Search Results - "RATNER, NANCY"

iGEAK: an interactive gene expression analysis kit for seamless workflow using the R/shiny platform by Choi, Kwangmin, Ratner, Nancy

“…The use of microarrays and RNA-seq technologies is ubiquitous for transcriptome analyses in modern biology. With proper analysis tools, the differential gene…”
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Activity of Selumetinib in Neurofibromatosis Type 1–Related Plexiform Neurofibromas by Dombi, Eva, Baldwin, Andrea, Marcus, Leigh J, Fisher, Michael J, Weiss, Brian, Kim, AeRang, Whitcomb, Patricia, Martin, Staci, Aschbacher-Smith, Lindsey E, Rizvi, Tilat A, Wu, Jianqiang, Ershler, Rachel, Wolters, Pamela, Therrien, Janet, Glod, John, Belasco, Jean B, Schorry, Elizabeth, Brofferio, Alessandra, Starosta, Amy J, Gillespie, Andrea, Doyle, Austin L, Ratner, Nancy, Widemann, Brigitte C

“…Plexiform neurofibroma is a complication of the NF1 mutation in neurofibromatosis that results in overactivity of the RAS pathway. Selumetinib, a…”
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Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis by Heinrich, Anna, Potter, Sarah J., Guo, Li, Ratner, Nancy, DeFalco, Tony

“…Sertoli cells are supporting cells of the testicular seminiferous tubules, which provide a nurturing environment for spermatogenesis. Adult Sertoli cells are…”
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MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors by Jessen, Walter J, Miller, Shyra J, Jousma, Edwin, Wu, Jianqiang, Rizvi, Tilat A, Brundage, Meghan E, Eaves, David, Widemann, Brigitte, Kim, Mi-Ok, Dombi, Eva, Sabo, Jessica, Hardiman Dudley, Atira, Niwa-Kawakita, Michiko, Page, Grier P, Giovannini, Marco, Aronow, Bruce J, Cripe, Timothy P, Ratner, Nancy

“…Neurofibromatosis type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable peripheral nerve…”
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Merlin tumor suppressor function is regulated by PIP2-mediated dimerization by Hennigan, Robert F, Thomson, Craig S, Stachowski, Kye, Nassar, Nicolas, Ratner, Nancy

“…Neurofibromatosis Type 2 is an inherited disease characterized by Schwann cell tumors of cranial and peripheral nerves. The NF2 gene encodes Merlin, a member…”
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How does the Schwann cell lineage form tumors in NF1? by Carroll, Steven L., Ratner, Nancy

“…Neurofibromas are benign tumors of peripheral nerve that occur sporadically or in patients with the autosomal dominant tumor predisposition syndrome…”
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Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis by Wu, Lai Man Natalie, Deng, Yaqi, Wang, Jincheng, Zhao, Chuntao, Wang, Jiajia, Rao, Rohit, Xu, Lingli, Zhou, Wenhao, Choi, Kwangmin, Rizvi, Tilat A., Remke, Marc, Rubin, Joshua B., Johnson, Randy L., Carroll, Thomas J., Stemmer-Rachamimov, Anat O., Wu, Jianqiang, Zheng, Yi, Xin, Mei, Ratner, Nancy, Lu, Q. Richard

“…Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann cell (SC)-lineage-derived sarcomas. Molecular events driving SC-to-MPNST…”
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Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future by Reilly, Karlyne M, Kim, AeRang, Blakely, Jaishri, Ferner, Rosalie E, Gutmann, David H, Legius, Eric, Miettinen, Markku M, Randall, R Lor, Ratner, Nancy, Jumbé, N L, Bakker, Annette, Viskochil, David, Widemann, Brigitte C, Stewart, Douglas R

“…Malignant peripheral nerve sheath tumor (MPNST) is an aggressive soft tissue sarcoma for which the only effective therapy is surgery. In 2016, an international…”
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Rac1 controls Schwann cell myelination through cAMP and NF2/merlin by Guo, Li, Moon, Chandra, Niehaus, Karen, Zheng, Yi, Ratner, Nancy

“…During peripheral nervous system development, Schwann cells (SCs) surrounding single large axons differentiate into myelinating SCs. Previous studies implicate…”
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Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis by Rahrmann, Eric P, Watson, Adrienne L, Keng, Vincent W, Choi, Kwangmin, Moriarity, Branden S, Beckmann, Dominic A, Wolf, Natalie K, Sarver, Aaron, Collins, Margaret H, Moertel, Christopher L, Wallace, Margaret R, Gel, Bernat, Serra, Eduard, Ratner, Nancy, Largaespada, David A

“…Eric Rahrmann and colleagues performed a transposon-based somatic mutagenesis screen for genes involved in malignant peripheral nerve sheath tumors (MPNSTs)…”
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Neurofibromatosis type 1: modeling CNS dysfunction by Gutmann, David H, Parada, Luis F, Silva, Alcino J, Ratner, Nancy

