Search Results - "RAMETTA, Raffaela"

Genetic and Epigenetic Modifiers of Alcoholic Liver Disease by Meroni, Marica, Longo, Miriam, Rametta, Raffaela, Dongiovanni, Paola

“…Alcoholic liver disease (ALD), a disorder caused by excessive alcohol consumption is a global health issue. More than two billion people consume alcohol in the…”
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Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver by Kim, KyeongJin, Kang, Jin Ku, Jung, Young Hoon, Lee, Sang Bae, Rametta, Raffaela, Dongiovanni, Paola, Valenti, Luca, Pajvani, Utpal B.

“…Increased adiposity confers risk for systemic insulin resistance and type 2 diabetes (T2D), but mechanisms underlying this pathogenic inter-organ crosstalk are…”
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Statin use and non-alcoholic steatohepatitis in at risk individuals by Dongiovanni, Paola, Petta, Salvatore, Mannisto, Ville, Mancina, Rosellina Margherita, Pipitone, Rosaria, Karja, Vesa, Maggioni, Marco, Kakela, Pirjo, Wiklund, Olov, Mozzi, Enrico, Grimaudo, Stefania, Kaminska, Dorota, Rametta, Raffaela, Craxi, Antonio, Fargion, Silvia, Nobili, Valerio, Romeo, Stefano, Pihlajamaki, Jussi, Valenti, Luca

“…Graphical abstract…”
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The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids by Prill, Sebastian, Caddeo, Andrea, Baselli, Guido, Jamialahmadi, Oveis, Dongiovanni, Paola, Rametta, Raffaela, Kanebratt, Kajsa P., Pujia, Arturo, Pingitore, Piero, Mancina, Rosellina Margherita, Lindén, Daniel, Whatling, Carl, Janefeldt, Annika, Kozyra, Mikael, Ingelman-Sundberg, Magnus, Valenti, Luca, Andersson, Tommy B., Romeo, Stefano

“…There is a high unmet need for developing treatments for nonalcoholic fatty liver disease (NAFLD), for which there are no approved drugs today. Here, we used a…”
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The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent by Mancina, Rosellina Margherita, Dongiovanni, Paola, Petta, Salvatore, Pingitore, Piero, Meroni, Marica, Rametta, Raffaela, Borén, Jan, Montalcini, Tiziana, Pujia, Arturo, Wiklund, Olov, Hindy, George, Spagnuolo, Rocco, Motta, Benedetta Maria, Pipitone, Rosaria Maria, Craxì, Antonio, Fargion, Silvia, Nobili, Valerio, Käkelä, Pirjo, Kärjä, Vesa, Männistö, Ville, Pihlajamäki, Jussi, Reilly, Dermot F, Castro-Perez, Jose, Kozlitina, Julia, Valenti, Luca, Romeo, Stefano

“…Background & Aims Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk…”
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Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease by Dongiovanni, Paola, Petta, Salvatore, Maglio, Cristina, Fracanzani, Anna Ludovica, Pipitone, Rosaria, Mozzi, Enrico, Motta, Benedetta Maria, Kaminska, Dorota, Rametta, Raffaela, Grimaudo, Stefania, Pelusi, Serena, Montalcini, Tiziana, Alisi, Anna, Maggioni, Marco, Kärjä, Vesa, Borén, Jan, Käkelä, Pirjo, Di Marco, Vito, Xing, Chao, Nobili, Valerio, Dallapiccola, Bruno, Craxi, Antonio, Pihlajamäki, Jussi, Fargion, Silvia, Sjöström, Lars, Carlsson, Lena M., Romeo, Stefano, Valenti, Luca

“…Excess hepatic storage of triglycerides is considered a benign condition, but nonalcoholic steatohepatitis (NASH) may progress to fibrosis and promote…”
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Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker by Baselli, Guido Alessandro, Dongiovanni, Paola, Rametta, Raffaela, Meroni, Marica, Pelusi, Serena, Maggioni, Marco, Badiali, Sara, Pingitore, Piero, Maurotti, Samantha, Montalcini, Tiziana, Taliento, Alice Emma, Prati, Daniele, Rossi, Giorgio, Fracanzani, Anna Ludovica, Mancina, Rosellina Margherita, Romeo, Stefano, Valenti, Luca

“…Efforts to manage non-alcoholic fatty liver disease (NAFLD) are limited by the incomplete understanding of the pathogenic mechanisms and the absence of…”
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From Environment to Genome and Back: A Lesson from HFE Mutations by Rametta, Raffaela, Meroni, Marica, Dongiovanni, Paola

“…The environment and the human genome are closely entangled and many genetic variations that occur in human populations are the result of adaptive selection to…”
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Patatin‐Like phospholipase domain‐containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C by Valenti, Luca, Rumi, MariaGrazia, Galmozzi, Enrico, Aghemo, Alessio, Del Menico, Benedetta, De Nicola, Stella, Dongiovanni, Paola, Maggioni, Marco, Fracanzani, Anna Ludovica, Rametta, Raffaela, Colombo, Massimo, Fargion, Silvia

“…Steatosis has been reported to negatively influence the natural history of chronic hepatitis C (CHC), but controversy remains over its causal role due to the…”
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A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia by Valenti, Luca, Fracanzani, Anna Ludovica, Dongiovanni, Paola, Rovida, Serena, Rametta, Raffaela, Fatta, Erika, Pulixi, Edoardo Alessandro, Maggioni, Marco, Fargion, Silvia

