Search Results - "RALPH, R"

Antibiotic modulation of capsular exopolysaccharide and virulence in Acinetobacter baumannii by Geisinger, Edward, Isberg, Ralph R

“…Acinetobacter baumannii is an opportunistic pathogen of increasing importance due to its propensity for intractable multidrug-resistant infections in…”
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Radiotherapy and immunotherapy: a beneficial liaison? by Weichselbaum, Ralph R., Liang, Hua, Deng, Liufu, Fu, Yang-Xin

“…Key Points Radiotherapy not only exerts direct cytotoxic effects on tumour cells, but also re-programmes the tumour microenvironment to exert a potent…”
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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors by Deng, Liufu, Liang, Hua, Xu, Meng, Yang, Xuanming, Burnette, Byron, Arina, Ainhoa, Li, Xiao-Dong, Mauceri, Helena, Beckett, Michael, Darga, Thomas, Huang, Xiaona, Gajewski, Thomas F., Chen, Zhijian J., Fu, Yang-Xin, Weichselbaum, Ralph R.

“…Ionizing radiation-mediated tumor regression depends on type I interferon (IFN) and the adaptive immune response, but several pathways control I IFN induction…”
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Photodynamic Therapy Mediated by Nontoxic Core–Shell Nanoparticles Synergizes with Immune Checkpoint Blockade To Elicit Antitumor Immunity and Antimetastatic Effect on Breast Cancer by Duan, Xiaopin, Chan, Christina, Guo, Nining, Han, Wenbo, Weichselbaum, Ralph R, Lin, Wenbin

“…An effective, nontoxic, tumor-specific immunotherapy is the ultimate goal in the battle against cancer, especially the metastatic disease. Checkpoint…”
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Interplay Between Antibiotic Resistance and Virulence During Disease Promoted by Multidrug-Resistant Bacteria by Geisinger, Edward, Isberg, Ralph R.

“…Diseases caused by antibiotic-resistant bacteria in hospitals are the outcome of complex relationships between several dynamic factors, including bacterial…”
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Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy by He, Chunbai, Duan, Xiaopin, Guo, Nining, Chan, Christina, Poon, Christopher, Weichselbaum, Ralph R., Lin, Wenbin

“…Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate of only 12% for patients with the metastatic disease. Checkpoint…”
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Radiotherapy and Immunotherapy for Cancer: From "Systemic" to "Multisite" by Arina, Ainhoa, Gutiontov, Stanley I, Weichselbaum, Ralph R

“…In the era of cancer immunotherapy, there is significant interest in combining conventional cancer therapies, such as radiotherapy, with drugs that stimulate…”
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Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice by Deng, Liufu, Liang, Hua, Burnette, Byron, Beckett, Michael, Darga, Thomas, Weichselbaum, Ralph R, Fu, Yang-Xin

“…High-dose ionizing irradiation (IR) results in direct tumor cell death and augments tumor-specific immunity, which enhances tumor control both locally and…”
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The 46th David A. Karnofsky Memorial Award Lecture: Oligometastasis-From Conception to Treatment by Weichselbaum, Ralph R

“…Metastasis from most adult solid tumors generally has been considered to be widespread and incurable. Here, I present clinical and molecular data to support…”
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Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors by Duan, Xiaopin, Chan, Christina, Han, Wenbo, Guo, Nining, Weichselbaum, Ralph R., Lin, Wenbin

“…Nanoparticles can potentially stimulate tumour microenvironments to elicit antitumour immunity. Herein, we demonstrate effective immunotherapy of colorectal…”
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Nanoparticle‐Mediated Radiotherapy Remodels the Tumor Microenvironment to Enhance Antitumor Efficacy by Zhen, Wenyao, Weichselbaum, Ralph R., Lin, Wenbin

“…Radiotherapy (RT) uses ionizing radiation to eradicate localized tumors and, in rare cases, control tumors outside of the irradiated fields via stimulating an…”
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Failures of memory and the fate of forgotten memories by Miller, Ralph R.

“…•Seemingly different memory failures often reduce to poor retrieval cues & associative interference.•Forgetting arises from an active, inhibitory, reversible…”
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Chlorin-Based Nanoscale Metal–Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy by Lu, Kuangda, He, Chunbai, Guo, Nining, Chan, Christina, Ni, Kaiyuan, Weichselbaum, Ralph R, Lin, Wenbin

“…Photodynamic therapy (PDT) can destroy local tumors and minimize normal tissue damage, but is ineffective at eliminating metastases. Checkpoint blockade…”
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Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation by Mitchell, Gabriel, Isberg, Ralph R.

“…Recent excitement regarding immune clearance of intracellular microorganisms has focused on two systems that maintain cellular homeostasis. One system includes…”
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Integration of radiotherapy and immunotherapy for treatment of oligometastases by Pitroda, Sean P, MD, Chmura, Steven J, MD, Weichselbaum, Ralph R, Prof

“…SummaryMetastasis is the leading cause of cancer-related mortality and remains one of the prevailing challenges in cancer treatment. Most patients with…”
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Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling by Shi, Yaoyao, Zheng, Wenxin, Yang, Kaiting, Harris, Katharine G, Ni, Kaiyuan, Xue, Lai, Lin, Wenbin, Chang, Eugene B, Weichselbaum, Ralph R, Fu, Yang-Xin

“…Most studies focus on how intestinal microbiota influence cancer immunotherapy through activating gut immunity. However, immunotherapies related to innate…”
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Host STING-dependent MDSC mobilization drives extrinsic radiation resistance by Liang, Hua, Deng, Liufu, Hou, Yuzhu, Meng, Xiangjiao, Huang, Xiaona, Rao, Enyu, Zheng, Wenxin, Mauceri, Helena, Mack, Matthias, Xu, Meng, Fu, Yang-Xin, Weichselbaum, Ralph R.

“…Radiotherapy induces and promotes innate and adaptive immunity in which host STING plays an important role. However, radioresistance in irradiated tumors can…”
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Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy by Ni, Kaiyuan, Lan, Guangxu, Chan, Christina, Quigley, Bryan, Lu, Kuangda, Aung, Theint, Guo, Nining, La Riviere, Patrick, Weichselbaum, Ralph R., Lin, Wenbin

“…Checkpoint blockade immunotherapy enhances systemic antitumor immune response by targeting T cell inhibitory pathways; however, inadequate T cell infiltration…”
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Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade by Si, Wei, Liang, Hua, Bugno, Jason, Xu, Qi, Ding, Xingchen, Yang, Kaiting, Fu, Yanbin, Weichselbaum, Ralph R, Zhao, Xin, Wang, Liangliang

“…Our goals were to evaluate the antitumour efficacy of GG (LGG) in combination with immune checkpoint blockade (ICB) immunotherapies on tumour growth and to…”
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PCT: Point cloud transformer by Guo, Meng-Hao, Cai, Jun-Xiong, Liu, Zheng-Ning, Mu, Tai-Jiang, Martin, Ralph R., Hu, Shi-Min

“…The irregular domain and lack of ordering make it challenging to design deep neural networks for point cloud processing. This paper presents a novel framework…”
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