Search Results - "RAKHA, Emad A"

New Advances in Molecular Breast Cancer Pathology by Rakha, Emad A., Pareja, Fresia G.

“…Breast cancer (BC) comprises a diverse spectrum of diseases featuring distinct presentation, morphological, biological, and clinical phenotypes. BC behaviour…”
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A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal by Rindi, Guido, Klimstra, David S., Abedi-Ardekani, Behnoush, Asa, Sylvia L., Bosman, Frederik T., Brambilla, Elisabeth, Busam, Klaus J., de Krijger, Ronald R., Dietel, Manfred, El-Naggar, Adel K., Fernandez-Cuesta, Lynnette, Klöppel, Günter, McCluggage, W. Glenn, Moch, Holger, Ohgaki, Hiroko, Rakha, Emad A., Reed, Nicholas S., Rous, Brian A., Sasano, Hironobu, Scarpa, Aldo, Scoazec, Jean-Yves, Travis, William D., Tallini, Giovanni, Trouillas, Jacqueline, van Krieken, J. Han, Cree, Ian A.

“…The classification of neuroendocrine neoplasms (NENs) differs between organ systems and currently causes considerable confusion. A uniform classification…”
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The role of glutaminase in cancer by Masisi, Brendah K, El Ansari, Rokaya, Alfarsi, Lutfi, Rakha, Emad A, Green, Andrew R, Craze, Madeleine L

“…Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key metabolic change in cancer cells. Breast cancer is a…”
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Artificial intelligence in digital breast pathology: Techniques and applications by Ibrahim, Asmaa, Gamble, Paul, Jaroensri, Ronnachai, Abdelsamea, Mohammed M., Mermel, Craig H., Chen, Po-Hsuan Cameron, Rakha, Emad A.

“…Breast cancer is the most common cancer and second leading cause of cancer-related death worldwide. The mainstay of breast cancer workup is histopathological…”
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Basal-Like Breast Cancer: A Critical Review by RAKHA, Emad A, REIS-FILHO, Jorge S, ELLIS, Ian O

“…Recent gene expression profiling of breast cancer has identified specific subtypes with clinical, biologic, and therapeutic implications. The basal-like group…”
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Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival by Joseph, Chitra, Alsaleem, Mansour, Orah, Nnamdi, Narasimha, Pavan L., Miligy, Islam M., Kurozumi, Sasagu, Ellis, Ian O., Mongan, Nigel P., Green, Andrew R., Rakha, Emad A.

“…Purpose MMP9 is a matricellular protein associated with extracellular matrix (ECM) remodelling, that promotes tumour progression, and modulates the activity of…”
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The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours by El Ansari, Rokaya, Craze, Madeleine L, Miligy, Islam, Diez-Rodriguez, Maria, Nolan, Christopher C, Ellis, Ian O, Rakha, Emad A, Green, Andrew R

“…Breast cancer (BC) is a heterogeneous disease characterised by variant biology and patient outcome. The amino acid transporter, SLC7A5, plays a role in BC…”
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Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery by Shipp, Dustin W, Rakha, Emad A, Koloydenko, Alexey A, Macmillan, R Douglas, Ellis, Ian O, Notingher, Ioan

“…In over 20% of breast conserving operations, postoperative pathological assessment of the excised tissue reveals positive margins, requiring additional…”
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Potential quality pitfalls of digitalized whole slide image of breast pathology in routine practice by Atallah, Nehal M., Toss, Michael S., Verrill, Clare, Salto-Tellez, Manuel, Snead, David, Rakha, Emad A.

“…Using digitalized whole slide images (WSI) in routine histopathology practice is a revolutionary technology. This study aims to assess the clinical impacts of…”
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Atypical ductal hyperplasia: update on diagnosis, management, and molecular landscape by Kader, Tanjina, Hill, Prue, Rakha, Emad A, Campbell, Ian G, Gorringe, Kylie L

“…Atypical ductal hyperplasia (ADH) is a common diagnosis in the mammographic era and a significant clinical problem with wide variation in diagnosis and…”
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Enhanced glutamine uptake influences composition of immune cell infiltrates in breast cancer by Ansari, Rokaya El, Craze, Madeleine L., Althobiti, Maryam, Alfarsi, Lutfi, Ellis, Ian O., Rakha, Emad A., Green, Andrew R.

