Search Results - "RAPOSO, R"
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Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine's Tool Box
Published in Molecules (Basel, Switzerland) (16-09-2015)“…The majority of heterocycle compounds and typically common heterocycle fragments present in most pharmaceuticals currently marketed, alongside with their…”
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Orthodontic camouflage versus orthodontic-orthognathic surgical treatment in class II malocclusion: a systematic review and meta-analysis
Published in International journal of oral and maxillofacial surgery (01-04-2018)“…This systematic review was performed to compare dental, skeletal, and aesthetic outcomes between orthodontic camouflage and surgical-orthodontic treatment, in…”
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Enhancement of water solubility of poorly water-soluble drugs by new biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids
Published in European journal of pharmaceutics and biopharmaceutics (01-04-2019)“…[Display omitted] The major challenge of the pharmaceutical industry is to find potential solvents for poorly water-soluble drug molecules. Ionic liquids (ILs)…”
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Tumor Microenvironment Modulation via Gold Nanoparticles Targeting Malicious Exosomes: Implications for Cancer Diagnostics and Therapy
Published in International journal of molecular sciences (14-01-2017)“…Exosomes are nanovesicles formed in the endosomal pathway with an important role in paracrine and autocrine cell communication. Exosomes secreted by cancer…”
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Genome-Wide Identification of Saccharomyces cerevisiae Genes Required for Maximal Tolerance to Ethanol
Published in Applied and Environmental Microbiology (01-09-2009)“…The understanding of the molecular basis of yeast resistance to ethanol may guide the design of rational strategies to increase process performance in…”
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In Vitro and In Vivo Effect of Palladacycles: Targeting A2780 Ovarian Carcinoma Cells and Modulation of Angiogenesis
Published in Inorganic chemistry (15-03-2021)“…Palladacycles are versatile organometallic compounds that show potential for therapeutic use. Here are described the synthesis and characterization of mono-…”
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Antiproliferative Activities of Diimine-Based Mixed Ligand Copper(II) Complexes
Published in ACS combinatorial science (10-02-2020)“…A series of Cu(diimine)(X-sal)(NO3) complexes, where the diimine is either 2,2′-bipyridine (bpy) or 1,10-phenanthroline (phen) and X-sal is a monoanionic…”
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Gold-nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis
Published in Nanotoxicology (01-08-2014)“…Abstract Antisense therapy is a powerful tool for post-transcriptional gene silencing suitable for down-regulating target genes associated to disease. Gold…”
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Citral Inhibits the Inflammatory Response and Hyperalgesia in Mice: The Role of TLR4, TLR2/Dectin-1, and CB2 Cannabinoid Receptor/ATP-Sensitive K+ Channel Pathways
Published in Journal of natural products (Washington, D.C.) (24-04-2020)“…Citral ((2E)-3,7-dimethylocta-2,6-dienal), a bioactive component of lemongrass, inhibits oxidant activity, nuclear factor kappa B (NF-κB) activation, and…”
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Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor
Published in Biomolecules (Basel, Switzerland) (20-05-2020)“…Depression has a multifactorial etiology that arises from environmental, psychological, genetic, and biological factors. Environmental stress and genetic…”
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Use of alumina sludge arising from an electrocoagulation process as functional mesoporous microcapsules for active corrosion protection of aluminum
Published in Progress in organic coatings (01-02-2021)“…[Display omitted] •Mesoporous alumina particles were produced from electrocoagulated metal hydroxide sludge (EMHS).•Corrosion inhibitors (8-hydroxyquinoline…”
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Diaporthe diversity and pathogenicity revealed from a broad survey of grapevine diseases in Europe
Published in Persoonia (30-06-2018)“…Species of Diaporthe are considered important plant pathogens, saprobes, and endophytes on a wide range of plant hosts. Several species are well-known on…”
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Ionic Liquids and Salts from Ibuprofen as Promising Innovative Formulations of an Old Drug
Published in ChemMedChem (06-05-2019)“…Herein we report the synthesis of novel ionic liquids (ILs) and organic salts by combining ibuprofen as anion with ammonium, imidazolium, or pyridinium…”
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Antiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymers
Published in Journal of inorganic biochemistry (01-11-2019)“…The syntheses of the heterometallic sodium and potassium-dioxidovanadium 2D polymers, [NaVO2(1κNOO’;2κO”-L)(H2O)]n(1) and [KVO2(1κNOO’;2κO’;3κO”-L)(EtOH)]n(2)…”
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Necrotic-like BV-2 microglial cell death due to methylmercury exposure
Published in Frontiers in pharmacology (02-11-2022)“…Methylmercury (MeHg) is a dangerous environmental contaminant with strong bioaccumulation in the food chain and neurotoxic properties. In the nervous system,…”
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Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line
Published in Bioorganic & medicinal chemistry (15-01-2021)“…[Display omitted] Cancer is still one of the deadliest diseases worldwide despite the efforts in its early detection and treatment strategies. However, most…”
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Combined cancer therapeutics—Tackling the complexity of the tumor microenvironment
Published in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology (01-09-2021)“…Cancer treatment has yet to find a “silver bullet” capable of selectively and effectively kill tumor cells without damaging healthy cells. Nanomedicine is a…”
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Infection of human keratinocytes by Streptococcus dysgalactiae subspecies dysgalactiae isolated from milk of the bovine udder
Published in Microbes and infection (01-04-2016)“…Streptococcus dysgalactiae subsp. dysgalactiae (SDSD) are considered exclusive animal pathogens; however, a putative zoonotic upper limb cellulitis, a…”
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Scanning microelectrochemical characterization of the effect of polarization on the localized corrosion of 304 stainless steel in chloride solution
Published in Journal of electroanalytical chemistry (Lausanne, Switzerland) (15-08-2014)“…[Display omitted] •Microelectrochemical characterization of the effect of polarization on the localized corrosion of 304 stainless steel.•Spatially-resolved…”
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The increasing threat to European forests from the invasive foliar pine pathogen, Lecanosticta acicola
Published in Forest ecology and management (15-05-2023)“…•Lecanosticta spp.now recorded in 44 countries, mostly in the northern hemisphere.•L. acicola has increased its range, now found in 24 out of 26 European…”
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