Search Results - "RAPOPORT, T. A"

In vitro Formation of the Endoplasmic Reticulum Occurs Independently of Microtubules by a Controlled Fusion Reaction by Dreier, Lars, Rapoport, Tom A.

“…We have established an in vitro system for the formation of the endoplasmic reticulum (ER). Starting from small membrane vesicles prepared from Xenopus laevis…”
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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction by WIERTZ, E. J. H, TORTORELLA, D, BOGYO, M, YU, J, MOTHES, W, JONES, T. R, RAPOPORT, T. A, PLOEGH, H. L

“…The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The…”
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Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane by Görlich, D, Rapoport, T A

“…We have reproduced the process of protein transport across and of protein integration into the mammalian endoplasmic reticulum membrane by the use of…”
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Mutants Affecting the Structure of the Cortical Endoplasmic Reticulum in Saccharomyces cerevisiae by Prinz, William A., Grzyb, Lara, Veenhuis, Marten, Kahana, Jason A., Silver, Pamela A., Rapoport, Tom A.

“…We find that the peripheral ER in Saccharomyces cerevisiae forms a dynamic network of interconnecting membrane tubules throughout the cell cycle, similar to…”
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Predicting the Orientation of Eukaryotic Membrane-Spanning Proteins by Hartmann, Enno, Rapoport, Tom A., Lodish, Harvey F.

“…We have developed a rule to predict the orientation of the first internal signal-anchor sequence in eukaryotic transmembrane proteins synthesized on the rough…”
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Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol by Shamu, C E, Flierman, D, Ploegh, H L, Rapoport, T A, Chau, V

“…The human cytomegalovirus protein US11 induces the dislocation of MHC class I heavy chains from the endoplasmic reticulum (ER) into the cytosol for degradation…”
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Transport of Proteins Across the Endoplasmic Reticulum Membrane by Rapoport, Tom A.

“…The biosynthesis of many eukaryotic proteins requires their transport across the endoplasmic reticulum (ER) membrane. The process can be divided into two…”
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Signal Sequence-Dependent Function of the TRAM Protein during Early Phases of Protein Transport across the Endoplasmic Reticulum Membrane by Voigt, Sabine, Jungnickel, Berit, Hartmann, Enno, Rapoport, Tom A.

“…Cotranslational translocation of proteins across the mammalian ER membrane involves, in addition to the signal recognition particle receptor and the Sec61p…”
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A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation by Görlich, D, Prehn, S, Hartmann, E, Kalies, K U, Rapoport, T A

“…SEC61p is essential for protein translocation across the endoplasmic reticulum membrane of S. cerevisiae. We have found a mammalian homolog that shows more…”
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Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane by Mothes, W., Prehn, S., Rapoport, T.A.

“…We have extended a previously developed photo‐crosslinking approach to systematically probe the protein environment of the secretory protein preprolactin,…”
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Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting by Bacher, Gerald, Lütcke, Henrich, Jungnickel, Berit, Rapoport, Tom A, Dobberstein, Bernhard

“…The signal-recognition particle (SRP) is important for the targeting of many secretory and membrane proteins to the endoplasmic reticulum (ER). Targeting is…”
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Evolutionary conservation of components of the protein translocation complex by Hartmann, Enno, Sommer, Thomas, Prehn, Siegfried, Görlich, Dirk, Jentsch, Stefan, Rapoport, Tom A

“…Protein translocation into the mammalian endoplasmic reticulum requires the Sec61p complex, which consists of three membrane proteins. The alpha-subunit, the…”
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Retro-translocation of proteins from the endoplasmic reticulum into the cytosol by Rapoport, Tom A, Tsai, Billy, Ye, Yihong

“…Proteins that are misfolded in the endoplasmic reticulum are transported back into the cytosol for destruction by the proteasome. This retro-translocation…”
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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol by Rapoport, Tom A, Ye, Yihong, Meyer, Hemmo H

“…In eukaryotic cells, incorrectly folded proteins in the endoplasmic reticulum (ER) are exported into the cytosol and degraded by the proteasome. This pathway…”
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Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence by High, S, Martoglio, B, Görlich, D, Andersen, S S, Ashford, A J, Giner, A, Hartmann, E, Prehn, S, Rapoport, T A, Dobberstein, B

“…A chemically charged amber suppressor tRNA was used to introduce the photoactivatable amino acid (Tmd)Phe at a selected position within the signal sequence of…”
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X-ray structure of a protein-conducting channel by Rapoport, Tom A, Berg, Bert van den, Clemons, William M, Collinson, Ian, Modis, Yorgo, Hartmann, Enno, Harrison, Stephen C

“…A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms a protein-conducting channel, allowing polypeptides to be transferred…”
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A protein of the endoplasmic reticulum involved early in polypeptide translocation by Görlich, Dirk, Hartmann, Enno, Prehn, Siegfried, Rapoport, Tom A

“…To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were…”
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Binding of Ribosomes to the Rough Endoplasmic Reticulum Mediated by the Sec61p-Complex by Kalies, Kai-Uwe, Görlich, Dirk, Rapoport, Tom A.

“…The cotranslational translocation of proteins across the ER membrane involves the tight binding of translating ribosomes to the membrane, presumably to…”
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Gangliosides are receptors for murine polyoma virus and SV40 by Tsai, Billy, Gilbert, Joanna M., Stehle, Thilo, Lencer, Wayne, Benjamin, Thomas L., Rapoport, Tom A.

“…Polyoma virus (Py) and simian virus 40 (SV40) travel from the plasma membrane to the endoplasmic reticulum (ER) from where they enter the cytosol and then the…”
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Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera Toxin by Tsai, Billy, Rodighiero, Chiara, Lencer, Wayne I., Rapoport, Tom A.

“…Cholera toxin is assembled from two subunits in the periplasm of Vibrio cholerae and disassembled in the analogous compartment of target cells, the lumen of…”
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