Search Results - "RATTO, GIAN MICHELE"

Dendritic Spine Instability in a Mouse Model of CDKL5 Disorder Is Rescued by Insulin-like Growth Factor 1 by Della Sala, Grazia, Putignano, Elena, Chelini, Gabriele, Melani, Riccardo, Calcagno, Eleonora, Michele Ratto, Gian, Amendola, Elena, Gross, Cornelius T, Giustetto, Maurizio, Pizzorusso, Tommaso

“…Abstract Background CDKL5 (cyclin-dependent kinase-like 5) is mutated in many severe neurodevelopmental disorders, including atypical Rett syndrome. CDKL5 was…”
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Daily rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability by Pracucci, Enrico, Graham, Robert T., Alberio, Laura, Nardi, Gabriele, Cozzolino, Olga, Pillai, Vinoshene, Pasquini, Giacomo, Saieva, Luciano, Walsh, Darren, Landi, Silvia, Zhang, Jinwei, Trevelyan, Andrew J., Ratto, Gian-Michele

“…Cortical activity patterns are strongly modulated by fast synaptic inhibition mediated through ionotropic, chloride-conducting receptors. Consequently,…”
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Control of circadian rhythm on cortical excitability and synaptic plasticity by Lodovichi, Claudia, Ratto, Gian Michele

“…Living organisms navigate through a cyclic world: activity, feeding, social interactions are all organized along the periodic succession of night and day. At…”
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Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo by Sato, Sebastian Sulis, Artoni, Pietro, Landi, Silvia, Cozzolino, Olga, Parra, Riccardo, Pracucci, Enrico, Trovato, Francesco, Szczurkowska, Joanna, Luin, Stefano, Arosio, Daniele, Beltram, Fabio, Cancedda, Laura, Kaila, Kai, Ratto, Gian Michele

“…Intracellular chloride ([Cl⁻]i) and pH(pHi) are fundamental regulators of neuronal excitability. They exert wide-ranging effects on synaptic signaling and…”
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Twenty years of fluorescence imaging of intracellular chloride by Arosio, Daniele, Ratto, Gian Michele

“…Chloride homeostasis has a pivotal role in controlling neuronal excitability in the adult brain and during development. The intracellular concentration of…”
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Transient Cognitive Impairment in Epilepsy by Landi, Silvia, Petrucco, Luigi, Sicca, Federico, Ratto, Gian Michele

“…Impairments of the dialog between excitation and inhibition (E/I) is commonly associated to neuropsychiatric disorders like autism, bipolar disorders and…”
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Altered Cl⁻ homeostasis hinders forebrain GABAergic interneuron migration in a mouse model of intellectual disability by Maset, Andrea, Galla, Luisa, Francia, Simona, Cozzolino, Olga, Capasso, Paola, Goisis, Rosa Chiara, Losi, Gabriele, Lombardo, Angelo, Ratto, Gian Michele, Lodovichi, Claudia

“…Impairments of inhibitory circuits are at the basis of most, if not all, cognitive deficits. The impact of OPHN1, a gene associate with intellectual disability…”
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An excitatory loop with astrocytes contributes to drive neurons to seizure threshold by Gómez-Gonzalo, Marta, Losi, Gabriele, Chiavegato, Angela, Zonta, Micaela, Cammarota, Mario, Brondi, Marco, Vetri, Francesco, Uva, Laura, Pozzan, Tullio, de Curtis, Marco, Ratto, Gian Michele, Carmignoto, Giorgio

“…Seizures in focal epilepsies are sustained by a highly synchronous neuronal discharge that arises at restricted brain sites and subsequently spreads to large…”
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High-performance and site-directed in utero electroporation by a triple-electrode probe by dal Maschio, Marco, Ghezzi, Diego, Bony, Guillaume, Alabastri, Alessandro, Deidda, Gabriele, Brondi, Marco, Sato, Sebastian Sulis, Zaccaria, Remo Proietti, Di Fabrizio, Enzo, Ratto, Gian Michele, Cancedda, Laura

“…In utero electroporation is a powerful tool to transfect and manipulate neural-precursor cells of the rodent parietal cortex and their progeny in vivo …”
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Trehalose Treatment in Zebrafish Model of Lafora Disease by Della Vecchia, Stefania, Ogi, Asahi, Licitra, Rosario, Abramo, Francesca, Nardi, Gabriele, Mero, Serena, Landi, Silvia, Battini, Roberta, Sicca, Federico, Ratto, Gian Michele, Santorelli, Filippo Maria, Marchese, Maria

