Search Results - "RAPP, LAURENCE M"

Lutein and Zeaxanthin Concentrations in Rod Outer Segment Membranes from Perifoveal and Peripheral Human Retina by Rapp, Laurence M, Maple, Seema S, Choi, Jung H

“…In addition to acting as an optical filter, macular (carotenoid) pigment has been hypothesized to function as an antioxidant in the human retina by inhibiting…”
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Photoreceptor-specific degeneration caused by tunicamycin by Fliesler, Steven J, Rapp, Laurence M, Hollyfield, Joe G

“…The antibiotic tunicamycin inhibits the biosynthesis of N-acetylglucosaminylpyrophosphoryl polyisoprenol, a key intermediate in the formation of the…”
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Influence of UVA Light Stress on Photoreceptor Cell Metabolism: Decreased Rates of Rhodopsin Regeneration and Opsin Synthesis by RAPP, LAURENCE M, GHALAYINI, ABBOUD J

“…There is considerable evidence indicating that rhodopsin is the chromophore mediating light damage to the rat retina caused by exposure to mid-visible…”
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In vivo biosynthesis of cholesterol in the rat retina by Fliesler, Steven J., Florman, Richard, Rapp, Laurence M., Pittler, Steven J., Keller, R.Kennedy

“…Previous reports have suggested that the rate of de novo cholesterol synthesis in the adult vertebrate retina is extremely slow. We investigated cholesterol…”
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In vivo Requirement of Protein Prenylation for Maintenance of Retinal Cytoarchitecture and Photoreceptor Structure by Pittler, Steven J., Fliesler, Steven J., Fisher, Patricia L., Keller, R. Kennedy, Rapp, Laurence M.

“…Recent studies have demonstrated that inhibition of mevalonate synthesis in cultured cells leads to altered cell morphology due to inhibition of protein…”
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Rhodopsin content and electroretinographic sensitivity in light-damaged rat retina by RAPP, LAURENCE M, WILLIAMS, THEODORE P

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Effect of dietary fat on the response of the rat retina to chronic and acute light stress by Koutz, Cynthia A., Wiegand, Rex D., Rapp, Laurence. M., Anderson, Robert E.

“…We designed an experiment to study the role of light history and polyunsaturated fatty acids (PUFA) on the susceptibility of the albino rat retina to light…”
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Evaluation of retinal susceptibility to light damage in pigmented rats supplemented with beta-carotene by Rapp, L M, Fisher, P L, Suh, D W

“…The present study evaluated the influence of beta-carotene supplementation on the susceptibility of the retina to light damage. Long-Evans pigmented rats were…”
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Antiviral Activity and Ocular Kinetics of Antisense Oligonucleotides Designed to Inhibit CMV Replication by Henry, Scott P, Miner, Richard C, Drew, W. Lawrence, Fitchett, Jon, York-Defalco, Cathy, Rapp, Laurence M, Levin, Arthur A

“…To compare the antiviral activity and ocular distribution of first- and second-generation antisense oligonucleotides intended for the treatment of…”
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Free radicals and ocular disease by Anderson, R E, Kretzer, F L, Rapp, L M

“…Ames, Shigenaga, and Hagen recently published a thorough review of the relationship between oxidants, antioxidants, and degenerative diseases of ageing. They…”
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Evidence against melanin as the mediator of retinal phototoxicity by short-wavelength light by Rapp, L M, Smith, S C

“…Albino and pigmented (black-hooded) rats of the Sprague-Dawley and Long Evans strains, respectively, were compared in terms of their susceptibility to retinal…”
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Lipid peroxidation and retinal degeneration by Anderson, R E, Rapp, L M, Wiegand, R D

“…Retinal degenerations were produced in albino rats by exposure to constant illumination or in frogs and albino rats by intravitreal injections of ferrous…”
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Novel morphological changes in rat retina induced by intravitreal injection of lovastatin by Pittler, S J, Fliesler, S J, Rapp, L M

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Impact of lipofuscin on the retinal pigment epithelium: electroretinographic evaluation of a protease inhibition model by RAPP, L. M, FISHER, P. L, SHEINBERG, C. H

“…With aging, the retinal pigment epithelium (RPE) becomes increasingly congested with residual debris called lipofuscin. Little is known about the impact of…”
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Predisposing factors to light-induced photoreceptor cell damage: retinal changes in maturing rats by Rapp, L M, Tolman, B L, Koutz, C A, Thum, L A

“…Retinal changes occurring during the period of growth and maturation of Long Evans pigmented rats were examined to obtain a better understanding of the basis…”
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Synergism between environmental lighting and taurine depletion in causing photoreceptor cell degeneration by Rapp, L M, Thum, L A, Anderson, R E

“…Experiments were conducted to examine the possible interaction between retinal taurine depletion and environmental lighting in causing photoreceptor cell…”
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