“…AIM:To compare iron depletion to lifestyle changes alone in patients with severe nonalcoholic fatty liver disease(NAFLD)and hyperferritinemia,a frequent…”
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Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease by Dongiovanni, Paola, Meroni, Marica, Baselli, Guido Alessandro, Bassani, Giulia Alessandra, Rametta, Raffaela, Pietrelli, Alessandro, Maggioni, Marco, Facciotti, Federica, Trunzo, Valentina, Badiali, Sara, Fargion, Silvia, Gatti, Stefano, Valenti, Luca

“…In patients with non-alcoholic fatty liver disease (NAFLD), insulin resistance (IR) associates with fibrosis progression independently of the hepatic…”
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The rs2294918 E434K variant modulates patatin‐like phospholipase domain‐containing 3 expression and liver damage by Donati, Benedetta, Motta, Benedetta Maria, Pingitore, Piero, Meroni, Marica, Pietrelli, Alessandro, Alisi, Anna, Petta, Salvatore, Xing, Chao, Dongiovanni, Paola, del Menico, Benedetta, Rametta, Raffaela, Mancina, Rosellina Margherita, Badiali, Sara, Fracanzani, Anna Ludovica, Craxì, Antonio, Fargion, Silvia, Nobili, Valerio, Romeo, Stefano, Valenti, Luca

“…The patatin‐like phosholipase domain‐containing 3 (PNPLA3) rs738409 polymorphism (I148M) is a major determinant of hepatic fat and predisposes to the full…”
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MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease by Petta, Salvatore, Valenti, Luca, Marra, Fabio, Grimaudo, Stefania, Tripodo, Claudio, Bugianesi, Elisabetta, Cammà, Calogero, Cappon, Andrea, Di Marco, Vito, Di Maira, Giovanni, Dongiovanni, Paola, Rametta, Raffaela, Gulino, Alessandro, Mozzi, Enrico, Orlando, Emanuele, Maggioni, Marco, Pipitone, Rosaria Maria, Fargion, Silvia, Craxì, Antonio

“…Background & Aim Homozygosity for a common non-coding rs4374383 G>A polymorphism in MERTK (myeloid-epithelial-reproductive tyrosine kinase) has been associated…”
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PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients by Dongiovanni, Paola, Meroni, Marica, Baselli, Guido, Mancina, Rosellina M., Ruscica, Massimiliano, Longo, Miriam, Rametta, Raffaela, Cespiati, Annalisa, Pelusi, Serena, Ferri, Nicola, Ranzani, Valeria, Nobili, Valerio, Pihlajamaki, Jussi, Fracanzani, Anna Ludovica, Badiali, Sara, Petta, Salvatore, Fargion, Silvia, Romeo, Stefano, Kozlitina, Julia, Valenti, Luca

“…Dyslipidemia and altered iron metabolism are typical features of nonalcoholic fatty liver disease (NAFLD). Proprotein convertase subtilisin/kexin type 7…”
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The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development--a potential therapeutic target? by Dongiovanni, Paola, Rametta, Raffaela, Meroni, Marica, Valenti, Luca

“…Insulin resistance (IR) is defined by the inability of insulin to exert its metabolic actions, due to impaired activation of intracellular insulin signaling…”
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Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis by Valenti, Luca, Rametta, Raffaela, Dongiovanni, Paola, Maggioni, Marco, Fracanzani, Anna Ludovica, Zappa, Marco, Lattuada, Enzo, Roviaro, Giancarlo, Fargion, Silvia

“…Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis Luca Valenti 1 , Raffaela Rametta 1 , Paola Dongiovanni 1 ,…”
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Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes by Meroni, Marica, Dongiovanni, Paola, Longo, Miriam, Carli, Fabrizia, Baselli, Guido, Rametta, Raffaela, Pelusi, Serena, Badiali, Sara, Maggioni, Marco, Gaggini, Melania, Fracanzani, Anna Ludovica, Romeo, Stefano, Gatti, Stefano, Davidson, Nicholas O., Gastaldelli, Amalia, Valenti, Luca

“…Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol…”
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High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload by Dongiovanni, Paola, Lanti, Claudia, Gatti, Stefano, Rametta, Raffaela, Recalcati, Stefania, Maggioni, Marco, Fracanzani, Anna Ludovica, Riso, Patrizia, Cairo, Gaetano, Fargion, Silvia, Valenti, Luca

“…Increased serum ferritin associated with mild hepatic iron accumulation, despite preserved upregulation of the iron hormone hepcidin, is frequently observed in…”
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Paradoxical Dissociation Between Hepatic Fat Content and De Novo Lipogenesis Due to PNPLA3 Sequence Variant by Mancina, Rosellina M, Matikainen, Niina, Maglio, Cristina, Söderlund, Sanni, Lundbom, Nina, Hakkarainen, Antti, Rametta, Raffaela, Mozzi, Enrico, Fargion, Silvia, Valenti, Luca, Romeo, Stefano, Taskinen, Marja-Riitta, Borén, Jan

“…Context: Nonalcoholic fatty liver disease (NAFLD) is an emerging epidemic disease characterized by increased hepatic fat, due to an imbalance between synthesis…”
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DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70 by Batelli, Sara, Albani, Diego, Rametta, Raffaela, Polito, Letizia, Prato, Francesca, Pesaresi, Marzia, Negro, Alessandro, Forloni, Gianluigi

“…Parkinson's disease (PD) is a neurodegenerative pathology whose molecular etiopathogenesis is not known. Novel contributions have come from familial forms of…”
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