Search Results - "RAKOCZY, P. E"

Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: a long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity by MARANO, R. J, TOTH, I, WIMMER, N, BRANKOV, M, RAKOCZV, P. E

“…We have performed a long-term study into the use of a lipophilic amino-acid dendrimer to deliver an anti-vascular endothelial growth factor (VEGF)…”
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Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates by Lai, C-M, Estcourt, M J, Himbeck, R P, Lee, S-Y, Yew-San Yeo, I, Luu, C, Loh, B K, Lee, M W, Barathi, A, Villano, J, Ang, C-L, van der Most, R G, Constable, I J, Dismuke, D, Samulski, R J, Degli-Esposti, M A, Rakoczy, E P

“…We report on the long-term safety of AAV2.sFlt-1 (a recombinant adeno-associated virus serotype 2 carrying the soluble form of the Flt-1 receptor) injection…”
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Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapy by LAI, Y. K. Y, SHEN, W. Y, BRANKOV, M, LAI, C. M, CONSTABLE, I. T, RAKOCZY, P. E

“…Neovascularisation (NV) within the eye often results in visual loss. Vascular endothelial growth factor (VEGF) has been implicated in the development of ocular…”
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Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model by SHEN, W.-Y, LAI, C. M, GRAHAM, C. E, BINZ, N, LAI, Y. K. Y, EADE, J, GUIDOLIN, D, RIBATTI, D, DUNLOP, S. A, RAKOCZY, P. E

“…Vascular endothelial growth factor (VEGF) plays a pivotal role in the pathogenesis of diabetic retinopathy. We investigated whether transgenic mice with…”
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Overexpression of Vascular Endothelial Growth Factor (VEGF) in the Retinal Pigment Epithelium Leads to the Development of Choroidal Neovascularization by Spilsbury, Katrina, Garrett, Kerryn L., Shen, Wei-Yong, Constable, Ian J., Rakoczy, Piroska E.

“…Vascular endothelial growth factor (VEGF) has been strongly implicated in the development of choroidal neovascularization found in age-related macular…”
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Generation of transgenic mice with mild and severe retinal neovascularisation by Lai, C-M, Dunlop, S A, May, L A, Gorbatov, M, Brankov, M, Shen, W-Y, Binz, N, Lai, Y KY, Graham, C E, Barry, C J, Constable, I J, Beazley, L D, Rakoczy, E P

“…Aim: To generate a mouse model for slow progressive retinal neovascularisation through vascular endothelial growth factor (VEGF) upregulation. Methods:…”
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VEGF-induced choroidal damage in a murine model of retinal neovascularisation by Tee, L B G, Penrose, M A, O'Shea, J E, Lai, C-M, Rakoczy, E P, Dunlop, S A

“…Photoreceptor-specific upregulation of vascular endothelial growth factor (VEGF) in a transgenic mouse model (Kimba) of retinal neovascularisation induces…”
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Expression of cell adhesion molecules and vascular endothelial growth factor in experimental choroidal neovascularisation in the rat by Shen, W Y, Yu, M J T, Barry, C J, Constable, I J, Rakoczy, P E

“…AIMS To investigate the longevity and reproducibility of choroidal neovascularisation (CNV) induced by krypton laser photocoagulation in the rat. The presence…”
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Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization by Lai, C M, Brankov, M, Zaknich, T, Lai, Y K, Shen, W Y, Constable, I J, Kovesdi, I, Rakoczy, P E

“…Pathological angiogenesis, or the production of new capillary vessels from preexisting vasculature, within the eye is a serious event that often leads to…”
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Eph/ephrin expression in the adult rat visual system following localized retinal lesions: localized and transneuronal up-regulation in the retina and superior colliculus by Rodger, J., Symonds, A. C. E., Springbett, J., Shen, W-Y., Bartlett, C. A., Rakoczy, P. E., Beazley, L. D., Dunlop, S. A.

“…Following unilateral optic nerve section in adult PVG hooded rat, the axon guidance cue ephrin‐A2 is up‐regulated in caudal but not rostral superior colliculus…”
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Lipofuscin of the retinal pigment epithelium: A review by KENNEDY, C. J, RAKOCZY, P. E, CONSTABLE, I. J

“…Accumulation of lipofuscin is one of the most characteristic features of ageing observed in retinal pigment epithelial (RPE) cells. The lipofuscin found in RPE…”
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Entrainment of circadian rhythm to a photoperiod reversal shows retinal dystrophy in RPE65 −/− mice by Daniels, D.M, Stoddart, C.W, Martin-Iverson, M.T, Lai, C.-M, Redmond, T.M, Rakoczy, P.E

“…Light entrainment of circadian rhythms is mediated by classical “visual” photoreceptors (rods and cones) as well as “nonvisual” photoreceptive elements…”
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Differentiation of Marrow Stromal Cells into Photoreceptors in the Rat Eye by Kicic, Anthony, Shen, Wei-Yong, Wilson, Ann S, Constable, Ian J, Robertson, Terry, Rakoczy, P. Elizabeth

“…Retinal degenerations and dystrophies are the major causes of genetically inherited blindness that are characterized by the apoptotic death of the…”
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Detection and possible functions of a cysteine protease involved in digestion of rod outer segments by retinal pigment epithelial cells by Rakoczy, PE, Mann, K, Cavaney, DM, Robertson, T, Papadimitreou, J, Constable, IJ

“…To investigate the presence and role of a recently cloned cysteine protease (cathepsin S) in the digestion of rod outer segments (ROS) by cultured retinal…”
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An improved method using densitometry for evaluating severity of laser photocoagulation induced CNV by Marano, R J, Rakoczy, P E

“…Laser photocoagulation induced choroidal neovascularization currently is the most effective model available for the study of this disease in terms of efficacy…”
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Distribution of Cathepsin D in Human Eyes with or without Age-related Maculopathy by RAKOCZY, PIROSKA E., SARKS, SHIRLEY H., DAW, NATALIE, CONSTABLE, IAN J.

“…Cathepsin D is a ubiquitous enzyme which plays an important role in the catabolism of proteins. Enzymatic studies showed that cathepsin D is the most important…”
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Kinetic studies on phagocytosis and lysosomal digestion of rod outer segments by human retinal pigment epithelial cells in vitro by Kennedy, C J, Rakoczy, P E, Robertson, T A, Papadimitriou, J M, Constable, I J

“…Using novel methodology, this study describes the kinetics of rod outer segment (ROS) phagocytosis and digestion by human retinal pigment epithelial (RPE)…”
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Inhibition of diclofenac formulated in hyaluronan on angiogenesis in vitro and its intraocular tolerance in the rabbit eye by Shen, W Y, Constable, I J, Chelva, E, Rakoczy, P E

“…To investigate the effect of diclofenac, a potent nonsteroidal anti-inflammatory drug, formulated in hyaluronan (diclofenac/HA) on angiogenesis in vitro and…”
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The Use of Adenovirus-Mediated Gene Transfer to Develop a Rat Model for Photoreceptor Degeneration by Lai, Chooi-May, Shen, Wei-Yong, Constable, Ian, Rakoczy, Piroska Elizabeth

“…To investigate the effects of recombinant adenovirus-mediated downregulation of cathepsin S (CatS) on the retinal pigment epithelium and/or neural retina in…”
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Expression of cathepsin S antisense transcripts by adenovirus in retinal pigment epithelial cells by Rakoczy, PE, Lai, MC, Baines, MG, Spilsbury, K, Constable, IJ

“…To show the production of sense or antisense transcripts by recombinant adenoviruses, to investigate whether the transcripts produced were suitable for…”
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