Search Results - "RATHOD, Pradipsinh K"

Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network by Cui, Liwang, Mharakurwa, Sungano, Ndiaye, Daouda, Rathod, Pradipsinh K, Rosenthal, Philip J

“…Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases in the global malaria burden are likely due, in part, to the…”
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Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach by Wassmer, Samuel C, Taylor, Terrie E, Rathod, Pradipsinh K, Mishra, Saroj K, Mohanty, Sanjib, Arevalo-Herrera, Myriam, Duraisingh, Manoj T, Smith, Joseph D

“…More than a century after the discovery of Plasmodium spp. parasites, the pathogenesis of severe malaria is still not well understood. The majority of malaria…”
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Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Deng, Xiaoyi, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, Burrows, Jeremy N, Kaminsky, Werner, Charman, Susan A, Matthews, David, Rathod, Pradipsinh K, Phillips, Margaret A

“…Malaria is one of the most serious global infectious diseases. The pyrimidine biosynthetic enzyme Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH)…”
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Plasmodium vivax infection compromises reticulocyte stability by Clark, Martha A., Kanjee, Usheer, Rangel, Gabriel W., Chery, Laura, Mascarenhas, Anjali, Gomes, Edwin, Rathod, Pradipsinh K., Brugnara, Carlo, Ferreira, Marcelo U., Duraisingh, Manoj T.

“…The structural integrity of the host red blood cell (RBC) is crucial for propagation of Plasmodium spp . during the disease-causing blood stage of malaria…”
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Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications by Guler, Jennifer L, Freeman, Daniel L, Ahyong, Vida, Patrapuvich, Rapatbhorn, White, John, Gujjar, Ramesh, Phillips, Margaret A, DeRisi, Joseph, Rathod, Pradipsinh K

“…Malaria drug resistance contributes to up to a million annual deaths. Judicious deployment of new antimalarials and vaccines could benefit from an…”
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Tetrahydro-2-naphthyl and 2‑Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity by Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L, Coteron, Jose M, Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R, Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N, Matthews, Dave, Charman, Susan A, Phillips, Margaret A, Rathod, Pradipsinh K

“…Malaria persists as one of the most devastating global infectious diseases. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) has been…”
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Development of a Plasmodium vivax biobank for functional ex vivo assays by Dash, Rashmi, Skillman, Kristen M, Pereira, Ligia, Mascarenhas, Anjali, Dass, Sheena, Walke, Jayashri, Almeida, Anvily, Fernandes, Mezia, Gomes, Edwin, White, John, Chery-Karschney, Laura, Khandeparkar, Anar, Rathod, Pradipsinh K, Duraisingh, Manoj T, Kanjee, Usheer

“…Background Plasmodium vivax is the second most prevalent cause of malaria yet remains challenging to study due to the lack of a continuous in vitro culture…”
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Bioisosteric Transformations and Permutations in the Triazolopyrimidine Scaffold To Identify the Minimum Pharmacophore Required for Inhibitory Activity against Plasmodium falciparum Dihydroorotate Dehydrogenase by Marwaha, Alka, White, John, El_Mazouni, Farah, Creason, Sharon A, Kokkonda, Sreekanth, Buckner, Frederick S, Charman, Susan A, Phillips, Margaret A, Rathod, Pradipsinh K

“…Plasmodium falciparum causes approximately 1 million deaths annually. However, increasing resistance imposes a continuous threat to existing drug therapies. We…”
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Low genetic diversity of 'Plasmodium vivax' circumsporozoite surface protein in clinical isolates from southern Thailand by Khulmanee, Tachin, Thita, Thanyapit, Kritsiriwutinan, Kanyanan, Boonyuen, Usa, Saai, Aminoh, Inkabjan, Kanjana, Chakrabarti, Rimi, Rathod, Pradipsinh K, Krudsood, Srivicha, Mungthin, Mathirut, Patrapuvich, Rapatbhorn

“…The genetic diversity within the circumsporozoite surface protein (PvCSP) of 'Plasmodium vivax', the predominant malaria species in Thailand, is primarily…”
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Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds by Deng, Xiaoyi, Gujjar, Ramesh, El Mazouni, Farah, Kaminsky, Werner, Malmquist, Nicholas A., Goldsmith, Elizabeth J., Rathod, Pradipsinh K., Phillips, Margaret A.

