Search Results - "RANDOLPH, Aaron"

Experimental factors that impact CaV1.2 channel pharmacology-Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the "step-step-ramp" voltage protocol by Ren, Ming, Randolph, Aaron L, Alvarez-Baron, Claudia, Guo, Donglin, Tran, Phu N, Thiebaud, Nicolas, Sheng, Jiansong, Zhao, Jun, Wu, Wendy W

“…CaV1.2 channels contribute to action potential upstroke in pacemaker cells, plateau potential in working myocytes, and initiate excitation-contraction…”
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Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block by Tran, Phu N, Sheng, Jiansong, Randolph, Aaron L, Baron, Claudia Alvarez, Thiebaud, Nicolas, Ren, Ming, Wu, Min, Johannesen, Lars, Volpe, Donna A, Patel, Dakshesh, Blinova, Ksenia, Strauss, David G, Wu, Wendy W

“…Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction. QTC prolongation that crosses the 10 msec threshold of regulatory…”
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Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative by Li, Zhihua, Ridder, Bradley J., Han, Xiaomei, Wu, Wendy W., Sheng, Jiansong, Tran, Phu N., Wu, Min, Randolph, Aaron, Johnstone, Ross H., Mirams, Gary R., Kuryshev, Yuri, Kramer, James, Wu, Caiyun, Crumb, William J., Strauss, David G.

“…The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs are…”
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Experimental factors that impact Ca V 1.2 channel pharmacology—Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the “step-step-ramp” voltage protocol by Ren, Ming, Contributed equally to this work with: Ming Ren, Aaron L. Randolph Aaron L. Randolph, Randolph, Aaron, Guo, Donglin, Tran, Phu, Thiebaud, Nicolas, Sheng, Jiansong, Zhao, Jun, Wu, Wendy

“…Background and purpose Ca V 1.2 channels contribute to action potential upstroke in pacemaker cells, plateau potential in working myocytes, and initiate…”
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Drug potency on inhibiting late Na+ current is sensitive to gating modifier and current region where drug effects were measured by Wu, Min, Tran, Phu N., Sheng, Jiansong, Randolph, Aaron L., Wu, Wendy W.

“…Cardiac late Na+ current (INaL) contributes to ventricular action potential duration. Pathological increase in INaL is arrhythmogenic, and inhibition of INaL…”
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Proton currents constrain structural models of voltage sensor activation by Randolph, Aaron L, Mokrab, Younes, Bennett, Ashley L, Sansom, Mark Sp, Ramsey, Ian Scott

“…The Hv1 proton channel is evidently unique among voltage sensor domain proteins in mediating an intrinsic 'aqueous' H conductance (G ). Mutation of a highly…”
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Decoy peptide targeted to Toll-IL-1R domain inhibits LPS and TLR4-active metabolite morphine-3 glucuronide sensitization of sensory neurons by Allette, Yohance M., Kim, Youngsook, Randolph, Aaron L., Smith, Jared A., Ripsch, Matthew S., White, Fletcher A.

“…Accumulating evidence indicates that Toll-like receptor (TLR) signaling adapter protein interactions with Toll/Interleukin-1 Receptor (TIR) domains present in…”
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Carbamazepine potentiates the effectiveness of morphine in a rodent model of neuropathic pain by Due, Michael R, Yang, Xiao-Fang, Allette, Yohance M, Randolph, Aaron L, Ripsch, Matthew S, Wilson, Sarah M, Dustrude, Erik T, Khanna, Rajesh, White, Fletcher A

“…Approximately 60% of morphine is glucuronidated to morphine-3-glucuronide (M3G) which may aggravate preexisting pain conditions. Accumulating evidence…”
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There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments by Rapedius, Markus, Obergrussberger, Alison, Humphries, Edward S A, Scholz, Stephanie, Rinke-Weiss, Ilka, Goetze, Tom A, Brinkwirth, Nina, Rotordam, Maria Giustina, Strassmaier, Tim, Randolph, Aaron, Friis, Søren, Liutkute, Aiste, Seibertz, Fitzwilliam, Voigt, Niels, Fertig, Niels

“…Fluoride has been used in the internal recording solution for manual and automated patch clamp experiments for decades because it helps to improve the seal…”
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Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene by KANG, Dong-Chul, GOPALKRISHNAN, Rahul V, LIN LIN, RANDOLPH, Aaron, VALERIE, Kristoffer, PESTKA, Sidney, FISHER, Paul B

“…Melanoma differentiation associated gene-5 (mda-5) was identified by subtraction hybridization as a novel upregulated gene in HO-1 human melanoma cells induced…”
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Unique aspects of mda-7/IL-24 antitumor bystander activity : establishing a role for secretion of MDA-7/IL-24 protein by normal cells by ZHAOZHONG SU, EMDAD, Luni, DENT, Paul, FISHER, Paul B, SAUANE, Moira, LEBEDEVA, Irina V, SARKAR, Devanand, GUPTA, Pankaj, JAMES, C. David, RANDOLPH, Aaron, VALERIE, Kirstoffer, WALTER, Mark R

