Search Results - "RANE, Anders"

Use of doping agents, particularly anabolic steroids, in sports and society by Sjöqvist, Folke, Prof, Garle, Mats, Rane, Anders, Prof

“…Summary The use of doping agents, particularly anabolic androgenic steroids (AAS), has changed from being a problem restricted to sports to one of…”
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A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose by Takeuchi, Fumihiko, McGinnis, Ralph, Bourgeois, Stephane, Barnes, Chris, Eriksson, Niclas, Soranzo, Nicole, Whittaker, Pamela, Ranganath, Venkatesh, Kumanduri, Vasudev, McLaren, William, Holm, Lennart, Lindh, Jonatan, Rane, Anders, Wadelius, Mia, Deloukas, Panos

“…We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish subjects) is sufficiently powered to detect genome-wide significance…”
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The Inhibitory Effect of Telmisartan on the Metabolism of Arachidonic Acid by CYP2C9 and CYP2C8: An in Vitro Study by Kato, Yuka, Mukai, Yuji, Rane, Anders, Inotsume, Nobuo, Toda, Takaki

“…Epoxyeicosatorienoic acids (EETs) are generated from arachidonic acid (AA) by CYPs. EETs comprise four regioisomers (14,15-, 11,12-, 8,9-, and 5,6-EET). EETs…”
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The largest prospective warfarin-treated cohort supports genetic forecasting by Wadelius, Mia, Chen, Leslie Y., Lindh, Jonatan D., Eriksson, Niclas, Ghori, Mohammed J.R., Bumpstead, Suzannah, Holm, Lennart, McGinnis, Ralph, Rane, Anders, Deloukas, Panos

“…Genetic variants of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose, but the effect of other genes…”
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Influence of CYP2C9 genotype on warfarin dose requirements--a systematic review and meta-analysis by Lindh, Jonatan D, Holm, Lennart, Andersson, Marine L, Rane, Anders

“…Purpose To quantify the influence of common cytochrome P450 2C9 (CYP2C9) polymorphisms on warfarin dose requirements. Methods A systematic review and a…”
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A supraphysiological dose of testosterone induces nitric oxide production and oxidative stress by Skogastierna, Cristine, Hotzen, Maja, Rane, Anders, Ekström, Lena

“…Background Accumulating evidence indicates that abuse of anabolic androgenic steroids may cause cardiovascular adverse side-effects, including endothelial…”
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Co-administration of Fluvastatin and CYP3A4 and CYP2C8 Inhibitors May Increase the Exposure to Fluvastatin in Carriers of CYP2C9 Genetic Variants by Mukai, Yuji, Narita, Masayuki, Akiyama, Erika, Ohashi, Kanami, Horiuchi, Yasutaka, Kato, Yuka, Toda, Takaki, Rane, Anders, Inotsume, Nobuo

“…Fluvastatin, which is one of the hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins), is primarily metabolized by CYP2C9 and to a lesser extent…”
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Losartan Competitively Inhibits CYP2C8-Dependent Paclitaxel Metabolism in Vitro by Mukai, Yuji, Toda, Takaki, Hayakawa, Toru, Eliasson, Erik, Rane, Anders, Inotsume, Nobuo

“…The present study aimed to characterize the inhibitory effects of losartan, an angiotensin II receptor blocker, on CYP2C8. Inhibition experiments were based on…”
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DNA methylation dynamics in the hepatic CYP3A4 gene promoter by Kacevska, Marina, Ivanov, Maxim, Wyss, Annika, Kasela, Silva, Milani, Lili, Rane, Anders, Ingelman-Sundberg, Magnus

“…The CYP3A4 gene, encoding the major drug metabolizing enzyme in humans, exhibits a high interindividual variation in hepatic expression that can lead to…”
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Effects of angiotensin II receptor blockers on serum levels of epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids in patients admitted to a cardiovascular center by Kato, Yuka, Senda, Asuna, Mukai, Yuji, Yamashita, Miki, Sasaoka, Yuki, Hanada, Minayo, Hongo, Fuminori, Hirokami, Mitsugu, Rane, Anders, Inotsume, Nobuo, Toda, Takaki

“…Purpose Several clinical studies have demonstrated that angiotensin-converting enzyme inhibitors, but not angiotensin II receptor blockers (ARBs), reduce the…”
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Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz by Wang, Jue, Sönnerborg, Anders, Rane, Anders, Josephson, Filip, Lundgren, Stefan, Ståhle, Lars, Ingelman-Sundberg, Magnus

