Search Results - "RAMESAR, R"

Genetics of schizophrenia in the South African Xhosa by Gulsuner, S, Stein, D J, Susser, E S, Sibeko, G, Pretorius, A, Walsh, T, Majara, L, Mndini, M M, Mqulwana, S G, Ntola, O A, Casadei, S, Ngqengelele, L L, Korchina, V, van der Merwe, C, Malan, M, Fader, K M, Feng, M, Willoughby, E, Muzny, D, Baldinger, A, Andrews, H F, Gur, R C, Gibbs, R A, Zingela, Z, Nagdee, M, Ramesar, R S, King, M-C, McClellan, J M

“…Africa, the ancestral home of all modern humans, is the most informative continent for understanding the human genome and its contribution to complex disease…”
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The molecular genetics of cognition: dopamine, COMT and BDNF by Savitz, J., Solms, M., Ramesar, R.

“…The important contribution of genetic factors to the development of cognition and intelligence is widely acknowledged, but identification of these genes has…”
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Polygenic risk for schizophrenia and associated brain structural changes: A systematic review by van der Merwe, C., Passchier, R., Mufford, M., Ramesar, R., Dalvie, S., Stein, D.J.

“…Genome wide association studies (GWAS) of schizophrenia allow the generation of Polygenic Risk Scores (PRS). PRS can be used to determine the contribution to…”
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Epigenetics – an introductory overview by Ramesar, R.S.

“…Epigenetics or imprinting refers to the process of ‘chemically’ marking the central A, C, G, T double-stranded DNA code. In the past several decades a deeper…”
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Spondyloepimetaphyseal dysplasia with joint laxity (Beighton type); mutation analysis in eight affected South African families by Vorster, A.A., Beighton, P., Ramesar, R.S.

“…Spondyloepimetaphyseal dysplasia with joint laxity (SEMD‐JL), type 1 is an autosomal recessive disorder which has been identified in more than 30 affected…”
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Namaqualand hip dysplasia in South Africa: The molecular determinant elucidated by Agenbag, G, Vorster, A, Julius, S, Ramesar, R, Beighton, P

“…Namaqualand hip dysplasia (NHD) is a mild form of spondyloepiphyseal dysplasia in which progressive arthropathy of the hip joint is a major manifestation. The…”
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Promoter region variation in NFE2L2 influences susceptibility to ototoxicity in patients exposed to high cumulative doses of cisplatin by Spracklen, T F, Vorster, A A, Ramma, L, Dalvie, S, Ramesar, R S

“…Ototoxicity is a disabling reaction to cisplatin chemotherapy. Much of the inter-individual variability in the development of hearing impairment among…”
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Namaqualand hip dysplasia in South Africa : the molecular determinant elucidated by Agenbag, G, Vorster, A, Julius, S, Ramesar, R, Beighton, P

“…Background. Namaqualand hip dysplasia (NHD) is a mild form of spondyloepiphyseal dysplasia in which progressive arthropathy of the hip joint is a major…”
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Effect of Aspirin or Resistant Starch on Colorectal Neoplasia in the Lynch Syndrome by Burn, John, Bishop, D. Timothy, Mecklin, Jukka-Pekka, Macrae, Finlay, Möslein, Gabriela, Olschwang, Sylviane, Bisgaard, Marie-Luise, Ramesar, Raj, Eccles, Diana, Maher, Eamonn R, Bertario, Lucio, Jarvinen, Heikki J, Lindblom, Annika, Evans, D. Gareth, Lubinski, Jan, Morrison, Patrick J, Ho, Judy W.C, Vasen, Hans F.A, Side, Lucy, Thomas, Huw J.W, Scott, Rodney J, Dunlop, Malcolm, Barker, Gail, Elliott, Faye, Jass, Jeremy R, Fodde, Ricardo, Lynch, Henry T, Mathers, John C

