Search Results - "RAMEH, L. E"

Phosphoinositide Binding Domains: Embracing 3-Phosphate by Fruman, David A, Rameh, Lucia E, Cantley, Lewis C

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The role of phosphoinositide 3-kinase lipid products in cell function by Rameh, L E, Cantley, L C

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A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate by Rameh, Lucia E, Tolias, Kimberley F, Duckworth, Brian C, Cantley, Lewis C

“…Phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2), a key molecule in the phosphoinositide signalling pathway, was thought to be synthesized exclusively by…”
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A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains by Rameh, Lucia E., Arvidsson, Ann-kristin, Carraway, Kermit L., Couvillon, Anthony D., Rathbun, Gary, Crompton, Anne, VanRenterghem, Barbara, Czech, Michael P., Ravichandran, Kodimangalam S., Burakoff, Steven J., Wang, Da-Sheng, Chen, Ching-Shih, Cantley, Lewis C.

“…Pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains are structurally related regulatory modules that are present in a variety of proteins…”
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Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipids Phosphatidylinositol 3,5-Bisphosphate and Phosphatidylinositol 5-Phosphate by Tolias, K F, Rameh, L E, Ishihara, H, Shibasaki, Y, Chen, J, Prestwich, G D, Cantley, L C, Carpenter, C L

“…Inositol phospholipids regulate a variety of cellular processes including proliferation, survival, vesicular trafficking, and cytoskeletal organization…”
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Regulation of GRP1-catalyzed ADP Ribosylation Factor Guanine Nucleotide Exchange by Phosphatidylinositol 3,4,5-Trisphosphate by Klarlund, Jes K., Rameh, Lucia E., Cantley, Lewis C., Buxton, Joanne M., Holik, John J., Sakelis, Christoper, Patki, Varsha, Corvera, Silvia, Czech, Michael P.

“…Cellular levels of phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) are rapidly elevated in response to activation of growth factor receptor tyrosine…”
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Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity by Volker, J L, Rameh, L E, Zhu, Q, DeCaprio, J, Hansen, U

“…The mammalian transcription factor LSF (CP2/LBP-1c) binds cellular promoters modulated by cell growth signals. We demonstrate here that LSF-DNA-binding…”
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Generation of cell lines to study the role played by oncogenes and anti-oncogenes in cell proliferation control by Costanzi, E, Rameh, L E, Joazeiro, C A, Armelin, M C

“…We report the generation of stable transfectant cell lines by DNA-mediated transfection that overexpress viral and/or cellular oncogenes. Expression of…”
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Downregulation of JE and KC genes by glucocorticoids does not prevent the G0----G1 transition in BALB/3T3 cells by RAMESH, L. E, ARMELIN, M. C. S

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Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins by Rameh, L E, Chen, C S, Cantley, L C

“…Src homology 2 (SH2) domains on the regulatory subunit of phosphoinositide 3-kinase (PI 3-kinase) mediate its binding to specific tyrosine-phosphorylated…”
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AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer by Vasudevan, Krishna M., Barbie, David A., Davies, Michael A., Rabinovsky, Rosalia, McNear, Chontelle J., Kim, Jessica J., Hennessy, Bryan T., Tseng, Hsiuyi, Pochanard, Panisa, Kim, So Young, Dunn, Ian F., Schinzel, Anna C., Sandy, Peter, Hoersch, Sebastian, Sheng, Qing, Gupta, Piyush B., Boehm, Jesse S., Reiling, Jan H., Silver, Serena, Lu, Yiling, Stemke-Hale, Katherine, Dutta, Bhaskar, Joy, Corwin, Sahin, Aysegul A., Gonzalez-Angulo, Ana Maria, Lluch, Ana, Rameh, Lucia E., Jacks, Tyler, Root, David E., Lander, Eric S., Mills, Gordon B., Hahn, William C., Sellers, William R., Garraway, Levi A.

“…Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently in human cancer. PTEN tumor suppressor or PIK3CA oncogene…”
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T antigens' role in polyomavirus transformation: c-myc but not c-fos or c-jun expression is a target for middle T by Rameh, L E, Armelin, M C

“…Polyoma virus (Py) causes neoplastic transformation in vitro and multiple tumors in vivo. The role played by large and middle T antigens (LT, MT) and their…”
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Increased Insulin Sensitivity and Reduced Adiposity in Phosphatidylinositol 5-Phosphate 4-Kinase β−/− Mice by Lamia, Katja A., Peroni, Odile D., Kim, Young-Bum, Rameh, Lucia E., Kahn, Barbara B., Cantley, Lewis C.

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The Phosphatidylinositol (PI)-5-Phosphate 4-Kinase Type II Enzyme Controls Insulin Signaling by Regulating PI-3,4,5-Trisphosphate Degradation by Carricaburu, Valerie, Lamia, Katja A., Lo, Elizabeth, Favereaux, Laetitia, Payrastre, Bernard, Cantley, Lewis C., Rameh, Lucia E.

“…Phosphatidylinositol-5-phosphate (PI-5-P) is a newly identified phosphoinositide with characteristics of a signaling lipid but no known cellular function…”
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Phosphatidylinositol (3,4,5)P 3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins by Rameh, Lucia E., Chen, Ching-Shih, Cantley, Lewis C.

“…Src homology 2 (SH2) domains on the regulatory subunit of phosphoinositide 3-kinase (PI 3-kinase) mediate its binding to specific tyrosine-phosphorylated…”
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Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling by Rameh, Lucia E., Rhee, Sue Goo, Spokes, Katherine, Kazlauskas, Andrius, Cantley, Lewis C., Cantley, Lloyd G.

“…It has been demonstrated that the lipid products of the phosphoinositide 3-kinase (PI3K) can associate with the Src homology 2 (SH2) domains of specific…”
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Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling by Rameh, L E, Rhee, S G, Spokes, K, Kazlauskas, A, Cantley, L C, Cantley, L G

“…It has been demonstrated that the lipid products of the phosphoinositide 3-kinase (PI3K) can associate with the Src homology 2 (SH2) domains of specific…”
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A new pathway for synthesis of phosphatidylinositol-4,6-bisphosphate by RAMEH, L. E, TOLIAS, K. F, DUCKWORTH, B. C, CANTLEY, L. C

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Increased Insulin Sensitivity and Reduced Adiposity in Phosphatidylinositol 5-Phosphate 4-Kinase beta super(-/-) Mice by Lamia, KA, Peroni, O D, Kim, Y-B, Rameh, LE, Kahn, B B, Cantley, L C

“…Phosphorylated derivatives of the lipid phosphatidylinositol are known to play critical roles in insulin response. Phosphatidylinositol 5-phosphate 4- kinases…”
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Identification and Characterization of a Phosphoinositide Phosphate Kinase Homolog by Chang, James D., Field, Seth J., Rameh, Lucia E., Carpenter, Christopher L., Cantley, Lewis C.

“…Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) plays a central role in regulating the actin cytoskeleton as a substrate for phosphoinositide 3-kinase and…”
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