Search Results - "RAMSEY, Gwendolyn"

Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the Potential Treatment of Obesity and Diabetes by Qian, Yimin, Wertheimer, Stanley J, Ahmad, Mushtaq, Cheung, Adrian Wai-Hing, Firooznia, Fariborz, Hamilton, Matthew M, Hayden, Stuart, Li, Shiming, Marcopulos, Nicholas, McDermott, Lee, Tan, Jenny, Yun, Weiya, Guo, Liang, Pamidimukkala, Anjula, Chen, Yingsi, Huang, Kuo-Sen, Ramsey, Gwendolyn B, Whittard, Toni, Conde-Knape, Karin, Taub, Rebecca, Rondinone, Cristina M, Tilley, Jefferson, Bolin, David

“…Diacylglycerol acyltransferase-1 (DGAT-1) is the enzyme that catalyzes the final and committed step of triglyceride formation, namely, the acylation of…”
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Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site by Dunten, Pete, Belunis, Charles, Crowther, Robert, Hollfelder, Kurt, Kammlott, Ursula, Levin, Wayne, Michel, Hanspeter, Ramsey, Gwendolyn B, Swain, Amy, Weber, David, Wertheimer, Stanley J

“…We report crystal structures of the human enzyme phosphoenolpyruvate carboxykinase (PEPCK) with and without bound substrates. These structures are the first to…”
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4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: Drug-like and non-xanthine based A2B adenosine receptor antagonists by Cheung, Adrian Wai-Hing, Brinkman, John, Firooznia, Fariborz, Flohr, Alexander, Grimsby, Joseph, Gubler, Mary Lou, Guertin, Kevin, Hamid, Rachid, Marcopulos, Nicholas, Norcross, Roger D., Qi, Lida, Ramsey, Gwendolyn, Tan, Jenny, Wen, Yang, Sarabu, Ramakanth

“…7-N-Acetamide-4-methoxy-2-aminobenzothiazole 4-fluorobenzamide (compound 1) was chosen as a drug-like and non-xanthine based starting point for the discovery…”
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Discovery of benzothiazole-based adenosine A₂B receptor antagonists with improved A₂A selectivity by Firooznia, Fariborz, Cheung, Adrian Wai-Hing, Brinkman, John, Grimsby, Joseph, Gubler, Mary Lou, Hamid, Rachid, Marcopulos, Nicholas, Ramsey, Gwendolyn, Tan, Jenny, Wen, Yang, Sarabu, Ramakanth

“…The highly potent but modestly selective N-(2-amino-4-methoxy-benzothiazol-7-yl)-N-ethyl-acetamide derivative 2 was selected as the starting point for the…”
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Discovery of benzothiazole-based adenosine A sub(2B receptor antagonists with improved A) sub(2)A selectivity by Firooznia, Fariborz, Cheung, Adrian Wai-Hing, Brinkman, John, Grimsby, Joseph, Gubler, Mary Lou, Hamid, Rachid, Marcopulos, Nicholas, Ramsey, Gwendolyn, Tan, Jenny, Wen, Yang, Sarabu, Ramakanth

“…The highly potent but modestly selective N-(2-amino-4-methoxy-benzothiazol-7-yl)-N-ethyl-acetamide derivative 2 was selected as the starting point for the…”
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Discovery of benzothiazole-based adenosine A 2B receptor antagonists with improved A 2A selectivity by Firooznia, Fariborz, Cheung, Adrian Wai-Hing, Brinkman, John, Grimsby, Joseph, Gubler, Mary Lou, Hamid, Rachid, Marcopulos, Nicholas, Ramsey, Gwendolyn, Tan, Jenny, Wen, Yang, Sarabu, Ramakanth

“…The highly potent but modestly selective N-(2-amino-4-methoxy-benzothiazol-7-yl)- N-ethyl-acetamide derivative 2 was selected as the starting point for the…”
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4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: Drug-like and non-xanthine based A sub(2B) adenosine receptor antagonists by Cheung, Adrian Wai-Hing, Brinkman, John, Firooznia, Fariborz, Flohr, Alexander, Grimsby, Joseph, Gubler, Mary Lou, Guertin, Kevin, Hamid, Rachid, Marcopulos, Nicholas, Norcross, Roger D, Qi, Lida, Ramsey, Gwendolyn, Tan, Jenny, Wen, Yang, Sarabu, Ramakanth

“…7-N-Acetamide-4-methoxy-2-aminobenzothiazole 4-fluorobenzamide (compound 1) was chosen as a drug-like and non-xanthine based starting point for the discovery…”
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C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase by Pietranico, Sherrie L., Foley, Louise H., Huby, Nicholas, Yun, Weiya, Dunten, Pete, Vermeulen, John, Wang, Ping, Toth, Katherine, Ramsey, Gwendolyn, Gubler, Mary-Lou, Wertheimer, Stanley J.

“…Enzyme and cellular assay results for a number of new modifications on the C-8 aminobenzyl unit are reported. Pyrazole sulfonic acid amide analogs are shown to…”
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Modified 3-alkyl-1,8-dibenzylxanthines as GTP-competitive inhibitors of phosphoenolpyruvate carboxykinase by FOLEY, Louise H, PING WANG, DUNTEN, Pete, RAMSEY, Gwendolyn, GUBLER, Mary-Lou, WERTHEIMER, Stanley J

“…The first non-substrate like inhibitors of human cytosolic phosphoenolpyruvate carboxykinase (PEPCK) competitive with GTP are reported. An effort to discover…”
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X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-dibenzylxanthines by FOLEY, Louise H, PING WANG, DUNTEN, Pete, RAMSEY, Gwendolyn, GUBLER, Mary-Lou, WERTHEIMER, Stanley J

“…The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The…”
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Guanine phosphoribosyltransferase from Escherichia coli. Specificity and properties by Miller, Richard L, Ramsey, Gwendolyn A, Krenitsky, Thomas A, Elion, Gertrude B

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