Search Results - "RANDLE, John Cr"

Inactivation of Caspase‐1 in Rodent Brain: A Novel Anticonvulsive Strategy by Ravizza, Teresa, Lucas, Sian‐Marie, Balosso, Silvia, Bernardino, Liliana, Ku, George, Noé, Francesco, Malva, Joao, Randle, John C. R., Allan, Stuart, Vezzani, Annamaria

“…Purpose: Cytokines and related inflammatory mediators are rapidly synthesized in the brain during seizures. We previously found that intracerebral…”
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IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients by Stack, Jeffrey H, Beaumont, Kevin, Larsen, Paul D, Straley, Kimberly S, Henkel, Greg W, Randle, John C. R, Hoffman, Hal M

“…Familial cold autoinflammatory syndrome (FCAS) and the related autoinflammatory disorders, Muckle-Wells syndrome and neonatal onset multisystem inflammatory…”
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Rapid decrease of wild-type hepatitis C virus on telaprevir treatment by ADIWIJAYA, Bambang S, HARE, Brian, CARON, Paul R, RANDLE, John Cr, NEUMANN, Avidan U, REESINK, Hendrik W, ZEUZEM, Stefan, HERRMANN, Eva

“…Telaprevir (TVR) is a hepatitis C virus (HCV) NS3.4A protease inhibitor that has exhibited antiviral activity in patients with HCV genotype 1 infection. The…”
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A Multi-Variant, Viral Dynamic Model of Genotype 1 HCV to Assess the in vivo Evolution of Protease-Inhibitor Resistant Variants: e1000745 by Adiwijaya, Bambang S, Herrmann, Eva, Hare, Brian, Kieffer, Tara, Lin, Chao, Kwong, Ann D, Garg, Varun, Randle, John CR, Sarrazin, Christoph, Zeuzem, Stefan, Caron, Paul R

“…Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the…”
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Open-label phase 1b pilot study to assess the antiviral efficacy of simvastatin combined with sertraline in chronic hepatitis C patients by Patel, Keyur, Lim, Seng G, Cheng, Chow W, Lawitz, Eric, Tillmann, Hans L, Chopra, Narinder, Altmeyer, Ralf, Randle, John C R, McHutchison, John G

“…3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors inhibit HCV replication in vitro. The combination of sertraline and simvastatin has synergistic…”
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ICE/Caspase-1 inhibitors as novel anti-inflammatory drugs by Randle, J C, Harding, M W, Ku, G, Schönharting, M, Kurrle, R

“…In recent years, several strategies that selectively inhibit pro-inflammatory cytokines, have yielded effective protein-based therapies for inflammatory…”
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