Search Results - "RAJEEV GOKHALE"

Biomimicry of microbial polysaccharide hydrogels for tissue engineering and regenerative medicine – A review by Ng, Jian Yao, Obuobi, Sybil, Chua, Mei Ling, Zhang, Chi, Hong, Shiqi, Kumar, Yogesh, Gokhale, Rajeev, Ee, Pui Lai Rachel

“…•Biomimicry of microbial polysaccharide hydrogels as TERM scaffolds is discussed.•Microbial polysaccharides form hydrogels easily but lack…”
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A comparative study of top-down and bottom-up approaches for the preparation of micro/nanosuspensions by Verma, Sudhir, Gokhale, Rajeev, Burgess, Diane J.

“…Nano-sizing offers a promising method for the formulation of poorly aqueous soluble compounds. Nanosuspensions can be prepared by top-down or bottom-up…”
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Physical stability of nanosuspensions: Investigation of the role of stabilizers on Ostwald ripening by Verma, Sudhir, Kumar, Sumit, Gokhale, Rajeev, Burgess, Diane J.

“…The effect of stabilizer type and the amount of micellar solubilized drug on Ostwald ripening of nanosuspensions was investigated. The most probable mechanism…”
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Quality by design approach to understand the process of nanosuspension preparation by Verma, Sudhir, Lan, Yan, Gokhale, Rajeev, Burgess, Diane J.

“…Quality by design (QbD) principles were explored to maximize the understanding of the unit operation of microfluidization, for the preparation of…”
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A brief literature and patent review of nanosuspensions to a final drug product by Chin, William Wei Lim, Parmentier, Johannes, Widzinski, Michael, Tan, En Hui, Gokhale, Rajeev

“…Particle size reduction can be used for enhancing the dissolution of poorly water-soluble drugs in order to enhance bioavailability. In nanosuspensions, the…”
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Quality by Design approach to spray drying processing of crystalline nanosuspensions by Kumar, Sumit, Gokhale, Rajeev, Burgess, Diane J.

“…Quality by Design (QbD) principles were explored to understand spray drying process for the conversion of liquid nanosuspensions into solid nano-crystalline…”
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Polysorbates versus Hydroxypropyl Beta-Cyclodextrin (HPβCD): Comparative Study on Excipient Stability and Stabilization Benefits on Monoclonal Antibodies by Zhang, Hailong, Hong, Shiqi, Tan, Sarah Si Kai, Peng, Tao, Goh, Lucas Yuan Hao, Lam, Kwan Hang, Chow, Keat Theng, Gokhale, Rajeev

“…Polysorbates (PS 20 and PS 80) are the most widely used surfactants in biopharmaceutical formulations to protect proteins from denaturation, aggregation, and…”
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Application of miniaturized near-infrared spectroscopy for quality control of extemporaneous orodispersible films by Foo, Wen Chin, Widjaja, Effendi, Khong, Yuet Mei, Gokhale, Rajeev, Chan, Sui Yung

“…•Miniaturized NIR spectroscopy was applied for quality control of extemporaneous ODF.•SVM classification gave 100% prediction accuracy for drug…”
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Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation by Huang, Jiayi, Hong, Shiqi, Goh, Lucas Yuan Hao, Zhang, Hailong, Peng, Tao, Chow, Keat Theng, Gokhale, Rajeev, Tuliani, Vinod

“…Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are…”
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Mannitol-Coated Hydroxypropyl Methylcellulose as a Directly Compressible Controlled Release Excipient for Moisture-Sensitive Drugs: A Stability Perspective by Kang, Christina Yong Xin, Chow, Keat Theng, Lui, Yuan Siang, Salome, Antoine, Boit, Baptiste, Lefevre, Philippe, Hiew, Tze Ning, Gokhale, Rajeev, Heng, Paul Wan Sia

