Search Results - "RANSOM, R. W"

Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor by Hess, J F, Borkowski, J A, Young, G S, Strader, C D, Ransom, R W

“…A human BK-2 bradykinin receptor was cloned from the lung fibroblast cell line CCD-16Lu. The cDNA clone encodes a 364 amino acid protein that has the…”
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Cooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines by Ransom, R W, Stec, N L

“…In extensively washed rat cortical membranes [3H](+)-5-methyl-10,11-dihydro-5 H-dibenzo [a,d]cyclohepten-5,10-imine ([3H]MK-801) labeled a homogeneous set of…”
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Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates by Turner, D M, Ransom, R W, Yang, J S, Olsen, R W

“…The steroid anesthetic alphaxalone and a series of naturally occurring analogs were compared in potency and efficacy with each other and the hypnotic…”
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Differential pharmacology of cloned human and mouse B2 bradykinin receptors by Hess, J F, Borkowski, J A, Macneil, T, Stonesifer, G Y, Fraher, J, Strader, C D, Ransom, R W

“…The pharmacology of cloned B2 bradykinin receptors heterologously expressed in cell lines lacking any endogenous bradykinin receptors was analyzed. The…”
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Expression cloning of a human B1 bradykinin receptor by Menke, J G, Borkowski, J A, Bierilo, K K, MacNeil, T, Derrick, A W, Schneck, K A, Ransom, R W, Strader, C D, Linemeyer, D L, Hess, J F

“…A cDNA clone encoding a human B1 bradykinin receptor was isolated from a human embryonic lung fibroblast cDNA library by expression cloning. The photoprotein…”
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In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia by Barrow, J C, Nantermet, P G, Selnick, H G, Glass, K L, Rittle, K E, Gilbert, K F, Steele, T G, Homnick, C F, Freidinger, R M, Ransom, R W, Kling, P, Reiss, D, Broten, T P, Schorn, T W, Chang, R S, O'Malley, S S, Olah, T V, Ellis, J D, Barrish, A, Kassahun, K, Leppert, P, Nagarathnam, D, Forray, C

“…alpha(1) Adrenergic receptors mediate both vascular and lower urinary tract tone, and alpha(1) receptor antagonists such as terazosin (1b) are used to treat…”
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Bradykinin stimulation of phosphoinositide hydrolysis in guinea‐pig ileum longitudinal muscle by Ransom, Richard W., Goodman, Carl B., Young, Gretchen S.

“…1 Bradykinin (BK)‐induced contraction of ileal smooth muscle is assumed to be due to phosphoinositide hydrolysis but this has never been reported. We have…”
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Glycine modulation of NMDA-evoked release of [3H]acetylcholine and [3H]dopamine from rat striatal slices by Ransom, R W, Deschenes, N L

“…Superfused slices of rat striatum were used to investigate whether N-methyl-D-aspartate (NMDA) receptors mediating [3H]acetylcholine (ACh) and [3H]dopamine…”
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Polyamine and ifenprodil interactions with the NMDA receptor's glycine site by Ransom, R W

“…Ifenprodil partially inhibited [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor in rat telencephalic membranes. The polyamine spermine…”
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NMDA-induced hippocampal [3H]norepinephrine release is modulated by glycine by Ransom, R W, Deschenes, N L

“…Kynurenic acid (KYN) non-competitively inhibited N-methyl-D-aspartate (NMDA)-induced [3H]norepinephrine ([3H]NE) release from rat hippocampal slices. At 100…”
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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones by Nagarathnam, D, Miao, S W, Lagu, B, Chiu, G, Fang, J, Murali Dhar, T G, Zhang, J, Tyagarajan, S, Marzabadi, M R, Zhang, F, Wong, W C, Sun, W, Tian, D, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Ransom, R W, Schorn, T W, Chen, T B, O'Malley, S, Kling, P, Schneck, K, Bendesky, R, Harrell, C M

“…Dihydropyrimidinones such as compound 12 exhibited high binding affinity and subtype selectivity for the cloned human alpha(1a) receptor. Systematic…”
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[3H]muscimol photolabels the gamma-aminobutyric acid receptor binding site on a peptide subunit distinct from that labeled with benzodiazepines by Deng, L, Ransom, R W, Olsen, R W

“…Affinity column-purified GABA-benzodiazepine receptor protein from bovine brain was photoaffinity labeled with both [3H]flunitrazepam and [3H]muscimol. Gel…”
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[125I]PIP HOE 140, a high affinity radioligand for bradykinin B2 receptors by Brenner, N J, Stonesifer, G Y, Schneck, K A, Burns, H D, Ransom, R W

“…A high affinity radioligand for bradykinin B2 receptors was prepared by coupling an activated ester of [125I]4-iodobenzoic acid to the amino terminus nitrogen…”
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Cloning and pharmacological characterization of bradykinin receptors by Hess, J F, Borkowski, J A, Stonesifer, G Y, MacNeil, T, Strader, C D, Ransom, R W

“…A human B2 bradykinin receptor cDNA was cloned from the lung fibroblast cell line, CCD-Lu. This clone was utilized to isolate a genomic clone of a mouse B2…”
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Cyclopsychotride A, a Biologically Active, 31-Residue Cyclic Peptide Isolated from Psychotria longipes by Witherup, Keith M, Bogusky, Michael J, Anderson, Paul S, Ramjit, Harri, Ransom, Richard W, Wood, Theresa, Sardana, Mohinder

“…A preliminary characterization is provided of a naturally occurring cyclic peptide with interesting and potent biological activity. A 31-residue cyclic…”
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Inhibition of N-methyl-D-aspartate evoked sodium flux by MK-801 by Ransom, R W, Stec, N L

“…The inhibition of N-methyl-D-aspartate (NMDA) stimulated 22Na+ efflux from rat hippocampal slices was studied using competitive and non-competitive receptor…”
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[3H]1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine: a selective radioligand for 5-HT1A receptors in rat brain by Ransom, R W, Asarch, K B, Shih, J C

“…1-[2-(4-Aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (PAPP) inhibits [3H]5-hydroxytryptamine (5-HT, serotonin) binding to 5-HT1A and 5-HT1B sites…”
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The alpha carbon oxidation of some phencyclidine analogues by rat tissue and its pharmacological implications by Stefek, M, Ransom, R W, DiStefano, E W, Cho, A K

“…1. The metabolism of phencyclidine (PCP) and three congeners, differing in the structure of the amine moiety, by liver microsomes from phenobarbital-pretreated…”
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Photoinactivation of serotonin uptake by an arylazido derivative of 5-hydroxytryptamine by Ransom, R W, Lee, J D, Bolger, M B, Shih, J C

“…A potential photoaffinity probe for the substrate-binding polypeptide of the neuronal serotonin uptake system has been synthesized. Under dark conditions,…”
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Xylamine, an irreversible inhibitor of norepinephrine uptake, is transported by this same uptake mechanism in cultured rat superior cervical ganglia by Fischer, J B, Waggaman, L A, Ransom, R W, Cho, A K

“…The accumulation of tritium-labeled xylamine ([3H]XYL), an irreversible inhibitor of neuronal norepinephrine (NE) uptake, was studied in organ-cultured rat…”
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