/l) for 10 min. Mortality at 24 h was 35% and toxic sings in the surviving rats ranged from sever…”
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Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication by Kronman, Chanoch, Cohen, Ofer, Raveh, Lily, Mazor, Ohad, Ordentlich, Arie, Shafferman, Avigdor

“…Abstract Extensive pharmacokinetic studies in both mice and rhesus macaques, with biochemically well defined forms of native and recombinant AChEs from bovine,…”
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Anticholinergic and Antiglutamatergic Agents Protect against Soman-Induced Brain Damage and Cognitive Dysfunction by Raveh, Lily, Brandeis, Rachel, Gilat, Eran, Cohen, Giora, Alkalay, David, Rabinovitz, Ishai, Sonego, Hagar, Weissman, Ben Avi

“…Soman, a powerful inhibitor of acetylcholinesterase, causes an array of toxic effects in the central nervous system including convulsions, learning and memory…”
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The Stoichiometry of Protection against Soman and VX Toxicity in Monkeys Pretreated with Human Butyrylcholinesterase by Raveh, Lily, Grauer, Ettie, Grunwald, Jacob, Cohen, E., Ashani, Yacov

“…Bioscavengers of organophophates (OP) have been examined as potential substitutes for the currently approved drug treatment against OP toxicity. The present…”
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Subchronic exposure to low-doses of the nerve agent VX: Physiological, behavioral, histopathological and neurochemical studies by Bloch-Shilderman, Eugenia, Rabinovitz, Ishai, Egoz, Inbal, Raveh, Lily, Allon, Nahum, Grauer, Ettie, Gilat, Eran, Weissman, Ben Avi

“…The highly toxic organophosphorous compound VX [ O-ethyl- S-(isoporopylaminoethyl) methyl phosphonothiolate] undergoes an incomplete decontamination by…”
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