Search Results - "RANDI, G"

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018 by Ferlay, J., Colombet, M., Soerjomataram, I., Dyba, T., Randi, G., Bettio, M., Gavin, A., Visser, O., Bray, F.

“…Europe contains 9% of the world population but has a 25% share of the global cancer burden. Up-to-date cancer statistics in Europe are key to cancer planning…”
Get full text

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication by Sorensen, C. S., Syljuasen, R. G.

“…Mechanisms that preserve genome integrity are highly important during the normal life cycle of human cells. Loss of genome protective mechanisms can lead to…”
Get full text

Hypoxia-Induced Gene Expression in Chemoradioresistant Cervical Cancer Revealed by Dynamic Contrast-Enhanced MRI by HALLE, Cathinka, ANDERSEN, Erlend, MALINEN, Eirik, LYNG, Heidi, LANDO, Malin, AARNES, Eva-Katrine, HASVOLD, Grete, HOLDEN, Marit, SYLJUASEN, Randi G, SUNDFØR, Kolbein, KRISTENSEN, Gunnar B, HOLM, Ruth

“…Knowledge of the molecular background of functional magnetic resonance (MR) images is required to fully exploit their potential in cancer management. We…”
Get full text

p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775 by Hauge, Sissel, Macurek, Libor, Syljuåsen, Randi G.

“…The Wee1 inhibitor MK1775 (AZD1775) is currently being tested in clinical trials for cancer treatment. Here, we show that the p53 target and CDK inhibitor p21…”
Get full text

A novel, rapid and sensitive flow cytometry method reveals degradation of promoter proximal paused RNAPII in the presence and absence of UV by Bay, Lilli T E, Syljuåsen, Randi G, Landsverk, Helga B

“…Abstract RNA polymerase II (RNAPII) is emerging as an important factor in DNA damage responses, but how it responds to genotoxic stress is not fully…”
Get full text

Multidisciplinary Approach for Managing Complex Pain and Addiction in Primary Care: A Qualitative Study by Sokol, Randi G, Pines, Rachyl, Chew, Aaronson

“…PURPOSE Primary care providers (PCPs) may feel ill-equipped to effectively and safely manage patients with chronic pain, an addiction, or both. This study…”
Get full text

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis by Bartek, Jiri, Falck, Jacob, Mailand, Niels, Syljuåsen, Randi G, Lukas, Jiri

“…When exposed to ionizing radiation (IR), eukaryotic cells activate checkpoint pathways to delay the progression of the cell cycle. Defects in the IR-induced…”
Get full text

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair by Bartek, Jiri, Helleday, Thomas, Sørensen, Claus Storgaard, Hansen, Lasse Tengbjerg, Dziegielewski, Jaroslaw, Syljuåsen, Randi G, Lundin, Cecilia

“…The essential checkpoint kinase Chk1 is required for cell-cycle delays after DNA damage or blocked DNA replication. However, it is unclear whether Chk1 is…”
Get full text

Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and polo-like kinase 1 kinases by SYLJUASEN, Randi G, JENSEN, Sanne, BARTEK, Jiri, LUKAS, Jiri

“…Checkpoint adaptation was originally defined in yeast as the ability to divide despite the presence of damaged DNA. An important unanswered question is whether…”
Get full text

Expanding roles of cell cycle checkpoint inhibitors in radiation oncology by Hauge, Sissel, Eek Mariampillai, Adrian, Rødland, Gro Elise, Bay, Lilli T. E., Landsverk, Helga B., Syljuåsen, Randi G.

“…Radiation-induced activation of cell cycle checkpoints have been of long-standing interest. The WEE1, CHK1 and ATR kinases are key factors in cell cycle…”
Get full text

Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases by Eek Mariampillai, Adrian, Hauge, Sissel, Kongsrud, Karoline, Syljuåsen, Randi G

“…Inhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair. Recent studies suggest that ATR inhibitors…”
Get full text

WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin by Landsverk, Helga B., Sandquist, Lise E., Bay, Lilli T.E., Steurer, Barbara, Campsteijn, Coen, Landsverk, Ole J.B., Marteijn, Jurgen A., Petermann, Eva, Trinkle-Mulcahy, Laura, Syljuåsen, Randi G.

“…Transcription-replication (T-R) conflicts cause replication stress and loss of genome integrity. However, the transcription-related processes that restrain…”
Get full text

Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating by Eisele, Markus R., Reed, Randi G., Rudack, Till, Schweitzer, Andreas, Beck, Florian, Nagy, Istvan, Pfeifer, Günter, Plitzko, Jürgen M., Baumeister, Wolfgang, Tomko, Robert J., Sakata, Eri

“…The proteasome is the central protease for intracellular protein breakdown. Coordinated binding and hydrolysis of ATP by the six proteasomal ATPase subunits…”
Get full text

Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage by Syljuåsen, Randi G., Sørensen, Claus Storgaard, Hansen, Lasse Tengbjerg, Fugger, Kasper, Lundin, Cecilia, Johansson, Fredrik, Helleday, Thomas, Sehested, Maxwell, Lukas, Jiri, Bartek, Jiri

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading by Hauge, Sissel, Naucke, Christian, Hasvold, Grete, Joel, Mrinal, Rødland, Gro Elise, Juzenas, Petras, Stokke, Trond, Syljuåsen, Randi G

“…Recent studies have shown synergistic cytotoxic effects of simultaneous Chk1- and Wee1-inhibition. However, the mechanisms behind this synergy are not known…”
Get full text

A novel role for ATR/Rad3 in G1 phase by Bøe, Cathrine A., Håland, Tine W., Boye, Erik, Syljuåsen, Randi G., Grallert, Beáta

“…Checkpoint kinases are important in cellular surveillance pathways that help cells to cope with DNA damage and protect their genomes. In cycling cells, DNA…”
Get full text

Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1 by Landsverk, Helga B, Sandquist, Lise E, Sridhara, Sreerama C, Rødland, Gro Elise, Sabino, João C, de Almeida, Sérgio F, Grallert, Beata, Trinkle-Mulcahy, Laura, Syljuåsen, Randi G

“…Abstract Ataxia telangiectasia mutated and Rad3-related (ATR) kinase is a key factor activated by DNA damage and replication stress. An alternative pathway for…”
Get full text

Interstitial lung diseases in a lung cancer screening trial by SVERZELLATI, N, GUERCI, L, RANDI, G, CALABRO, E, LA VECCHIA, C, MARCHIANO, A, PESCI, A, ZOMPATORI, M, PASTORINO, U

“…We assessed the prevalence of interstitial lung disease (ILD) in a cohort of smokers included in a lung cancer screening trial. Two observers independently…”
Get full text

Caspase activation counteracts interferon signaling after G2 checkpoint abrogation by ATR inhibition in irradiated human cancer cells by Eek Mariampillai, Adrian, Hauge, Sissel, Øynebråten, Inger, Rødland, Gro Elise, Corthay, Alexandre, Syljuåsen, Randi G.

“…Recent studies suggest that inhibition of the ATR kinase can potentiate radiation-induced antitumor immune responses, but the extent and mechanisms of such…”
Get full text

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase by Bartek, Jiri, Krämer, Alwin, Mailand, Niels, Lukas, Claudia, Syljuåsen, Randi G, Wilkinson, Christopher J, Nigg, Erich A, Lukas, Jiri

“…Entry into mitosis occurs after activation of Cdk1, resulting in chromosome condensation in the nucleus and centrosome separation, as well as increased…”
Get full text