Search Results - "RAMSAY, MICHELE"

African genomic data sharing and the struggle for equitable benefit by Ramsay, Michèle

“…Genomic and related health data from Africa remain scarce and are extremely valuable, due to an abundance of variants often rare or absent in the rest of the…”
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Assessing runs of Homozygosity: a comparison of SNP Array and whole genome sequence low coverage data by Ceballos, Francisco C, Hazelhurst, Scott, Ramsay, Michèle

“…Runs of Homozygosity (ROH) are genomic regions where identical haplotypes are inherited from each parent. Since their first detection due to technological…”
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African genetic diversity and adaptation inform a precision medicine agenda by Pereira, Luisa, Mutesa, Leon, Tindana, Paulina, Ramsay, Michèle

“…The deep evolutionary history of African populations, since the emergence of modern humans more than 300,000 years ago, has resulted in high genetic diversity…”
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Runs of homozygosity: windows into population history and trait architecture by Ceballos, Francisco C., Joshi, Peter K., Clark, David W., Ramsay, Michèle, Wilson, James F.

“…Key Points The inheritance of identical haplotypes from a common ancestor creates long tracts of homozygous genotypes known as runs of homozygosity (ROH). ROH…”
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Marianne Alberts (1928-2020) : caring, compassionate and humble biochemist and pioneer by Ramsay, Michèle

“…Her legacy project was to establish the Dikgale Health and Demographic Surveillance System (DHDSS) and Research Centre in 1995. The DHDSS was a founder member…”
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Africa: Continent of genome contrasts with implications for biomedical research and health by Ramsay, Michèle

“…The genomic architecture of African populations is poorly understood and there is considerable variation between ethno-linguistic groups. Genome-wide…”
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Has translational genomics come of age in Africa? by Kamp, Michelle, Krause, Amanda, Ramsay, Michele

“…Abstract The rapid increase in genomics research in Africa and the growing promise of precision public health (PPH) begs the question of whether African…”
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Genetic and epigenetic insights into fetal alcohol spectrum disorders by Ramsay, Michèle

“…The magnitude of the detrimental effects following in utero alcohol exposure, including fetal alcohol syndrome and other fetal alcohol spectrum disorders…”
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Non-invasive harvesting of conjunctival cells for whole transcriptome sequencing by Hulley, Michaella, Ngcungcu, Thandiswa, Ramsay, Michèle, Williams, Susan

“…The purpose of this study was to determine the feasibility of using a non-invasive technique, the EYEPRIM™ conjunctival cell impression device, to harvest…”
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African partnerships through the H3Africa Consortium bring a genomic dimension to longitudinal population studies on the continent by Ramsay, Michèle, Sankoh, Osman

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Growing genomic research on the African continent: The H3Africa Consortium by Ramsay, Michèle

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Evolutionary genomics in Africa by Ramsay, Michèle, Schlebusch, Carina, Davies, Kay

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Sydney Brenner (1927–2019) : the opening game by Ramsay, Michèle

“…In his memoire, My Life in Science (BioMed Central Limited; 2001), Sydney Brenner described his greatest skill as ‘getting things started’. Throughout his…”
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African genetic diversity provides novel insights into evolutionary history and local adaptations by Choudhury, Ananyo, Aron, Shaun, Sengupta, Dhriti, Hazelhurst, Scott, Ramsay, Michèle

“…Abstract Genetic variation and susceptibility to disease are shaped by human demographic history and adaptation. We can now study the genomes of extant…”
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APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans by Kasembeli, Alex N, Duarte, Raquel, Ramsay, Michèle, Mosiane, Pulane, Dickens, Caroline, Dix-Peek, Thérèse, Limou, Sophie, Sezgin, Efe, Nelson, George W, Fogo, Agnes B, Goetsch, Stewart, Kopp, Jeffrey B, Winkler, Cheryl A, Naicker, Saraladevi

“…APOL1 variants are associated with HIV-associated nephropathy and FSGS in African Americans. The prevalence of these variants in African populations with CKD…”
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Dysregulation of the Wnt signaling pathway in South African patients with diffuse systemic sclerosis by Frost, Jacqueline, Estivill, Xavier, Ramsay, Michèle, Tikly, Mohammed

“…The objective was to explore changes in gene expression in Wnt pathway genes in skin samples of black South Africans with diffuse cutaneous systemic sclerosis…”
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Common and Founder Mutations for Monogenic Traits in Sub-Saharan African Populations by Krause, Amanda, Seymour, Heather, Ramsay, Michèle

“…This review highlights molecular genetic studies of monogenic traits where common pathogenic mutations occur in black families from sub-Saharan Africa…”
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Ancestry-aligned polygenic scores combined with conventional risk factors improve prediction of cardiometabolic outcomes in African populations by Kamp, Michelle, Pain, Oliver, Lewis, Cathryn M, Ramsay, Michèle

“…Cardiovascular diseases (CVD) are a major health concern in Africa. Improved identification and treatment of high-risk individuals can reduce adverse health…”
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The H3Africa policy framework: negotiating fairness in genomics by de Vries, Jantina, Tindana, Paulina, Littler, Katherine, Ramsay, Michèle, Rotimi, Charles, Abayomi, Akin, Mulder, Nicola, Mayosi, Bongani M

“…Human Heredity and Health in Africa (H3Africa) research seeks to promote fair collaboration between scientists in Africa and those from elsewhere. Here, we…”
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Runs of homozygosity in sub-Saharan African populations provide insights into complex demographic histories by Ceballos, Francisco C., Hazelhurst, Scott, Ramsay, Michèle

“…The study of runs of homozygosity (ROH) can shed light on population demographic history and cultural practices. We present a fine-scale ROH analysis of 1679…”
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