“…Mutations in the EPM2A gene encoding laforin cause Lafora disease (LD), a progressive myoclonic epilepsy characterized by drug-resistant seizures and…”
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Understanding Spreading Depression from Headache to Sudden Unexpected Death by Cozzolino, Olga, Marchese, Maria, Trovato, Francesco, Pracucci, Enrico, Ratto, Gian Michele, Buzzi, Maria Gabriella, Sicca, Federico, Santorelli, Filippo M

“…Spreading depression (SD) is a neurophysiological phenomenon characterized by abrupt changes in intracellular ion gradients and sustained depolarization of…”
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Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model by Marchese, Maria, Bernardi, Sara, Ogi, Asahi, Licitra, Rosario, Silvi, Giada, Mero, Serena, Galatolo, Daniele, Gammaldi, Nicola, Doccini, Stefano, Ratto, Gian Michele, Rapposelli, Simona, Neuhauss, Stephan C.F., Zang, Jingjing, Rocchiccioli, Silvia, Michelucci, Elena, Ceccherini, Elisa, Santorelli, Filippo M.

“…CLN8 is an endoplasmic reticulum cargo receptor and a regulator of lysosome biogenesis whose loss of function leads to neuronal ceroid lipofuscinosis. CLN8 has…”
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Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons by Faini, Giulia, Aguirre, Andrea, Landi, Silvia, Lamers, Didi, Pizzorusso, Tommaso, Ratto, Gian Michele, Deleuze, Charlotte, Bacci, Alberto

“…In the neocortex, critical periods (CPs) of plasticity are closed following the accumulation of perineuronal nets (PNNs) around parvalbumin (PV)-positive…”
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The short-time structural plasticity of dendritic spines is altered in a model of Rett syndrome by Landi, Silvia, Putignano, Elena, Boggio, Elena Maria, Giustetto, Maurizio, Pizzorusso, Tommaso, Ratto, Gian Michele

“…The maturation of excitatory transmission comes about through a developmental period in which dendritic spines are highly motile and their number, form and…”
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Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter by Trovato, Francesco, Parra, Riccardo, Pracucci, Enrico, Landi, Silvia, Cozzolino, Olga, Nardi, Gabriele, Cruciani, Federica, Pillai, Vinoshene, Mosti, Laura, Cwetsch, Andrzej W., Cancedda, Laura, Gritti, Laura, Sala, Carlo, Verpelli, Chiara, Maset, Andrea, Lodovichi, Claudia, Ratto, Gian Michele

“…Genetic mosaicism, a condition in which an organ includes cells with different genotypes, is frequently present in monogenic diseases of the central nervous…”
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Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling by Pagano, Jessica, Landi, Silvia, Stefanoni, Alessia, Nardi, Gabriele, Albanesi, Marica, Bauer, Helen F, Pracucci, Enrico, Schön, Michael, Ratto, Gian Michele, Boeckers, Tobias M, Sala, Carlo, Verpelli, Chiara

“…Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, and autistic-like behaviors and…”
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Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2 by Indrigo, Marzia, Morella, Ilaria, Orellana, Daniel, d'Isa, Raffaele, Papale, Alessandro, Parra, Riccardo, Gurgone, Antonia, Lecca, Daniela, Cavaccini, Anna, Tigaret, Cezar M, Cagnotto, Alfredo, Jones, Kimberley, Brooks, Simon, Ratto, Gian Michele, Allen, Nicholas D, Lelos, Mariah J, Middei, Silvia, Giustetto, Maurizio, Carta, Anna R, Tonini, Raffaella, Salmona, Mario, Hall, Jeremy, Thomas, Kerrie, Brambilla, Riccardo, Fasano, Stefania

“…Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic…”
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Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex by Cadeddu, Roberto, Mosher, Laura J., Nordkild, Peter, Gaikwad, Nilesh, Ratto, Gian Michele, Scheggi, Simona, Bortolato, Marco

“…Ample evidence indicates that environmental stress impairs information processing, yet the underlying mechanisms remain partially elusive. We showed that, in…”
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Molecular basis of plasticity in the visual cortex by Berardi, Nicoletta, Pizzorusso, Tommaso, Ratto, Gian Michele, Maffei, Lamberto

“…Sensory experience is known to shape the maturation of cortical circuits during development. A paradigmatic example is the effect of monocular deprivation on…”
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Evolution of Epileptiform Activity in Zebrafish by Statistical-Based Integration of Electrophysiology and 2-Photon Ca2+ Imaging by Cozzolino, Olga, Sicca, Federico, Paoli, Emanuele, Trovato, Francesco, Santorelli, Filippo M., Ratto, Gian Michele, Marchese, Maria

“…The study of sources and spatiotemporal evolution of ictal bursts is critical for the mechanistic understanding of epilepsy and for the validation of…”
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