“…Melanoma differentiation associated gene-7 (mda-7) was cloned using subtraction hybridization from terminally differentiated human melanoma cells. Based on…”
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mda-9/Syntenin : A positive regulator of melanoma metastasis by BOUKERCHE, Habib, SU, Zao-Zhong, EMDAD, Luni, BARIL, Patrick, BALME, Brigitte, THOMAS, Luc, RANDOLPH, Aaron, VALENE, Kristoffer, SARKAR, Devanand, FISHER, Paul B

“…Metastasis is a significant event in cancer progression and continues to pose the greatest challenge for a cancer cure. Defining genes that control metastasis…”
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Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways by SAUANE, Moira, LEBEDEVA, Irina V, SU, Zao-Zhong, CHOO, Heng-Tong, RANDOLPH, Aaron, VALERIE, Kristoffer, DENT, Paul, GOPALKRISHNAN, Rahul V, FISHER, Paul B

“…Melanoma differentiation associated gene-7/interleukin-24 (Mda-7/IL-24), a novel member of the IL-10 family of cytokines, uniquely displays cancer-specific…”
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Targeting Gene Expression Selectively in Cancer Cells by Using the Progression-Elevated Gene-3 Promoter by Su, Zhao-Zhong, Sarkar, Devanand, Emdad, Luni, Duigou, Gregory J., Charles S. H. Young, Ware, Joy, Randolph, Aaron, Valerie, Kristoffer, Fisher, Paul B., Todaro, George J.

“…One impediment to effective cancer-specific gene therapy is the rarity of regulatory sequences targeting gene expression selectively in tumor cells. Although…”
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Defining the Domains of Human Polynucleotide Phosphorylase (hPNPaseOLD-35) Mediating Cellular Senescence by Sarkar, Devanand, Park, Eun Sook, Emdad, Luni, Randolph, Aaron, Valerie, Kristoffer, Fisher, Paul B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Experimental factors that impact Ca.sub.V1.2 channel pharmacology-Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the "step-step-ramp" voltage protocol by Ren, Ming, Randolph, Aaron L, Alvarez-Baron, Claudia, Guo, Donglin, Tran, Phu N, Thiebaud, Nicolas, Sheng, Jiansong, Zhao, Jun, Wu, Wendy W

“…Background and purpose Ca.sub.V 1.2 channels contribute to action potential upstroke in pacemaker cells, plateau potential in working myocytes, and initiate…”
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Electromechanical Coupling in Gating of the Hv1 Voltage Sensor is Revealed by Resting-State Currents in an S4 Arg to His Mutation (R205H) by Ramsey, I. Scott, Randolph, Aaron L.

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Editor's Note: mda-9 /Syntenin: A Positive Regulator of Melanoma Metastasis by Boukerche, Habib, Su, Zao-Zhong, Emdad, Luni, Baril, Patrick, Balme, Brigitte, Thomas, Luc, Randolph, Aaron, Valerie, Kristoffer, Sarkar, Devanand, Fisher, Paul B.

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A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm by Ridder, Bradley J., Leishman, Derek J., Bridgland-Taylor, Matthew, Samieegohar, Mohammadreza, Han, Xiaomei, Wu, Wendy W., Randolph, Aaron, Tran, Phu, Sheng, Jiansong, Danker, Timm, Lindqvist, Anders, Konrad, Daniel, Hebeisen, Simon, Polonchuk, Liudmila, Gissinger, Evgenia, Renganathan, Muthukrishnan, Koci, Bryan, Wei, Haiyang, Fan, Jingsong, Levesque, Paul, Kwagh, Jae, Imredy, John, Zhai, Jin, Rogers, Marc, Humphries, Edward, Kirby, Robert, Stoelzle-Feix, Sonja, Brinkwirth, Nina, Rotordam, Maria Giustina, Becker, Nadine, Friis, Søren, Rapedius, Markus, Goetze, Tom A., Strassmaier, Tim, Okeyo, George, Kramer, James, Kuryshev, Yuri, Wu, Caiyun, Himmel, Herbert, Mirams, Gary R., Strauss, David G., Bardenet, Rémi, Li, Zhihua

“…hERG block potency is widely used to calculate a drug's safety margin against its torsadogenic potential. Previous studies are confounded by use of different…”
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Activation of the nuclear factor κB pathway by astrocyte elevated gene-1 : Implications for tumor progression and metastasis by EMDAD, Luni, SARKAR, Devanand, SU, Zao-Zhong, RANDOLPH, Aaron, BOUKERCHE, Habib, VALERIC, Kristoffer, FISHER, Paul B

“…Abstract Astrocyte elevated gene-1 (AEG-1) was initially identified as an HIV-1- and tumor necrosis factor α (TNF-α)–inducible transcript in primary human…”
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