“…Malaria remains a major global health burden and current drug therapies are compromised by resistance. Plasmodium falciparum dihydroorotate dehydrogenase…”
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A Microfluidic Model for Single-Cell Capillary Obstruction by Plasmodium falciparum-Infected Erythrocytes by Shelby, J. Patrick, White, John, Ganesan, Karthikeyan, Rathod, Pradipsinh K., Chiu, Daniel T.

“…Severe malaria by Plasmodium falciparum is a potentially fatal disease, frequently unresponsive to even the most aggressive treatments. Host organ failure is…”
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Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications by Hostetler, Jessica B, Lo, Eugenia, Kanjee, Usheer, Amaratunga, Chanaki, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Yewhalaw, Delenasaw, Mascarenhas, Anjali, Kwiatkowski, Dominic P, Ferreira, Marcelo U, Rathod, Pradipsinh K, Yan, Guiyun, Fairhurst, Rick M, Duraisingh, Manoj T, Rayner, Julian C

“…Plasmodium vivax causes the majority of malaria episodes outside Africa, but remains a relatively understudied pathogen. The pathology of P. vivax infection…”
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Multiplex Assays for Analysis of Antibody Responses to South Asian Plasmodium falciparum and Plasmodium vivax Malaria Infections by Momoh, Elizabeth O, Ghag, Sonam K, White, John, Mudeppa, Devaraja G, Rathod, Pradipsinh K

“…Malaria remains a major global health challenge, causing over 0.6 million yearly deaths. To understand naturally acquired immunity in adult human populations…”
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Optimization of Plasmodium vivax sporozoite production from Anopheles stephensi in South West India by Mohanty, Ajeet Kumar, de Souza, Charles, Harjai, Deepika, Ghavanalkar, Prathamesh, Fernandes, Mezia, Almeida, Anvily, Walke, Jayashri, Manoharan, Suresh Kumar, Pereira, Ligia, Dash, Rashmi, Mascarenhas, Anjali, Gomes, Edwin, Thita, Thanyapit, Chery, Laura, Anvikar, Anupkumar R, Kumar, Ashwani, Valecha, Neena, Rathod, Pradipsinh K, Patrapuvich, Rapatbhorn

“…Efforts to study the biology of Plasmodium vivax liver stages, particularly the latent hypnozoites, have been hampered by the limited availability of P. vivax…”
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Microfluidic modeling of cell-cell interactions in malaria pathogenesis by Antia, Meher, Herricks, Thurston, Rathod, Pradipsinh K

“…The clinical outcomes of human infections by Plasmodium falciparum remain highly unpredictable. A complete understanding of the complex interactions between…”
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Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy by Phillips, Margaret A, Rathod, Pradipsinh K

“…Malaria remains a globally prevalent infectious disease that leads to significant morbidity and mortality. While there are a number of drugs approved for its…”
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Hospital-derived antibody profiles of malaria patients in Southwest India by Venkatesh, Apoorva, Jain, Aarti, Davies, Huw, Periera, Ligia, Maki, Jennifer N, Gomes, Edwin, Felgner, Philip L, Srivastava, Sanjeeva, Patankar, Swati, Rathod, Pradipsinh K

“…Naturally acquired immunity to malaria across the globe varies in intensity and protective powers. Many of the studies on immunity are from hyperendemic…”
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Susceptibility of wild and colonized Anopheles stephensi to Plasmodium vivax infection by Mohanty, Ajeet Kumar, Nina, Praveen Balabaskaran, Ballav, Shuvankar, Vernekar, Smita, Parkar, Sushma, D'souza, Maria, Zuo, Wenyun, Gomes, Edwin, Chery, Laura, Tuljapurkar, Shripad, Valecha, Neena, Rathod, Pradipsinh K, Kumar, Ashwani

“…As much as 80% of global Plasmodium vivax infections occur in South Asia and there is a shortage of direct studies on infectivity of P. vivax in Anopheles…”
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Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor by Guler, Jennifer L, White, 3rd, John, Phillips, Margaret A, Rathod, Pradipsinh K

“…Atovaquone is a component of Malarone, a widely prescribed antimalarial combination, that targets malaria respiration. Here we show that parasites with…”
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High-throughput Screening for Potent and Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase by Baldwin, Jeffrey, Michnoff, Carolyn H., Malmquist, Nicholas A., White, John, Roth, Michael G., Rathod, Pradipsinh K., Phillips, Margaret A.

“…Plasmodium falciparum is the causative agent of the most serious and fatal malarial infections, and it has developed resistance to commonly employed…”
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