“…Neurofibromatosis type 1 (NF1) is the most common monogenic disorder in which individuals manifest CNS abnormalities. Affected individuals develop glial…”
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P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis by Patritti Cram, Jennifer, Wu, Jianqiang, Coover, Robert A, Rizvi, Tilat A, Chaney, Katherine E, Ravindran, Ramya, Cancelas, Jose A, Spinner, Robert J, Ratner, Nancy

“…Neurofibromatosis type 1 (NF1) is characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) show deregulated RAS signaling. NF1 is also…”
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Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria by Plotkin, Scott R., Blakeley, Jaishri O., Evans, D. Gareth, Hanemann, C. Oliver, Hulsebos, Theo J.M., Hunter-Schaedle, Kim, Kalpana, Ganjam V., Korf, Bruce, Messiaen, Ludwine, Papi, Laura, Ratner, Nancy, Sherman, Larry S., Smith, Miriam J., Stemmer-Rachamimov, Anat O., Vitte, Jeremie, Giovannini, Marco

“…Schwannomatosis is the third major form of neurofibromatosis and is characterized by the development of multiple schwannomas in the absence of bilateral…”
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Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy by Haworth, Kellie B, Arnold, Michael A, Pierson, Christopher R, Choi, Kwangmin, Yeager, Nicholas D, Ratner, Nancy, Roberts, Ryan D, Finlay, Jonathan L, Cripe, Timothy P

“…Successful treatment of neurofibromatosis type 1 (NF1)-associated tumors poses a significant clinical challenge. While the primary underlying genetic defect…”
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The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin by Rice, Frank L, Houk, George, Wymer, James P, Gosline, Sara J C, Guinney, Justin, Wu, Jianqiang, Ratner, Nancy, Jankowski, Michael P, La Rosa, Salvo, Dockum, Marilyn, Storey, James R, Carroll, Steven L, Albrecht, Phillip J, Riccardi, Vincent M

“…In addition to large plexiform neurofibromas (pNF), NF1 patients are frequently disfigured by cutaneous neurofibromas (cNF) and are often afflicted with…”
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Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment by Kershner, Leah J, Choi, Kwangmin, Wu, Jianqiang, Zhang, Xiyuan, Perrino, Melissa, Salomonis, Nathan, Shern, Jack F, Ratner, Nancy

“…To define alterations early in tumor formation, we studied nerve tumors in neurofibromatosis 1 (NF1), a tumor predisposition syndrome. Affected individuals…”
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Plexiform and Dermal Neurofibromas and Pigmentation Are Caused by Nf1 Loss in Desert Hedgehog-Expressing Cells by Wu, Jianqiang, Williams, Jon P., Rizvi, Tilat A., Kordich, Jennifer J., Witte, David, Meijer, Dies, Stemmer-Rachamimov, Anat O., Cancelas, Jose A., Ratner, Nancy

“…Neurofibromatosis type 1 ( Nf1) mutation predisposes to benign peripheral nerve (glial) tumors called neurofibromas. The point(s) in development when Nf1 loss…”
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Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors by Paudel, Siddhi N, Hutzen, Brian J, Miller, Katherine E, Garfinkle, Elizabeth A R, Chen, Chun-Yu, Wang, Pin-Yi, Glaspell, Andrea M, Currier, Mark A, Ringwalt, Emily M, Boon, Louis, Mardis, Elaine R, Cairo, Mitchell S, Ratner, Nancy, Dodd, Rebecca D, Cassady, Kevin A, Cripe, Timothy P

“…Malignant peripheral nerve sheath tumors (MPNST) pose a significant therapeutic challenge due to high recurrence rates after surgical resection and a largely…”
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Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone by Isfort, Ilka, Elges, Sandra, Cyra, Magdalene, Berthold, Ruth, Renner, Marcus, Mechtersheimer, Gunhild, Åman, Pierre, Larsson, Olle, Ratner, Nancy, Hafner, Susanne, Simmet, Thomas, Schliemann, Christoph, Rossig, Claudia, Dirksen, Uta, Grünewald, Inga, Wardelmann, Eva, Huss, Sebastian, Hartmann, Wolfgang, Trautmann, Marcel

“…Tumors of soft tissue and bone represent a heterogeneous group of neoplasias characterized by a wide variety of genetic aberrations. Albeit knowledge on…”
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Defective transcription elongation in a subset of cancers confers immunotherapy resistance by Modur, Vishnu, Singh, Navneet, Mohanty, Vakul, Chung, Eunah, Muhammad, Belal, Choi, Kwangmin, Chen, Xiaoting, Chetal, Kashish, Ratner, Nancy, Salomonis, Nathan, Weirauch, Matthew T., Waltz, Susan, Huang, Gang, Privette-Vinnedge, Lisa, Park, Joo-Seop, Janssen, Edith M., Komurov, Kakajan

“…The nature and role of global transcriptional deregulations in cancers are not fully understood. We report that a large proportion of cancers have widespread…”
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