“…The non-nucleoside reverse transcriptase inhibitor efavirenz is mainly metabolised by the polymorphic cytochrome P450 enzyme CYP2B6. Genomic DNA from four…”
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Vitamin D receptor rs2228570 polymorphism is associated with LH levels in men exposed to anabolic androgenic steroids by Björkhem-Bergman, Linda, Lehtihet, Mikael, Rane, Anders, Ekström, Lena

“…The primary aim of this study was to investigate the association between the vitamin D receptor polymorphisms rs2228570 (Fok1) and rs731236 (TaqI) and LH and…”
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Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract by Thörn, Mari, Finnström, Niklas, Lundgren, Stefan, Rane, Anders, Lööf, Lars

“…Aim The aim of this study was to quantify the mRNA expression of three cytochromes P450 (CYP) and P‐glycoprotein (P‐gp) in the human gastrointestinal (GI)…”
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Angiotensin II Receptor Blockers Inhibit the Generation of Epoxyeicosatrienoic Acid from Arachidonic Acid in Recombinant CYP2C9, CYP2J2 and Human Liver Microsomes by Senda, Asuna, Mukai, Yuji, Hayakawa, Toru, Kato, Yuka, Eliasson, Erik, Rane, Anders, Toda, Takaki, Inotsume, Nobuo

“…Cytochrome P450 (CYP) 2C9, CYP2C8 and CYP2J2 enzymes, which metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids, have cardioprotective effects…”
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Male Anabolic Androgenic Steroid Users with Personality Disorders Report More Aggressive Feelings, Suicidal Thoughts, and Criminality by Börjesson, Annica, Möller, Christian, Hagelin, Anders, Vicente, Veronica, Rane, Anders, Lehtihet, Mikael, Dahl, Marja-Liisa, Gårevik, Nina, Ekström, Lena

“…Anabolic androgenic steroids (AAS) are mainly used for aesthetic and performance-enhancing reasons. Their use is a growing public health problem and concern…”
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Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8 by Senda, Asuna, Mukai, Yuji, Toda, Takaki, Hayakawa, Toru, Yamashita, Miki, Eliasson, Erik, Rane, Anders, Inotsume, Nobuo

“…Arachidonic acid (AA) is metabolized to epoxyeicosatrienoic acids (EETs) via cytochrome enzymes such as CYP 2C9, 2C8 and 2J2. EETs play a role in…”
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Simultaneous Determination Method of Epoxyeicosatrienoic Acids and Dihydroxyeicosatrienoic Acids by LC-MS/MS System by Mukai, Yuji, Toda, Takaki, Takeuchi, Satoya, Senda, Asuna, Yamashita, Miki, Eliasson, Erik, Rane, Anders, Inotsume, Nobuo

“…Epoxyeicosatrienoic acids (EETs) are produced primarily by CYPs from arachidonic acid (AA) and then further metabolized to the corresponding…”
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The Role of CYP2C8 and CYP2C9 Genotypes in Losartan‐Dependent Inhibition of Paclitaxel Metabolism in Human Liver Microsomes by Mukai, Yuji, Senda, Asuna, Toda, Takaki, Eliasson, Erik, Rane, Anders, Inotsume, Nobuo

“…The aim of the present study was to further investigate a previously identified metabolic interaction between losartan and paclitaxel, which is one of the…”
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EXPRESSION OF CYP3A ISOFORMS AND P-GLYCOPROTEIN IN HUMAN STOMACH, JEJUNUM AND ILEUM by Canaparo, Roberto, Finnström, Niklas, Serpe, Loredana, Nordmark, Anna, Muntoni, Elisabetta, Eandi, Mario, Rane, Anders, Zara, Gian Paolo

“…SUMMARY 1 CYP3A isoforms metabolise a diverse array of clinically important drugs and P‐glycoprotein (P‐gp), a transmembrane efflux pump, can extrude a wide…”
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Radical prostatectomy: Influence on serum and urinary androgen levels by Olsson, Mats, Ekström, Lena, Schulze, Jenny, Kjellman, Anders, Akre, Olof, Rane, Anders, Gustafsson, Ove

“…BACKGROUND The role of the prostate as an active endocrine organ and the hormonal changes after radical prostatectomy (RP) has not been well studied. The…”
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