Search Results - "RATNAM, Kapila"

Current Development of Clinical Inhibitors of Poly(ADP-Ribose) Polymerase in Oncology by RATNAM, Kapila, LOW, Jennifer A

“…Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme that signals the presence of DNA damage by catalyzing the addition of ADP-ribose units to DNA, histones,…”
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Inhibitors of Pantothenate Kinase: Novel Antibiotics for Staphylococcal Infections by CHOUDHRY, Anthony E, MANDICHAK, Tracy L, RATNAM, Kapila, BROSKEY, John P, EGOLF, Richard W, KINSLAND, Cynthia, BEGLEY, Tadhg P, SEEFELD, Mark A, KU, Thomas W, BROWN, James R, ZALACAIN, Magdalena

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Spectroscopic and Kinetic Characterization of the Recombinant Cytochrome c Reductase Fragment of Nitrate Reductase by Ratnam, Kapila, Shiraishi, Naomasa, Campbell, Wilbur H., Hille, Russ

“…The recombinant NADH-cytochrome c reductase fragment of spinach NADH-nitrate reductase (EC 1.6.6.1), consisting of the contiguous heme-containing cytochrome b…”
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The Molybdenum Centers of Xanthine Oxidase and Xanthine Dehydrogenase by Ryan, Matthew G., Ratnam, Kapila, Hille, Russ

“…The UV-visible absorbance change associated with reduction of the molybdenum centers of xanthine oxidase and xanthine dehydrogenase has been determined using a…”
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Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1‒AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones by PENNING, Trevor M., BURCZYNSKI, Michael E., JEZ, Joseph M., HUNG, Chien-Fu, LIN, Hseuh-Kung, MA, Haiching, MOORE, Margaret, PALACKAL, Nisha, RATNAM, Kapila

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Spectroscopic and Kinetic Characterization of the Recombinant Wild-type and C242S Mutant of the Cytochrome b Reductase Fragment of Nitrate Reductase (∗) by Ratnam, Kapila, Shiraishi, Naomasa, Campbell, Wilbur H., Hille, Russ

“…Spectroscopic and kinetic studies comparing the behavior of the recombinant cytochrome b reductase fragment of corn leaf nitrate reductase and a mutant in…”
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β-Lactamase-inhibitor combinations in the 21st century: current agents and new developments by Miller, Linda A., Ratnam, Kapila, Payne, David J.

“…Combinations of β-lactams and β-lactamase inhibitors have become one of the most successful antibacterial strategies in our global battle against bacterial…”
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The Arginine 276 Anchor for NADP(H) Dictates Fluorescence Kinetic Transients in 3α-Hydroxysteroid Dehydrogenase, a Representative Aldo−Keto Reductase by Ratnam, Kapila, Ma, Haiching, Penning, Trevor M

“…Fluorescence stopped-flow studies were conducted with recombinant rat liver 3α-HSD, an aldo-keto reductase (AKR) that plays critical roles in steroid hormone…”
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Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) by Penning, Trevor M., Burczynski, Michael E., Jez, Joseph M., Lin, Hseuh-Kung, Ma, Haiching, Moore, Margaret, Ratnam, Kapila, Palackal, Nisha

“…17β-Hydroxysteroid dehydrogenase (17β-HSD) type 5 has been cloned from human prostate and is identical to type 2 3α-HSD and is a member of the aldo-keto…”
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Mutation of Nicotinamide Pocket Residues in Rat Liver 3α-Hydroxysteroid Dehydrogenase Reveals Different Modes of Cofactor Binding by Ma, Haiching, Ratnam, Kapila, Penning, Trevor M

“…Rat liver 3α-hydroxysteroid dehydrogenase (3α-HSD), an aldo−keto reductase, binds NADP+ in an extended anti-conformation across an (α/β)8-barrel. The…”
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Retention of NADPH-Linked Quinone Reductase Activity in an Aldo-Keto Reductase Following Mutation of the Catalytic Tyrosine by Schlegel, Brian P, Ratnam, Kapila, Penning, Trevor M

“…Aldo-keto reductases (AKR) are monomeric oxidoreductases that retain a conserved catalytic tetrad (Tyr, Lys, Asp, and His) at their active sites in which the…”
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Identification and characterization of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from the Gram-positive pathogen Streptococcus pneumoniae by SYLVESTER, Daniel R., ALVAREZ, Emilio, PATEL, Arun, RATNAM, Kapila, KALLENDER, Howard, WALLIS, Nicola G.

“…The UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from a Gram-positive pathogen, Streptococcus pneumoniae, was identified and characterized. The enzyme…”
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Identification and characterization of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from the Gram-positive pathogen Streptococcus pneumoniae by Sylvester, D R, Alvarez, E, Patel, A, Ratnam, K, Kallender, H, Wallis, N G

“…The UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from a Gram-positive pathogen, Streptococcus pneumoniae, was identified and characterized. The enzyme…”
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Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1–AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones by PENNING, Trevor M., BURCZYNSKI, Michael E., JEZ, Joseph M., HUNG, Chien-Fu, LIN, Hseuh-Kung, MA, Haiching, MOORE, Margaret, PALACKAL, Nisha, RATNAM, Kapila

“…The kinetic parameters, steroid substrate specificity and identities of reaction products were determined for four homogeneous recombinant human…”
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Spectroscopic and kinetic characterization of the recombinant cytochrome c reductase fragment of nitrate reductase. Identification of the rate-limiting catalytic step by Ratnam, K, Shiraishi, N, Campbell, W H, Hille, R

“…The recombinant NADH-cytochrome c reductase fragment of spinach NADH-nitrate reductase (EC 1.6.6.1), consisting of the contiguous heme-containing cytochrome b…”
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Spectroscopic and kinetic characterization of oxomolybdenum enzymes by Ratnam, Kapila

“…A comparative study has been undertaken of two oxomolybdenum enzymes, xanthine dehydrogenase and nitrate reductase. The pH dependence of the redox-active…”
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Paradoxical stabilization of the neutral flavin semiquinone of xanthine dehydrogenase at high pH by Ratnam, K, Hille, R

“…The pH dependence of the behavior of chicken liver xanthine dehydrogenase in the course of reductive titrations with sodium dithionite has been examined. Below…”
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Purification of xanthine dehydrogenase and sulfite oxidase from chicken liver by Ratnam, K, Brody, M S, Hille, R

“…Xanthine dehydrogenase and sulfite oxidase from chicken liver are oxomolybdenum enzymes which catalyze the oxidation of xanthine to uric acid and sulfite to…”
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