“…Background Cancer cells must alter their metabolism to support proliferation. Immune evasion also plays a role in supporting tumour progression. This study…”
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A whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk by Klimov, Sergey, Miligy, Islam M, Gertych, Arkadiusz, Jiang, Yi, Toss, Michael S, Rida, Padmashree, Ellis, Ian O, Green, Andrew, Krishnamurti, Uma, Rakha, Emad A, Aneja, Ritu

“…Breast ductal carcinoma in situ (DCIS) represent approximately 20% of screen-detected breast cancers. The overall risk for DCIS patients treated with…”
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Updated UK Recommendations for HER2 assessment in breast cancer by Rakha, Emad A, Pinder, Sarah E, Bartlett, John M S, Ibrahim, Merdol, Starczynski, Jane, Carder, Pauline J, Provenzano, Elena, Hanby, Andrew, Hales, Sally, Lee, Andrew H S, Ellis, Ian O

“…Human epidermal growth factor receptor 2 (HER2) overexpression is present in approximately 15% of early invasive breast cancers, and is an important predictive…”
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Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas by Geyer, Felipe C., Li, Anqi, Papanastasiou, Anastasios D., Smith, Alison, Selenica, Pier, Burke, Kathleen A., Edelweiss, Marcia, Wen, Huei-Chi, Piscuoglio, Salvatore, Schultheis, Anne M., Martelotto, Luciano G., Pareja, Fresia, Kumar, Rahul, Brandes, Alissa, Fan, Dan, Basili, Thais, Da Cruz Paula, Arnaud, Lozada, John R., Blecua, Pedro, Muenst, Simone, Jungbluth, Achim A., Foschini, Maria P., Wen, Hannah Y., Brogi, Edi, Palazzo, Juan, Rubin, Brian P., Ng, Charlotte K. Y., Norton, Larry, Varga, Zsuzsanna, Ellis, Ian O., Rakha, Emad A., Chandarlapaty, Sarat, Weigelt, Britta, Reis-Filho, Jorge S.

“…Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial−myoepithelial differentiation, whose genetic underpinning is largely unknown…”
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Prognostic markers in triple‐negative breast cancer by Rakha, Emad A., El‐Sayed, Maysa E., Green, Andrew R., Lee, Andrew H. S., Robertson, John F., Ellis, Ian O.

“…BACKGROUND. Triple‐negative breast cancer (estrogen receptor‐negative, progesterone receptor‐negative, and HER2‐negative) is a high risk breast cancer that…”
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Prognostic Significance of Nottingham Histologic Grade in Invasive Breast Carcinoma by RAKHA, Emad A, EL-SAYED, Maysa E, LEE, Andrew H. S, ELSTON, Christopher W, GRAINGE, Matthew J. J, HODI, Zsolt, BLAMEY, Roger W, ELLIS, Ian O

“…The three strongest prognostic determinants in operable breast cancer used in routine clinical practice are lymph node (LN) stage, primary tumor size, and…”
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Prognostic significance of androgen receptor expression in invasive breast cancer: transcriptomic and protein expression analysis by Aleskandarany, Mohammad A., Abduljabbar, Rezvan, Ashankyty, Ibraheem, Elmouna, Ahmed, Jerjees, Dena, Ali, Simak, Buluwela, Laki, Diez-Rodriguez, Maria, Caldas, Carlos, Green, Andrew R., Ellis, Ian O., Rakha, Emad A.

“…Differential prognostic roles of Androgen Receptor (AR) have been proposed in breast cancer (BC) depending on tumour oestrogen receptor (ER) status. This study…”
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The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative breast cancer subtypes by El Ansari, Rokaya, Craze, Madeleine L., Diez-Rodriguez, Maria, Nolan, Christopher C., Ellis, Ian O., Rakha, Emad A., Green, Andrew R.

“…Breast cancer (BC) is a heterogeneous disease characterised by variant biology, metabolic activity and patient outcome. This study aimed to evaluate the…”
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Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors by Pareja, Fresia, Brandes, Alissa H., Basili, Thais, Selenica, Pier, Geyer, Felipe C., Fan, Dan, Da Cruz Paula, Arnaud, Kumar, Rahul, Brown, David N., Gularte-Mérida, Rodrigo, Alemar, Barbara, Bi, Rui, Lim, Raymond S., de Bruijn, Ino, Fujisawa, Sho, Gardner, Rui, Feng, Elvin, Li, Anqi, da Silva, Edaise M., Lozada, John R., Blecua, Pedro, Cohen-Gould, Leona, Jungbluth, Achim A., Rakha, Emad A., Ellis, Ian O., Edelweiss, Maria I. A., Palazzo, Juan, Norton, Larry, Hollmann, Travis, Edelweiss, Marcia, Rubin, Brian P., Weigelt, Britta, Reis-Filho, Jorge S.

“…Granular cell tumors (GCTs) are rare tumors that can arise in multiple anatomical locations, and are characterized by abundant intracytoplasmic granules. The…”
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High-grade encapsulated papillary carcinoma of the breast: an under-recognized entity by Rakha, Emad A, Varga, Zsuzsanna, Elsheik, Somaia, Ellis, Ian O

“…Aims Encapsulated papillary carcinoma (EPC) is a recognized special type of breast carcinoma. Despite compelling evidence indicating its invasive nature,…”
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