Search Results - "RANDLE, C"

Time and the Visibility of Slow Atrocity Violence by DeFalco, Randle C

“…Abstract This article explores the role of time in obfuscating the criminality of international crimes committed through the cumulative effects of various…”
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Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y14R Antagonist by Wen, Zhiwei, Salmaso, Veronica, Jung, Young-Hwan, Phung, Ngan B, Gopinatth, Varun, Shah, Qasim, Patterson, Alexandra T, Randle, John C. R, Chen, Zhoumou, Salvemini, Daniela, Lieberman, David I, Whitehead, Gregory S, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A

“…High affinity phenyl-piperidine P2Y14R antagonist 1 (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity…”
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Inactivation of Caspase‐1 in Rodent Brain: A Novel Anticonvulsive Strategy by Ravizza, Teresa, Lucas, Sian‐Marie, Balosso, Silvia, Bernardino, Liliana, Ku, George, Noé, Francesco, Malva, Joao, Randle, John C. R., Allan, Stuart, Vezzani, Annamaria

“…Purpose: Cytokines and related inflammatory mediators are rapidly synthesized in the brain during seizures. We previously found that intracerebral…”
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Structure–Activity Relationship of Heterocyclic P2Y14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres by Jung, Young-Hwan, Salmaso, Veronica, Wen, Zhiwei, Bennett, John M, Phung, Ngan B, Lieberman, David I, Gopinatth, Varun, Randle, John C. R, Chen, Zhoumou, Salvemini, Daniela, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A

“…A known zwitterionic, heterocyclic P2Y14R antagonist 3a was substituted with diverse groups on the central phenyl and terminal piperidine moieties, following a…”
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IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients by Stack, Jeffrey H, Beaumont, Kevin, Larsen, Paul D, Straley, Kimberly S, Henkel, Greg W, Randle, John C. R, Hoffman, Hal M

“…Familial cold autoinflammatory syndrome (FCAS) and the related autoinflammatory disorders, Muckle-Wells syndrome and neonatal onset multisystem inflammatory…”
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Contextualizing 'actus reus' under article 25(3)(d) of the ICC statute: Thresholds of contribution by DeFalco, R. C.

“…Individualizing accountability predicated on group crime is a recurring challenge facing international criminal law (ICL). A major aspect of this struggle…”
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A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants by Adiwijaya, Bambang S, Herrmann, Eva, Hare, Brian, Kieffer, Tara, Lin, Chao, Kwong, Ann D, Garg, Varun, Randle, John C R, Sarrazin, Christoph, Zeuzem, Stefan, Caron, Paul R

“…Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the…”
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Accounting for Famine at the Extraordinary Chambers in the Courts of Cambodia: The Crimes against Humanity of Extermination, Inhumane Acts and Persecution by DeFalco, Randle C

“…Mass famines routinely accompany the commission of violent international crimes during periods of armed conflict or under repressive regimes. Indeed, suffering…”
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King David, son of Jesse: the world's first Parkinson's patient ...observations from November 2013 by Voyles, C Randle

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Outdoor learning in formal ecological education: looking to the future by Oberbillig, Dave, Randle, DC, Middendorf, George, Cardelús, Catherine L

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Early Treatment with Vigabatrin Does Not Decrease Focal Seizures or Improve Cognition in Tuberous Sclerosis Complex: The PREVeNT Trial by Bebin, Elizabeth Martina, Peters, Jurriaan M., Porter, Brenda E., McPherson, Tarrant O., O'Kelley, Sarah, Sahin, Mustafa, Taub, Katherine S., Rajaraman, Rajsekar, Randle, Stephanie C., McClintock, William M., Koenig, Mary Kay, Frost, Mike D., Northrup, Hope A., Werner, Klaus, Nolan, Danielle A., Wong, Michael, Krefting, Jessica L., Biasini, Fred, Peri, Kalyani, Cutter, Gary, Krueger, Darcy A.

