Search Results - "RAMAGE, Judith M"

Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided "immune-hot" colorectal cancers by Talhouni, Shahd, Fadhil, Wakkas, Mongan, Nigel P, Field, Lara, Hunter, Kelly, Makhsous, Sogand, Maciel-Guerra, Alexandre, Kaur, Nayandeep, Nestarenkaite, Ausrine, Laurinavicius, Arvydas, Willcox, Benjamin E, Dottorini, Tania, Spendlove, Ian, Jackson, Andrew M, Ilyas, Mohammad, Ramage, Judith M

“…Characterization of the tumour immune infiltrate (notably CD8+ T-cells) has strong predictive survival value for cancer patients. Quantification of CD8 T-cells…”
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SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade by Xue, Wei, Metheringham, Rachael L., Brentville, Victoria A., Gunn, Barbara, Symonds, Peter, Yagita, Hideo, Ramage, Judith M., Durrant, Lindy G.

“…Checkpoint blockade has demonstrated promising antitumor responses in approximately 10-40% of patients. However, the majority of patients do not make a…”
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Connexin 43 is an independent predictor of patient outcome in breast cancer patients by Chasampalioti, Maria, Green, Andrew R., Ellis, Ian O., Rakha, Emad A., Jackson, Andrew M., Spendlove, Ian, Ramage, Judith M.

“…Purpose Gap junctions are specialized membrane structures that form channels between adjacent cells allowing cell communication. Gap junctions and specifically…”
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Engineering the Human Fc Region Enables Direct Cell Killing by Cancer Glycan-Targeting Antibodies without the Need for Immune Effector Cells or Complement by Vankemmelbeke, Mireille, McIntosh, Richard S, Chua, Jia Xin, Kirk, Thomas, Daniels, Ian, Patsalidou, Marilena, Moss, Robert, Parsons, Tina, Scott, David, Harris, Gemma, Ramage, Judith M, Spendlove, Ian, Durrant, Lindy G

“…Murine IgG3 glycan-targeting mAb often induces direct cell killing in the absence of immune effector cells or complement via a proinflammatory mechanism…”
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CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype by Sutavani, Ruhcha V, Bradley, Richard G, Ramage, Judith M, Jackson, Andrew M, Durrant, Lindy G, Spendlove, Ian

“…Unlike other helper T cells, the costimulatory ligands responsible for T regulatory type 1 (Tr1) cell differentiation remain undefined. Understanding the…”
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Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis by Watson, Nicholas F.S., Ramage, Judith M., Madjd, Zahra, Spendlove, Ian, Ellis, Ian O., Scholefield, John H., Durrant, Lindy G.

“…Many colorectal tumors lose or downregulate cell surface expression of MHC class I molecules conferring resistance to T‐cell‐mediated attack. It has been…”
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Stromal fibroblasts support dendritic cells to maintain IL‐23/Th17 responses after exposure to ionizing radiation by Malecka, Anna, Wang, Qunwei, Shah, Sabaria, Sutavani, Ruhcha V., Spendlove, Ian, Ramage, Judith M., Greensmith, Julie, Franks, Hester A., Gough, Michael J., Saalbach, Anja, Patel, Poulam M., Jackson, Andrew M.

“…Cross talk between DCs and FBs in understanding the effects of IR in DC function. Dendritic cell function is modulated by stromal cells, including fibroblasts…”
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High mobility group protein B1 is a predictor of poor survival in ovarian cancer by Machado, Lee R, Moseley, Paul M, Moss, Robert, Deen, Suha, Nolan, Christopher, Spendlove, Ian, Ramage, Judith M, Chan, Stephen Yt, Durrant, Lindy G

“…High-mobility group protein B1 (HMGB1) has been implicated in numerous tumour types where expression regulates tumour cell growth and survival. We hypothesised…”
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DNA vaccination with T-cell epitopes encoded within Ab molecules induces high-avidity anti-tumor CD8⁺ T cells by Pudney, Victoria A, Metheringham, Rachael L, Gunn, Barbara, Spendlove, Ian, Ramage, Judith M, Durrant, Lindy G

“…Stimulation of high-avidity CTL responses is essential for effective anti-tumor and anti-viral vaccines. In this study we have demonstrated that a DNA vaccine…”
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Complement decay accelerating factor (DAF)/CD55 in cancer by SPENDLOVE, Ian, RAMAGE, Judith M, BRADLEY, Richard, HARRIS, Claire, DURRANT, Lindy G

“…The complement system is a powerful innate mechanism involved in protection of the host against pathogens. It also has a role in the clearance of apoptotic…”
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T Cell Responses to Heat-Shock Protein 60: Differential Responses by CD4+ T Cell Subsets According to Their Expression of CD45 Isotypes by Ramage, Judith M, Young, Joyce L, Goodall, Jane C, Hill Gaston, J. S

“…We demonstrate that human T lymphocytes proliferate in vitro to highly purified human heat-shock protein 60 (Hu.hsp60). The response to this self Ag was…”
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Identification of an HLA‐A0201 cytotoxic T lymphocyte epitope specific to the endothelial antigen Tie‐2 by Ramage, Judith M., Metheringham, Rachael, Conn, Andrew, Spendlove, Ian, Moss, Robert S., Patton, Daniel T., Murray, J. Clifford, Rees, Robert C., Durrant, Lindy G.

“…Tie‐2 stabilises pericyte–endothelial interactions during angiogenesis and is highly expressed on endothelium during several diseases, including arthritis,…”
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Comparison of the immune response to a self antigen after DNA immunisation of HLAA201/H-2Kb and HHD transgenic mice by Ramage, Judith M., Metheringham, Rachael, Moss, Robert, Spendlove, Ian, Rees, Robert, Durrant, Lindy G.

“…HHD mice which express human HLA-A2 but no mouse class I, have been shown to have improved cytotoxic lymphocyte (CTL) responses to foreign antigens compared to…”
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The use of reverse immunology to identify HLA-A2 binding epitopes in Tie-2 by RAMAGE, Judith M, SPENDLOVE, Ian, REES, Robert, MOSS, Robert S, DURRANT, Lindy G

“…A potential target for a cancer vaccine would be receptors, such as Tie-2 which are over expressed on tumour endothelium. Using computer aided motif…”
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Comparison of the immune response to a self antigen after DNA immunisation of HLAA201/H-2KB and HHD transgenic mice: DNA vaccines: research frontiers and clinical applications by RAMAGE, Judith M, METHERINGHAM, Rachael, MOSS, Robert, SPENDLOVE, Ian, REES, Robert, DURRANT, Lindy G

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In vitro responses of human CD45R0brightRA- and CD45R0-RAbright T cell subsets and their relationship to memory and naive T cells by Young, J L, Ramage, J M, Gaston, J S, Beverley, P C

“…The cellular basis of immunological memory, particularly with respect to T cells is not understood. In humans, monoclonal antibodies to CD45 have been used to…”
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Lymphoctes: A Practical Approach (2nd edn) by Ramage, Judith M

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Lymphoctes: A Practical Approach (2nd edn): Edited by S.L. Rowland-Jones and A.J. McMichael, Oxford University Press, 2000. £32.50(xxiii+352 pages) ISBN 0 19 963816 0 by Ramage, Judith M

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