Search Results - "RAJAGOPAL, SRIRAM"

PAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritis by Koushik, Sindhu, Joshi, Nivedita, Nagaraju, Shruthi, Mahmood, Sameer, Mudeenahally, Krishna, Padmavathy, Ramya, Jegatheesan, Sooriya Kumar, Mullangi, Ramesh, Rajagopal, Sriram

“…Peptidyl arginine deiminase 4 (PAD4) is an enzyme that plays an important role in gene expression, turning out genetic code into functional products in the…”
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Emerging role of SETDB1 as a therapeutic target by Karanth, Archana Venkataramana, Maniswami, Radhika Radha, Prashanth, Seema, Govindaraj, Hemalatha, Padmavathy, Ramya, Jegatheesan, Sooriya Kumar, Mullangi, Ramesh, Rajagopal, Sriram

“…Epigenetic changes lead to aberrant gene expression in cancer. SETDB1, a histone lysine methyltransferase plays an important role in methylation and gene…”
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Precariousness and vulnerability: Seafarers in the COVID-19 pandemic by Shan, Desai, Ochs, Cory, Rajagopal, Sriram, Rojas Aldieri, Hugo Andres, Zhang, Pengfei

“…The COVID-19 pandemic significantly affected the world and work in particular, but its effects on the labor market were not evenly distributed. Seafarers, who…”
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Discovery of adamantane based highly potent HDAC inhibitors by Gopalan, Balasubramanian, Ponpandian, Thanasekaran, Kachhadia, Virendra, Bharathimohan, Kuppusamy, Vignesh, Radhakrishnan, Sivasudar, Velaiah, Narayanan, Shridhar, Mandar, Bhonde, Praveen, Rajendran, Saranya, Nithyanandan, Rajagopal, Sriram, Rajagopal, Sridharan

“…Herein, we report the development of highly potent HDAC inhibitors for the treatment of cancer. A series of adamantane and nor-adamantane based HDAC inhibitors…”
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Determination of ulixertinib in mice plasma by LC–MS/MS and its application to a pharmacokinetic study in mice by Kumar, Rajinish, Suresh, P.S., Rudresh, G., Zainuddin, Mohd, Dewang, Purushottam, Kethiri, Ragahava Reddy, Rajagopal, Sriram, Mullangi, Ramesh

“…[Display omitted] •First LC–MS/MS method being reported for quantification of ulixertinib in biological matrix.•Simple sample processing method and shorter run…”
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Development and validation of a highly sensitive method for the determination of abiraterone in rat and human plasma by LC-MS/MS-ESI: application to a pharmacokinetic study by Gurav, Sandip, Punde, Ravindra, Farooqui, Junaid, Zainuddin, Mohd, Rajagopal, Sriram, Mullangi, Ramesh

“…ABSTRACT A highly sensitive, rapid assay method has been developed and validated for the estimation of abiraterone (ART) in rat and human plasma with liquid…”
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Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata by Rajagopal, Sriram, Kumar, R Ajaya, Deevi, Dhanvanthri S, Satyanarayana, Chitkala, Rajagopalan, R

“…Andrographis paniculata plant extract is known to possess a variety of pharmacological activities. Andrographolide, the major constituent of the extract is…”
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Liquid chromatography/tandem mass spectrometry method for quantitative estimation of solutol HS15 and its applications by Bhaskar, V. Vijaya, Middha, Anil, Srivastava, Pratima, Rajagopal, Sriram

“…A rapid, sensitive and selective pseudo MRM（p MRM）-based method for the determination of solutol HS15（SHS15） in rat plasma was developed using liquid…”
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Highly sensitive method for the determination of adenosine by LC-MS/MS-ESI: method validation and scope of application to a pharmacokinetic/pharmacodynamic study by Sharma, Kuldeep, Singh, Radheraman, Giri, Sanjeev, Rajagopal, Sriram, Mullangi, Ramesh

“…ABSTRACT A highly sensitive, rapid assay method has been developed and validated for the estimation of adenosine in rat plasma with liquid chromatography…”
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DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells by Satyanarayana, Chitkala, Deevi, Dhanavanthri S, Rajagopalan, R, Srinivas, Nanduri, Rajagopal, Sriram

