Search Results - "RAKHEJA, Dinesh"

Viable and necrotic tumor assessment from whole slide images of osteosarcoma using machine-learning and deep-learning models by Arunachalam, Harish Babu, Mishra, Rashika, Daescu, Ovidiu, Cederberg, Kevin, Rakheja, Dinesh, Sengupta, Anita, Leonard, David, Hallac, Rami, Leavey, Patrick

“…Pathological estimation of tumor necrosis after chemotherapy is essential for patients with osteosarcoma. This study reports the first fully automated tool to…”
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SARS-CoV-2-related Hypercoagulable State Leading to Ischemic Enteritis Secondary to Superior Mesenteric Artery Thrombosis by Mitchell, James Michael, Rakheja, Dinesh, Gopal, Purva

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Basic Histopathologic Assessment of Germ Cell Tumors for Clinic and Research by Kapur, Payal, Rakheja, Dinesh

“…This chapter introduces the macroscopic and light microscopic features of testicular germ cell tumors (GCT) commonly encountered in clinical practice. Accurate…”
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Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney by Kapur, Payal, Gao, Ming, Zhong, Hua, Chintalapati, Suneetha, Mitui, Midori, Barnes, Spencer D., Zhou, Qinbo, Miyata, Jeffrey, Carrillo, Deyssy, Malladi, Venkat S., Rakheja, Dinesh, Pedrosa, Ivan, Xu, Lin, Kinch, Lisa, Brugarolas, James

“…Low-grade oncocytic tumor (LOT) of the kidney is a recently described entity with poorly understood pathogenesis. Using next-generation sequencing (NGS) and…”
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Oncometabolites: A New Paradigm for Oncology, Metabolism, and the Clinical Laboratory by Collins, Rebecca R J, Patel, Khushbu, Putnam, William C, Kapur, Payal, Rakheja, Dinesh

“…Pediatric clinical laboratories commonly measure tricarboxylic acid cycle intermediates for screening, diagnosis, and monitoring of specific inborn errors of…”
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Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups by Sumazin, Pavel, Chen, Yidong, Treviño, Lisa R., Sarabia, Stephen F., Hampton, Oliver A., Patel, Kayuri, Mistretta, Toni‐Ann, Zorman, Barry, Thompson, Patrick, Heczey, Andras, Comerford, Sarah, Wheeler, David A., Chintagumpala, Murali, Meyers, Rebecka, Rakheja, Dinesh, Finegold, Milton J., Tomlinson, Gail, Parsons, D. Williams, López‐Terrada, Dolores

“…Despite being the most common liver cancer in children, hepatoblastoma (HB) is a rare neoplasm. Consequently, few pretreatment tumors have been molecularly…”
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p53 genes function to restrain mobile elements by Wylie, Annika, Jones, Amanda E, D'Brot, Alejandro, Lu, Wan-Jin, Kurtz, Paula, Moran, John V, Rakheja, Dinesh, Chen, Kenneth S, Hammer, Robert E, Comerford, Sarah A, Amatruda, James F, Abrams, John M

“…Throughout the animal kingdom, p53 genes govern stress response networks by specifying adaptive transcriptional responses. The human member of this gene family…”
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Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects by Mullen, Andrew R., Hu, Zeping, Shi, Xiaolei, Jiang, Lei, Boroughs, Lindsey K., Kovacs, Zoltan, Boriack, Richard, Rakheja, Dinesh, Sullivan, Lucas B., Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.

“…Mammalian cells generate citrate by decarboxylating pyruvate in the mitochondria to supply the tricarboxylic acid (TCA) cycle. In contrast, hypoxia and other…”
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Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models by Nguyen, Liem H., Robinton, Daisy A., Seligson, Marc T., Wu, Linwei, Li, Lin, Rakheja, Dinesh, Comerford, Sarah A., Ramezani, Saleh, Sun, Xiankai, Parikh, Monisha S., Yang, Erin H., Powers, John T., Shinoda, Gen, Shah, Samar P., Hammer, Robert E., Daley, George Q., Zhu, Hao

“…Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and oncogenesis. Poorly differentiated, aggressive cancers often…”
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Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma by Shenoy, Niraj, Bhagat, Tushar D, Cheville, John, Lohse, Christine, Bhattacharyya, Sanchari, Tischer, Alexander, Machha, Venkata, Gordon-Mitchell, Shanisha, Choudhary, Gaurav, Wong, Li-Fan, Gross, LouAnn, Ressigue, Emily, Leibovich, Bradley, Boorjian, Stephen A, Steidl, Ulrich, Wu, Xiaosheng, Pradhan, Kith, Gartrell, Benjamin, Agarwal, Beamon, Pagliaro, Lance, Suzuki, Masako, Greally, John M, Rakheja, Dinesh, Thompson, R Houston, Susztak, Katalin, Witzig, Thomas, Zou, Yiyu, Verma, Amit

“…Although clear cell renal cell carcinoma (ccRCC) has been shown to result in widespread aberrant cytosine methylation and loss of 5-hydroxymethylcytosine…”
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L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer by Shim, Eun-Hee, Livi, Carolina B, Rakheja, Dinesh, Tan, Jubilee, Benson, Daniel, Parekh, Vishwas, Kho, Eun-Young, Ghosh, Arindam P, Kirkman, Richard, Velu, Sadanan, Dutta, Shilpa, Chenna, Balachandra, Rea, Shane L, Mishur, Robert J, Li, Qiuhua, Johnson-Pais, Teresa L, Guo, Lining, Bae, Sejong, Wei, Shi, Block, Karen, Sudarshan, Sunil