“…This trial tested the influence of aspirin or resistant starch on the incidence of colorectal cancer or colonic adenomas in patients with the Lynch syndrome…”
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South African National Cancer Prevention Services by Goldberg, PA, Muchengeti, M, Buccimazza, I, Malherbe, F, Mbatani, N, van Wyk, A, Ramesar, R

“…The South African National Cancer Prevention Services (SANCaPS) comprises a group with clinical, epidemiological, and oncological skills, established to fill…”
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Identification of a mutation in the ubiquitin-fold modifier 1-specific peptidase 2 gene, UFSP2, in an extended South African family with Beukes hip dysplasia by Watson, Christopher Mark, Crinnion, Laura A, Gleghorn, Lindsay, Newman, William G, Ramesar, Rajkumar, Beighton, Peter, Wallis, Gillian A

“…Beukes hip dysplasia (BHD) is an autosomal dominant disorder of variable penetrance that was originally identified in a large South African family of European…”
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Personality endophenotypes for bipolar affective disorder: a family‐based genetic association analysis by Savitz, J., Van Der Merwe, L., Ramesar, R.

“…Genetic analyses of complex conditions such as bipolar disorder (BD) may be facilitated by the use of intermediate phenotypes. Various personality traits are…”
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A 5-year retrospective analysis of infant death at Salt River Mortuary, Cape Town by Heathfield, L.J, Martin, L.J, Ramesar, R

“…Background. Infant death is a distressing occurrence and unfortunately remains high in many parts of the world, including South Africa (SA). Despite much…”
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Surveillance colonoscopy improves survival in a cohort of subjects with a single mismatch repair gene mutation by Stupart, D. A., Goldberg, P. A., Algar, U., Ramesar, R.

“…Objective  Previous studies have shown a benefit for surveillance colonoscopy in heterogeneous groups of subjects with suspected or proven hereditary…”
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Identification of new cases of early-onset colorectal cancer with an MLH1 epimutation in an ethnically diverse South African cohort by Hitchins, MP, Owens, SE, Kwok, C-T, Godsmark, G, Algar, UF, Ramesar, RS

“…Hitchins MP, Owens SE, Kwok C‐T, Godsmark G, Algar UF, Ramesar RS. Identification of new cases of early‐onset colorectal cancer with an MLH1 epimutation in an…”
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Immunohistochemical determination of mismatch repair gene product in colorectal carcinomas in a young indigenous African cohort by Holla, R, Vorster, A, Locketz, M, de Haas, M, Oke, O.A, Govender, D, Ramesar, R, Goldberg, P.A

“…Background: Colorectal cancer (CRC) in the indigenous African population of South Africa is uncommon (age standardised incidence rates of 11.29 for males and…”
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New-onset diabetes after transplant: Incidence, risk factors and outcome by Ramesar, R., Alagbe, S.C. Alagbe, Swanepoel, C.R., Voster, A.

“…Background. The outcome of renal transplantation depends on achieving effective immunosuppression while minimising the consequences of such treatment. The…”
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G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension by Rayner, B, Ramesar, R, Steyn, K, Levitt, N, Lombard, C, Charlton, K

“…Dopamine via G-protein-coupled receptor kinase 4 (GRK-4) regulates sodium (Na) balance in the proximal tubule of the kidney. Single-nucleotide polymorphisms of…”
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Advancing public health genomics in Africa through prospective cohort studies by Dalal, S, Holmes, M D, Ramesar, R S

“…Human genomic studies have revolutionised science in high-income countries through large cohort studies (on the order of 100,000+ participants) which examine a…”
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Surgery for colonic cancer in HNPCC: total vs segmental colectomy by Stupart, D. A., Goldberg, P. A., Baigrie, R. J., Algar, U., Ramesar, R.

“…Aim  The high reported risk of metachronous colon cancer (MCC) in hereditary nonpolyposis colorectal cancer (HNPCC) has led some authors to recommend total…”
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