Search Results - "RANGAN, Vangipuram S."

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab by Ramagopal, Udupi A., Liu, Weifeng, Garrett-Thomson, Sarah C., Bonanno, Jeffrey B., Yan, Qingrong, Srinivasan, Mohan, Wong, Susan C., Bell, Alasdair, Mankikar, Shilpa, Rangan, Vangipuram S., Deshpande, Shrikant, Korman, Alan J., Almo, Steven C.

“…Rational modulation of the immune response with biologics represents one of the most promising and active areas for the realization of new therapeutic…”
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Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models by Sankaranarayanan, Sethu, Barten, Donna M, Vana, Laurel, Devidze, Nino, Yang, Ling, Cadelina, Gregory, Hoque, Nina, DeCarr, Lynn, Keenan, Stefanie, Lin, Alan, Cao, Yang, Snyder, Bradley, Zhang, Bin, Nitla, Magdalena, Hirschfeld, Gregg, Barrezueta, Nestor, Polson, Craig, Wes, Paul, Rangan, Vangipuram S, Cacace, Angela, Albright, Charles F, Meredith, Jr, Jere, Trojanowski, John Q, Lee, Virginia M-Y, Brunden, Kurt R, Ahlijanian, Michael

“…In Alzheimer's disease (AD), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with neuronal loss, is evident in…”
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Universal Affinity Capture Liquid Chromatography-Mass Spectrometry Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies by Kotapati, Srikanth, Passmore, David, Yamazoe, Sayumi, Sanku, Rajesh Kishore Kumar, Cong, Qiang, Poudel, Yam B, Chowdari, Naidu S, Gangwar, Sanjeev, Rao, Chetana, Rangan, Vangipuram S, Cardarelli, Pina M, Deshpande, Shrikant, Strop, Pavel, Dollinger, Gavin, Rajpal, Arvind

“…Antibody drug conjugates (ADCs) can undergo in vivo biotransformation (e.g., payload metabolism, deconjugation) leading to reduced or complete loss of…”
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Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC–MS/MS approach: Assay development, validation, and a case study by Liu, Ang, Kozhich, Alexander, Passmore, David, Gu, Huidong, Wong, Richard, Zambito, Frank, Rangan, Vangipuram S., Myler, Heather, Aubry, Anne-Françoise, Arnold, Mark E., Wang, Jian

“…•A novel hybrid approach to quantitatively measure payload conjugated to Ab is reported.•The assay involves immuno-capture, enzyme cleavage and LC–MS/MS…”
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Pharmacokinetic characterization of BMS-936561, an anti-CD70 antibody-drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans by Wang, Haiqing, Rangan, Vangipuram S., Sung, Mei-Chen, Passmore, David, Kempe, Thomas, Wang, Xiaoli, Thevanayagam, Lourdes, Pan, Chin, Rao, Chetana, Srinivasan, Mohan, Zhang, Qian, Gangwar, Sanjeev, Deshpande, Shrikant, Cardarelli, Pina, Marathe, Punit, Yang, Zheng

“…CD70 is a tumor necrosis factor (TNF)‐like type II integral membrane protein that is transiently expressed on activated T‐ and B‐lymphocytes. Aberrant…”
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Production of human monoclonal antibody in eggs of chimeric chickens by Etches, Robert J, Zhu, Lei, van de Lavoir, Marie-Cecile, Albanese, Jenny, Beenhouwer, David O, Cardarelli, Pina M, Cuison, Severino, Deng, David F, Deshpande, Shrikant, Diamond, Jennifer H, Green, Lynae, Halk, Edward L, Heyer, Babette S, Kay, Robert M, Kerchner, Allyn, Leighton, Philip A, Mather, Christine M, Morrison, Sherie L, Nikolov, Zivko L, Passmore, David B, Pradas-Monne, Alicia, Preston, Benjamin T, Rangan, Vangipuram S, Shi, Mingxia, Srinivasan, Mohan, White, Steven G, Winters-Digiacinto, Peggy, Wong, Susan, Zhou, Wen

“…The tubular gland of the chicken oviduct is an attractive system for protein expression as large quantities of proteins are deposited in the egg, the…”
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An integrated multiplatform bioanalytical strategy for antibody-drug conjugates: a novel case study by Myler, Heather, Rangan, Vangipuram S, Wang, Jian, Kozhich, Alexander, Cummings, Jennifer A, Neely, Robert, Dail, Donna, Liu, Ang, Wang, Bonnie, Vezina, Heather E, Freebern, Wendy, Sung, Mei-Chen, Passmore, David, Deshpande, Shrikant, Kempe, Thomas, Gu, Huidong, Saewert, Mark, Manney, Amy, Lute, John, Zambito, Frank, Wong, Richard L, Piccoli, Steven P, Aubry, Anne-Françoise, Pillutla, Renuka, Arnold, Mark, DeSilva, Binodh

“…The bioanalytical strategy for antibody-drug conjugates (ADC) includes numerous measurements integrally designed to provide comprehensive characterization of…”
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Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance by Nambiar, Dhanya K, Aguilera, Todd, Cao, Hongbin, Kwok, Shirley, Kong, Christina, Bloomstein, Joshua, Wang, Zemin, Rangan, Vangipuram S, Jiang, Dadi, von Eyben, Rie, Liang, Rachel, Agarwal, Sonya, Colevas, A Dimitrios, Korman, Alan, Allen, Clint T, Uppaluri, Ravindra, Koong, Albert C, Giaccia, Amato, Le, Quynh Thu