“…We determined the effect of andrographolide and one of its novel semi-synthetic analog, DRF 3188, on the cell cycle of MCF 7 breast cancer cells. The effect of…”
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Development and validation of a highly sensitive LC-MS/MS-ESI method for the determination of nobiletin in rat plasma: application to a pharmacokinetic study by Kumar, Avinash, Devaraj, V. C., Giri, Kalpesh C., Giri, Sanjeev, Rajagopal, Sriram, Mullangi, Ramesh

“…ABSTRACT A highly sensitive, rapid assay method has been developed and validated for the estimation of nobiletin in rat plasma with liquid chromatography…”
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How widespread is the usage of the Northern Sea Route as a commercially viable shipping route? A statistical analysis of ship transits from 2011 to 2018 based on empirical data by Rajagopal, Sriram, Zhang, Pengfei

“…We critically examined the usage of Northern Sea Route (NSR) during the 8 year period from 2011 to 2018, using empirical data collected from the NSR…”
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Results of Radiofrequency Ablation of Permanent Atrial Fibrillation of >2 Years Duration and Left Atrial Size >5 cm Using 2-mm Irrigated Tip Ablation Catheter and Targeting Areas of Complex Fractionated Atrial Electrograms by Nair, Mohan, DM, Nayyar, Sachin, DM, Rajagopal, Sriram, DM, Balachander, J., DM, Kumar, Manoj, DM

“…Complex fractionated atrial electrograms (CFAEs) have shown promise as target sites for ablation of atrial fibrillation (AF); however, the data are limited…”
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Bilateral carotid angioplasty and stenting by Henry, Michel, Gopalakrishnan, Lakshmi, Rajagopal, Sriram, Rath, P.C., Henry, Isabelle, Hugel, Michele

“…Bilateral carotid stenosis is generally treated by staged stenting procedure and rarely simultaneously due to concerns about hemodynamic impairment from…”
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Technology and training: How will deck officers transition to operating autonomous and remote-controlled vessels? by Kennard, Alice, Zhang, Pengfei, Rajagopal, Sriram

“…The introduction of autonomous and remote shipping is set to be complex and disruptive.It will question many of the legislative and training frameworks within…”
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PLK4: a link between centriole biogenesis and cancer by Maniswami, Radhika Radha, Prashanth, Seema, Karanth, Archana Venkataramana, Koushik, Sindhu, Govindaraj, Hemalatha, Mullangi, Ramesh, Rajagopal, Sriram, Jegatheesan, Sooriya Kumar

“…Polo like kinase (PLK) is known to play a pivotal role in various cell cycle processes to perpetuate proper division and growth of the cells. Polo like…”
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Synthesis and biological evaluation of [4-(2-phenylethenesulfonylmethyl)phenyl]-quinazolin-4-yl-amines as orally active anti-cancer agents by Sharma, Vedula M., Adi Seshu, K.V., Chandra Sekhar, V., Madan, Sachin, Vishnu, B., Babu, P.Aravind, Vamsee Krishna, C., Sreenu, J., Ravi Krishna, V., Venkateswarlu, A., Rajagopal, Sriram, Ajaykumar, R., Kumar, T.Sravan

“…A new series of [4-(2-phenylethenesulfonylmethyl)phenyl]quinazolin-4-yl-amines was prepared and tested for its in vitro cytotoxic activity against a panel of…”
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Disruption of transforming growth factor ?-regulated laminin receptor function by expression of antisense laminin, a chain RNA in human colon cancer cells by Chakrabarty, Subhas, Liu, Bao Rui, Rajagopal, Sriram

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Breaking the sensitivity limitations of cytochrome P450 oxidation product: Dansyl chloride derivatisation of 4-OH mephenytoin, a CYP2C19 metabolite and its application to in vitro CYP inhibition assay by Vijayabhaskar, V., Srivastava, Pratima, Rajagopal, Sriram

“…•Dansylchloride derivatisation of 4-OH mephenytoin was developed and validated.•Derivatisation helped in increasing the sensitivity by 100–200 fold.•Higher…”
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LC–MS/MS determination of tideglusib, a novel GSK-3β inhibitor in mice plasma and its application to a pharmacokinetic study in mice by Saini, Neeraj Kumar, Suresh, P.S., Lella, Mahalakhsmi, Bhamidipati, Ravi Kanth, Rajagopal, Sriram, Mullangi, Ramesh

“…[Display omitted] •First bioanalytical method being reported for quantification of tideglusib in mice plasma on LC–MS/MS.•Simple sample processing method and…”
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