“…Objective This study was undertaken to test the hypothesis that early vigabatrin treatment in tuberous sclerosis complex (TSC) infants improves neurocognitive…”
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You, your patient, and the medical-device industry: applications from my Louisville years by Voyles, C. Randle

“…Hiram C. Polk, Jr, M.D.—forever to be known as “The Boss”—is retiring as Chair of the University of Louisville Department of Surgery after 33 years where he…”
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Meta-analysis of laparoscopic inguinal hernia trials favors open hernia repair with preperitoneal mesh prosthesis by Voyles, C.Randle, Hamilton, Brian J, Johnson, William D, Kano, Nobuyasu

“…Background: This meta-analysis was performed to determine the degree to which improvements in open hernia repair (OHR) in the last decade have altered the…”
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Isolation and characterization of polymorphic microsatellite loci for the three-toed box turtle (Terrapene carolina triunguis) and cross-amplification in other Terrapene species by BUCHMAN, A. B., DEATON, R., RANDLE, C. P., BRUMMEL, T., WILSON, E. D., LUTTERSCHMIDT, W. I.

“…We isolated and characterized eight polymorphic microsatellite loci for a Texas population of three‐toed box turtle, Terrapene carolina triunguis, using a…”
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Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y 14 Receptor Antagonists by Wen, Zhiwei, Pramanik, Asmita, Lewicki, Sarah A, Jung, Young-Hwan, Gao, Zhan-Guo, Randle, John C R, Cronin, Chunxia, Chen, Zhoumou, Giancotti, Luigino A, Whitehead, Gregory S, Liang, Bruce T, Breton, Sylvie, Salvemini, Daniela, Cook, Donald N, Jacobson, Kenneth A

“…P2Y receptor (P2Y R) is activated by extracellular UDP-glucose, a damage-associated molecular pattern that promotes inflammation in the kidney, lung, fat…”
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Alicyclic Ring Size Variation of 4‑Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists by Wen, Zhiwei, Pramanik, Asmita, Lewicki, Sarah A., Jung, Young-Hwan, Gao, Zhan-Guo, Randle, John C. R., Cronin, Chunxia, Chen, Zhoumou, Giancotti, Luigino A., Whitehead, Gregory S., Liang, Bruce T., Breton, Sylvie, Salvemini, Daniela, Cook, Donald N., Jacobson, Kenneth A.

“…P2Y14 receptor (P2Y14R) is activated by extracellular UDP-glucose, a damage-associated molecular pattern that promotes inflammation in the kidney, lung, fat…”
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Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y 14 R Antagonist by Wen, Zhiwei, Salmaso, Veronica, Jung, Young-Hwan, Phung, Ngan B, Gopinatth, Varun, Shah, Qasim, Patterson, Alexandra T, Randle, John C R, Chen, Zhoumou, Salvemini, Daniela, Lieberman, David I, Whitehead, Gregory S, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A

“…High affinity phenyl-piperidine P2Y R antagonist (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various…”
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Deep Brain Stimulation of Bilateral Centromedian Thalamic Nuclei in Pediatric Patients with Lennox-Gastaut Syndrome: An Institutional Experience by Bonda, David, Kelly, Katherine A., Boop, Scott, Feroze, Abdullah H., Randle, Stephanie C., Bindschadler, Mike, Marashly, Ahmad, Owens, James, Lockrow, Jason, Bozarth, Xiuhua, Novotny, Edward, Friedman, Seth, Goldstein, Hannah E., Grannan, Benjamin L., Durfy, Sharon, Ojemann, Jeffrey G., Ko, Andrew L., Hauptman, Jason S.

“…Surgical management of pediatric patients with nonlesional, drug-resistant epilepsy, including patients with Lennox-Gastaut syndrome (LGS), remains a challenge…”
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Structure-Activity Relationship of Heterocyclic P2Y 14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres by Jung, Young-Hwan, Salmaso, Veronica, Wen, Zhiwei, Bennett, John M, Phung, Ngan B, Lieberman, David I, Gopinatth, Varun, Randle, John C R, Chen, Zhoumou, Salvemini, Daniela, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A

“…A known zwitterionic, heterocyclic P2Y R antagonist was substituted with diverse groups on the central phenyl and terminal piperidine moieties, following a…”
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Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X₇ receptor-mediated IL-1β release by Bernardino, Liliana, Balosso, Silvia, Ravizza, Teresa, Marchi, Nicola, Ku, George, Randle, John C, Malva, João O, Vezzani, Annamaria

“…We investigated the consequences of transient application of specific stimuli mimicking inflammation to hippocampal tissue on microglia activation and neuronal…”
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