“…Through unbiased metabolomics, we identified elevations of the metabolite 2-hydroxyglutarate (2HG) in renal cell carcinoma (RCC). 2HG can inhibit…”
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Spindle Cell/Sclerosing Rhabdomyosarcoma With PAX8::PPARG Fusion by Rakheja, Dinesh, Park, Jason Y., Alhasan, Mustafa, Uddin, Naseem

“…The spindle cell/sclerosing subtype of rhabdomyosarcoma is classified based on genetic features into the three categories of MYOD1-mutated, gene fusion-driven,…”
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Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes by Heaphy, Christopher M, Subhawong, Andrea P, Hong, Seung-Mo, Goggins, Michael G, Montgomery, Elizabeth A, Gabrielson, Edward, Netto, George J, Epstein, Jonathan I, Lotan, Tamara L, Westra, William H, Shih, Ie-Ming, Iacobuzio-Donahue, Christine A, Maitra, Anirban, Li, Qing K, Eberhart, Charles G, Taube, Janis M, Rakheja, Dinesh, Kurman, Robert J, Wu, T.C, Roden, Richard B, Argani, Pedram, De Marzo, Angelo M, Terracciano, Luigi, Torbenson, Michael, Meeker, Alan K

“…Approximately 10% to 15% of human cancers lack detectable telomerase activity, and a subset of these maintain telomere lengths by the telomerase-independent…”
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Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis by Wang, Shan-Shan, Gu, Yi-Feng, Wolff, Nicholas, Stefanius, Karoliina, Christie, Alana, Dey, Anwesha, Hammer, Robert E., Xie, Xian-Jin, Rakheja, Dinesh, Pedrosa, Ivan, Carroll, Thomas, McKay, Renée M., Kapur, Payal, Brugarolas, James

“…Why different species are predisposed to different tumor spectra is not well understood. In particular, whether the physical location of tumor suppressor genes…”
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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors by Carugo, Alessandro, Minelli, Rosalba, Sapio, Luigi, Soeung, Melinda, Carbone, Federica, Robinson, Frederick S., Tepper, James, Chen, Ziheng, Lovisa, Sara, Svelto, Maria, Amin, Samirkumar, Srinivasan, Sanjana, Del Poggetto, Edoardo, Loponte, Sara, Puca, Francesca, Dey, Prasenjit, Malouf, Gabriel G., Su, Xiaoping, Li, Liren, Lopez-Terrada, Dolores, Rakheja, Dinesh, Lazar, Alexander J., Netto, George J., Rao, Priya, Sgambato, Alessandro, Maitra, Anirban, Tripathi, Durga N., Walker, Cheryl L., Karam, Jose A., Heffernan, Timothy P., Viale, Andrea, Roberts, Charles W.M., Msaouel, Pavlos, Tannir, Nizar M., Draetta, Giulio F., Genovese, Giannicola

“…Alterations in chromatin remodeling genes have been increasingly implicated in human oncogenesis. Specifically, the biallelic inactivation of the SWI/SNF…”
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DICER1-associated central nervous system sarcoma in children: comprehensive clinicopathologic and genetic analysis of a newly described rare tumor by Kamihara, Junne, Paulson, Vera, Breen, Micheál A., Laetsch, Theodore W., Rakheja, Dinesh, Shulman, David S., Schoettler, Michelle L., Clinton, Catherine M., Ward, Abigail, Reidy, Deirdre, Pinches, R. Seth, Weiser, Daniel A., Mullen, Elizabeth A., Schienda, Jaclyn, Meyers, Paul A., DuBois, Steven G., Nowak, Jonathan A., Foulkes, William D., Schultz, Kris Ann P., Janeway, Katherine A., Vargas, Sara O., Church, Alanna J.

“…The spectrum of neoplasms associated with DICER1 variants continues to expand, with the recent addition of primary “ DICER1 -associated central nervous system…”
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PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis by Kendall, Genevieve C, Watson, Sarah, Xu, Lin, LaVigne, Collette A, Murchison, Whitney, Rakheja, Dinesh, Skapek, Stephen X, Tirode, Franck, Delattre, Olivier, Amatruda, James F

“…Alveolar rhabdomyosarcoma is a pediatric soft-tissue sarcoma caused by fusion oncogenes and is characterized by impaired skeletal muscle development. We…”
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IDH mutations in acute myeloid leukemia by Rakheja, Dinesh, MD, Konoplev, Sergej, MD, Medeiros, L. Jeffrey, MD, Chen, Weina, MD, PhD

“…Summary Acute myeloid leukemia is a heterogeneous group of diseases. Mutations of the isocitrate dehydrogenase ( IDH) genes represent a novel class of point…”
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Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney by Roy, Angshumoy, Kumar, Vijetha, Zorman, Barry, Fang, Erica, Haines, Katherine M., Doddapaneni, HarshaVardhan, Hampton, Oliver A., White, Simon, Bavle, Abhishek A., Patel, Nimesh R., Eldin, Karen W., John Hicks, M., Rakheja, Dinesh, Leavey, Patrick J., Skapek, Stephen X., Amatruda, James F., Nuchtern, Jed G., Chintagumpala, Murali M., Wheeler, David A., Plon, Sharon E., Sumazin, Pavel, Parsons, D. Williams

“…The X-linked BCL-6 co-repressor ( BCOR ) gene encodes a key constituent of a variant polycomb repressive complex (PRC) that is mutated or translocated in human…”
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MYC, mitochondrial metabolism and O-GlcNAcylation converge to modulate the activity and subcellular localization of DNA and RNA demethylases by Lin, An-Ping, Qiu, Zhijun, Ethiraj, Purushoth, Sasi, Binu, Jaafar, Carine, Rakheja, Dinesh, Aguiar, Ricardo C. T.

“…Mitochondria can function as signaling organelles, and part of this output leads to epigenetic remodeling. The full extent of this far-reaching interplay…”
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