“…Immune checkpoint inhibitors (ICIs), although promising, have variable benefit in head and neck cancer (HNC). We noted that tumor galectin-1 (Gal1) levels were…”
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A Novel, Fully Human Anti-fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer by Ponath, Paul, Menezes, Daniel, Pan, Chin, Chen, Bing, Oyasu, Miho, Strachan, Debbie, LeBlanc, Heidi, Sun, Huadong, Wang, Xi-Tao, Rangan, Vangipuram S, Deshpande, Shrikant, Cristea, Sandra, Park, Kwon-Sik, Sage, Julien, Cardarelli, Pina M

“…The ganglioside fucosyl-GM1 (FucGM1) is a tumor-associated antigen expressed in a large percentage of human small cell lung cancer (SCLC) tumors, but absent in…”
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Design, Synthesis, and Structure–Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody–Drug Conjugates by Chowdari, Naidu S, Zhang, Yong, McDonald, Ivar, Johnson, Walter, Langley, David R, Sivaprakasam, Prasanna, Mate, Robert, Huynh, Tram, Kotapati, Srikanth, Deshpande, Madhura, Pan, Chin, Menezes, Daniel, Wang, Yichong, Rao, Chetana, Sarma, Ganapathy, Warrack, Bethanne M, Rangan, Vangipuram S, Mei-Chen, Sung, Cardarelli, Pina, Deshpande, Shrikant, Passmore, David, Rampulla, Richard, Mathur, Arvind, Borzilleri, Robert, Rajpal, Arvind, Vite, Gregory, Gangwar, Sanjeev

“…A series of tetrahydroisoquinoline-based benzodiazepine dimers were synthesized and tested for in vitro cytotoxicity against a panel of cancer cell lines…”
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Higher-Order Structure Characterization of NKG2A/CD94 Protein Complex and Anti-NKG2A Antibody Binding Epitopes by Mass Spectrometry-Based Protein Footprinting Strategies by Huang, Richard Y.-C, Wang, Yun, Jhatakia, Amy D, Deng, Andy X, Bee, Christine, Deshpande, Shrikant, Rangan, Vangipuram S, Bezman, Natalie, Gudmundsson, Olafur, Chen, Guodong

“…NK group 2 member A (NKG2A), an immune checkpoint inhibitor, is an emerging therapeutic target in immuno-oncology. NKG2A forms a heterodimer with CD94 on the…”
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Challenges in antibody-drug conjugate discovery: a bioconjugation and analytical perspective by Rao, Chetana, Rangan, Vangipuram S, Deshpande, Shrikant

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Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy by Chowdari, Naidu S., Pan, Chin, Rao, Chetana, Langley, David R., Sivaprakasam, Prasanna, Sufi, Bilal, Derwin, Daniel, Wang, Yichong, Kwok, Eilene, Passmore, David, Rangan, Vangipuram S., Deshpande, Shrikant, Cardarelli, Pina, Vite, Gregory, Gangwar, Sanjeev

“…[Display omitted] Uncialamycin analogs were evaluated as potential cytotoxic agents in an antibody-drug conjugate (ADC) approach to treating human cancer…”
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A quantitative human monoclonal antibody immunoassay using anti-idiotypic antibody as a membrane antigen surrogate with surface-plasmon-resonance detection by Wong, Rosie B., Lee, An-Horng, Rangan, Vangipuram S., Cheng, Kuang-Chuan

“…Biologically active membrane proteins are difficult to isolate. Very often the isolated membrane proteins have low binding affinity or no biological integrity…”
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Biotransformation and stability of antibody-drug conjugates: payload metabolism and linker cleavage delineation by Rangan, Vangipuram S, Myler, Heather, Kozhich, Alexander, Wang, Jian, Randazzo, Renee, Deshpande, Shrikant

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Validation of an integrated series of ligand-binding assays for the quantitative determination of antibody-drug conjugates in biological matrices by Myler, Heather, Rangan, Vangipuram S, Kozhich, Alex, Hoffpauir, Brian, Dail, Donna, Cummings, Jennifer, Saewert, Mark, Manney, Amy, Liu, Ang, Rao, Chetana, Wang, Jian, Pillutla, Renuka, DeSilva, Binodh

“…The bioanalytical strategy for antibody-drug conjugates (ADC) includes multiple integrated measurements of pharmacologically relevant ADC. Three ligand-binding…”
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Cloning, Expression, and Characterization of a Human 4′-Phosphopantetheinyl Transferase with Broad Substrate Specificity by Joshi, Anil K., Zhang, Lei, Rangan, Vangipuram S., Smith, Stuart

“…A single candidate 4′-phosphopantetheine transferase, identified by BLAST searches of the human genome sequence data base, has been cloned, expressed, and…”
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Mapping the Functional Topology of the Animal Fatty Acid Synthase by Mutant Complementation in Vitro by Rangan, Vangipuram S, Joshi, Anil K, Smith, Stuart

“…An in vitro mutant complementation approach has been used to map the functional topology of the animal fatty acid synthase. A series of knockout mutants was…”
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The Human Thioesterase II Protein Binds to a Site on HIV-1 Nef Critical for CD4 Down-regulation by Cohen, George B., Rangan, Vangipuram S., Chen, Benjamin K., Smith, Stuart, Baltimore, David

“…A HIV-1 Nef affinity column was used to purify a 35-kDa Nef-interacting protein from T-cell lysates. The 35-kDa protein was identified by peptide microsequence…”
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Identification of an Inverted CCAAT Box Motif in the Fatty-acid Synthase Gene as an Essential Element for Mediation of Transcriptional Regulation by cAMP by Rangan, Vangipuram S., Oskouian, Babak, Smith, Stuart

“…The antagonistic effect of cAMP on the insulin-induced expression of fatty acid synthase (FAS) in liver could be mimicked in vitro using H4IIE hepatoma cells,…”
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