Search Results - "RANSOHOFF, R. M"

Effect of plasma exchange in accelerating natalizumab clearance and restoring leukocyte function by KHARRI, B. O, MAN, S, DUDA, P. W, PANZARA, M. A, RANSOHOFF, R. M, FOX, R. J, GIOVANNONI, G, KOO, A. P, LEE, J.-C, TUCKY, B, LYNN, F, JURGENSEN, S, WOODWORTH, J, GOELZ, S

“…Accelerating the clearance of therapeutic monoclonal antibodies (mAbs) from the body may be useful to address uncommon but serious complications from…”
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The Chemokine System in Neuroinflammation: An Update by Ransohoff, R. M.

“…Chemokines and their receptors govern physiologic and pathologic leukocyte trafficking. The function of the chemokine system may be of particular interest for…”
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Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats by Walters, M J, Ebsworth, K, Berahovich, R D, Penfold, M E T, Liu, S-C, Al Omran, R, Kioi, M, Chernikova, S B, Tseng, D, Mulkearns-Hubert, E E, Sinyuk, M, Ransohoff, R M, Lathia, J D, Karamchandani, J, Kohrt, H E K, Zhang, P, Powers, J P, Jaen, J C, Schall, T J, Merchant, M, Recht, L, Brown, J M

“…Background: In experimental models of glioblastoma multiforme (GBM), irradiation (IR) induces local expression of the chemokine CXCL12/SDF-1, which promotes…”
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Fatal PML associated with efalizumab therapy: Insights into integrin αLβ2 in JC virus control by SCHWAB, N, ULZHEIMER, J. C, BRÜCK, W, TOYKA, K. V, RANSOHOFF, R. M, WIENDL, H, FOX, R. J, SCHNEIDER-HOHENDORF, T, KIESEIER, B. C, MONORANU, C. M, STAUGAITIS, S. M, WELCH, W, JILEK, S, DU PASQUIER, R. A

“…Progressive multifocal leukoencephalopathy (PML) has become much more common with monoclonal antibody treatment for multiple sclerosis and other…”
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A case of multiple sclerosis presenting with inflammatory cortical demyelination by POPESCU, B. F. Gh, BUNYAN, R. F, PARISI, J. E, RANSOHOFF, R. M, LUCCHINETTI, C. F

“…To describe a patient presenting with a clinically silent, incidentally found, and pathologically confirmed active demyelinating solitary cortical lesion…”
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CSF Neutrophils Are Implicated in the Development of Vasospasm in Subarachnoid Hemorrhage by Provencio, J. J., Fu, X., Siu, A., Rasmussen, P. A., Hazen, S. L., Ransohoff, R. M.

“…Background Cerebral vasospasm is a significant cause of morbidity in patients after aneurysmal subarachnoid hemorrhage (aSAH). There are few effective…”
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Cortical demyelination in PML and MS : Similarities and differences by MOLL, N. M, RIETSCH, A. M, RANSOHOFF, A. J, COSSOY, M. B, HUANG, D, EICHLER, F. S, TRAPP, B. D, RANSOHOFF, R. M

“…To characterize pathologic changes in the cerebral cortex of patients with multiple sclerosis (MS) and progressive multifocal leukoencephalopathy (PML)…”
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Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses by Menetski, J, Mistry, S, Lu, M, Mudgett, J.S, Ransohoff, R.M, DeMartino, J.A, MacIntyre, D.E, Abbadie, C

“…Abstract Recent findings demonstrate that chemokines, and more specifically CC chemokine ligand 2 (CCL2 or monocyte chemoattractant protein-1), play a major…”
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Three or more routes for leukocyte migration into the central nervous system by Ransohoff, Richard M, Kivisäkk, Pia, Kidd, Grahame

“…Leukocyte migration into and through tissues is fundamental to normal physiology, immunopathology and host defence. Leukocyte entry into the central nervous…”
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Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis by Huang, D R, Wang, J, Kivisakk, P, Rollins, B J, Ransohoff, R M

“…Monocyte chemoattractant protein (MCP)-1 plays a critical role in innate immunity by directing the migration of monocytes into inflammatory sites. Recent data…”
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Effect of statins on clinical and molecular responses to intramuscular interferon beta-1a by RUDICK, R. A, PACE, A, GALETTA, S. L, LUBLIN, F. D, RADUE, E.-W, RANSOHOFF, R. M, RANI, M. R. S, HYDE, R, PANZARA, M, APPACHI, S, SHROCK, J, MAURER, S. L, CALABRESI, P. A, CONFAVREUX, C

“…Findings from a small clinical study suggested that statins may counteract the therapeutic effects of interferon beta (IFNbeta) in patients with…”
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Axonal Transection in the Lesions of Multiple Sclerosis by Trapp, Bruce D, Peterson, John, Ransohoff, Richard M, Rudick, Richard, Mörk, Sverre, Bö, Lars

“…Multiple sclerosis is a disease of the central nervous system characterized by multicentric inflammation and destruction of myelin. The primary cause of…”
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CCR5 expression on macrophages/microglia is associated with early remyelination in multiple sclerosis lesions by Trebst, C, König, F, Ransohoff, RM, Brück, W, Stangel, M

“…Remyelination in multiple sclerosis (MS) occurs spontaneously and extensively. The underlying mechanisms, however, are only partly understood. Findings in…”
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In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis by RUDICK, R. A, RANSOHOFF, R. M, LEE, J.-C, PEPPLER, R, YU, M, MATHISEN, P. M, TUOHY, V. K

“…Recombinant interferon beta (IFNbeta) benefits patients with relapsing remitting multiple sclerosis (MS), but the mechanisms of action are unknown. We studied…”
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Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis by Sørensen, T. L., Ransohoff, R. M., Strieter, R. M., Sellebjerg, F.

“…The chemokine monocyte chemoattractant protein (MCP)‐1/CCL2 and its receptor CCR2 have been strongly implicated in disease pathogenesis in experimental…”
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Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis by Glabinski, AR, Tani, M, Strieter, RM, Tuohy, VK, Ransohoff, RM

“…Chemokines are secreted peptides that exhibit selective chemoattractant properties for target leukocytes. Two subfamilies, alpha- and beta-chemokines, have…”
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Chemokines CXCL10 and CCL2: differential involvement in intrathecal inflammation in multiple sclerosis by Sørensen, T. L., Sellebjerg, F., Jensen, C. V., Strieter, R. M., Ransohoff, R. M.

“…Studies of chemokines in cerebrospinal fluid (CSF) of patients with active multiple sclerosis (MS) have indicated that specific chemokines may have important…”
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Functional expression of CXCR3 in cultured mouse and human astrocytes and microglia by Biber, K, Dijkstra, I, Trebst, C, De Groot, C.J.A, Ransohoff, R.M, Boddeke, H.W.G.M

“…It has been established recently that inflammation of the CNS is accompanied by an expression of chemokines within the CNS. Several lines of evidence suggest…”
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Axon Loss in the Spinal Cord Determines Permanent Neurological Disability in an Animal Model of Multiple Sclerosis by WUJEK, JEROME R, BJARTMAR, CARL, RICHER, EDWARD, RANSOHOFF, RICHARD M, YU, MIN, TUOHY, VINCENT K, TRAPP, BRUCE D

“…Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Most patients undergo an initial relapsing-remitting…”
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Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation? by RANSOHOFF, R. M, TANI, M

“…Hematogenous leukocytes infiltrate the CNS after inflammatory stimuli, including infection, mechanical trauma and excitotoxic neuronal necrosis. However,the…”
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