“…Hydroxypropyl methylcellulose (HPMC) is one of the most commonly used hydrophilic polymers in formulations of matrix tablets for controlled release…”
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High drug load, stable, manufacturable and bioavailable fenofibrate formulations in mesoporous silica: a comparison of spray drying versus solvent impregnation methods by Hong, Shiqi, Shen, Shoucang, Tan, David Cheng Thiam, Ng, Wai Kiong, Liu, Xueming, Chia, Leonard S O, Irwan, Anastasia W, Tan, Reginald, Nowak, Steven A, Marsh, Kennan, Gokhale, Rajeev

“…Encapsulation of drugs in mesoporous silica using co-spray drying process has been recently explored as potential industrial method. However, the impact of…”
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Chlorella vulgaris Extract as a Serum Replacement That Enhances Mammalian Cell Growth and Protein Expression by Ng, Jian Yao, Chua, Mei Ling, Zhang, Chi, Hong, Shiqi, Kumar, Yogesh, Gokhale, Rajeev, Ee, Pui Lai Rachel

“…The global cell culture market is experiencing significant growth due to the rapid advancement in antibody-based and cell-based therapies. Both rely on the…”
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Effect of binders on the release rates of direct molded verapamil tablets using twin-screw extruder in melt granulation by Tan, David Cheng Thiam, Chin, William Wei Lim, Tan, En Hui, Hong, Shiqi, Gu, Wei, Gokhale, Rajeev

“…Conventional manufacturing of pharmaceutical tablets often involves single processes such as blending, granulation, milling and direct compression. A process…”
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Solid state drug-polymer miscibility studies using the model drug ABT-102 by Jog, Rajan, Gokhale, Rajeev, Burgess, Diane J.

“…[Display omitted] Amorphous solid dispersions typically suffer storage stability issues due to: their amorphous nature, high drug loading, uneven…”
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Hot melt extrusion of ion-exchange resin for taste masking by Tan, David Cheng Thiam, Ong, Jeremy Jianming, Gokhale, Rajeev, Heng, Paul Wan Sia

“…[Display omitted] Taste masking is important for some unpleasant tasting bioactives in oral dosage forms. Among many methods available for taste-masking, use…”
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A novel unit-dose approach for the pharmaceutical compounding of an orodispersible film by Foo, Wen Chin, Khong, Yuet Mei, Gokhale, Rajeev, Chan, Sui Yung

“…[Display omitted] Orodispersible films (ODF) have clinical potential as extemporaneous pharmacy preparations for individualized pharmacotherapy. However, the…”
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The influence of pregelatinized starch on the rheology of a gellan gum-collagen IPN hydrogel for 3D bioprinting by Ng, Jian Yao, Yu, Peiyan, Murali, Dhanya Mahalakshmi, Liu, Yuan-Siang, Gokhale, Rajeev, Ee, Pui Lai Rachel

“…Hydrogel scaffolds infused with stem cells are valuable alternatives to skin grafts in replacement of lost host tissues. In a prior study, we developed an…”
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Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled release excipient by Kang, Christina Yong Xin, Foo, Wen Chin, Lam, Kwan Hang, Chow, Keat Theng, Lui, Yuan Siang, Goh, Hui Ping, Salome, Antoine, Boit, Baptiste, Lefevre, Philippe, Hiew, Tze Ning, Gokhale, Rajeev, Heng, Paul Wan Sia

“…[Display omitted] One of the most common forms of controlled release technology for oral drug delivery comprises an active ingredient dispersed in a…”
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Melt spheronization – Direct rotary shaping process for hot melt extrudates by Tun, Thin Yu, Gokhale, Rajeev, Heng, Paul Wan Sia

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Formulation parameters of crystalline nanosuspensions on spray drying processing: A DoE approach by Kumar, Sumit, Xu, Xiaoming, Gokhale, Rajeev, Burgess, Diane J.

“…Nanocrystalline suspensions offer a promising approach to improve dissolution of BCS class II/IV compounds. Spray drying was utilized as a downstream process…”
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