Search Results - "RAIZADA, Mohan K"

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease by Yang, Tao, Richards, Elaine M., Pepine, Carl J., Raizada, Mohan K.

“…Crosstalk between the gut microbiota and the host has attracted considerable attention owing to its involvement in diverse diseases. Chronic kidney disease…”
Get full text

Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure by Kim, Seungbum, Goel, Ruby, Kumar, Ashok, Qi, Yanfei, Lobaton, Gil, Hosaka, Koji, Mohammed, Mohammed, Handberg, Eileen M, Richards, Elaine M, Pepine, Carl J, Raizada, Mohan K

“…Recent evidence indicates a link between gut pathology and microbiome with hypertension (HTN) in animal models. However, whether this association exists in…”
Get more information

Gut Dysbiosis Is Linked to Hypertension by Yang, Tao, Santisteban, Monica M, Rodriguez, Vermali, Li, Eric, Ahmari, Niousha, Carvajal, Jessica Marulanda, Zadeh, Mojgan, Gong, Minghao, Qi, Yanfei, Zubcevic, Jasenka, Sahay, Bikash, Pepine, Carl J, Raizada, Mohan K, Mohamadzadeh, Mansour

“…Emerging evidence suggests that gut microbiota is critical in the maintenance of physiological homeostasis. This study was designed to test the hypothesis that…”
Get full text

Hypertension-Linked Pathophysiological Alterations in the Gut by Santisteban, Monica M, Qi, Yanfei, Zubcevic, Jasenka, Kim, Seungbum, Yang, Tao, Shenoy, Vinayak, Cole-Jeffrey, Colleen T, Lobaton, Gilberto O, Stewart, Daniel C, Rubiano, Andres, Simmons, Chelsey S, Garcia-Pereira, Fernando, Johnson, Richard D, Pepine, Carl J, Raizada, Mohan K

“…RATIONALE:Sympathetic nervous system control of inflammation plays a central role in hypertension. The gut receives significant sympathetic innervation, is…”
Get full text

Microglial Cells Impact Gut Microbiota and Gut Pathology in Angiotensin II-Induced Hypertension by Sharma, Ravindra K, Yang, Tao, Oliveira, Aline C, Lobaton, Gilberto O, Aquino, Victor, Kim, Seungbum, Richards, Elaine M, Pepine, Carl J, Sumners, Colin, Raizada, Mohan K

“…RATIONALE:Increased microglial activation and neuroinflammation within autonomic brain regions have been implicated in sustained hypertension, and their…”
Get full text

Critical Role of the Interaction Gut Microbiota - Sympathetic Nervous System in the Regulation of Blood Pressure by Toral, Marta, Robles-Vera, Iñaki, de la Visitación, Néstor, Romero, Miguel, Yang, Tao, Sánchez, Manuel, Gómez-Guzmán, Manuel, Jiménez, Rosario, Raizada, Mohan K, Duarte, Juan

“…Association between gut dysbiosis and neurogenic diseases, such as hypertension, has been described. The aim of this study was to investigate whether changes…”
Get full text

Depressive hypertension: A proposed human endotype of brain/gut microbiome dysbiosis by Stevens, Bruce R., Pepine, Carl J., Richards, Elaine M., Kim, Seungbum, Raizada, Mohan K.

“…Hypertension (HTN) is frequently linked with depression (DEP) in adults with cardiovascular disease (CVD), yet the underlying mechanism and successful…”
Get full text

Involvement of Bone Marrow Cells and Neuroinflammation in Hypertension by Santisteban, Monica M, Ahmari, Niousha, Carvajal, Jessica Marulanda, Zingler, Michael B, Qi, Yanfei, Kim, Seungbum, Joseph, Jessica, Garcia-Pereira, Fernando, Johnson, Richard D, Shenoy, Vinayak, Raizada, Mohan K, Zubcevic, Jasenka

“…RATIONALE:Microglial activation in autonomic brain regions is a hallmark of neuroinflammation in neurogenic hypertension. Despite evidence that an impaired…”
Get full text

Brain Microglial Cytokines in Neurogenic Hypertension by Shi, Peng, Diez-Freire, Carlos, Jun, Joo Yun, Qi, Yanfei, Katovich, Michael J, Li, Qiuhong, Sriramula, Srinivas, Francis, Joseph, Sumners, Colin, Raizada, Mohan K

“…Accumulating evidence indicates a key role of inflammation in hypertension and cardiovascular disorders. However, the role of inflammatory processes in…”
Get full text

Direct pro-inflammatory effects of prorenin on microglia by Shi, Peng, Grobe, Justin L, Desland, Fiona A, Zhou, Guannan, Shen, Xiao Z, Shan, Zhiying, Liu, Meng, Raizada, Mohan K, Sumners, Colin

“…Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we…”
Get full text

Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases by Sharma, Ravindra K, Li, Jing, Krishnan, Suraj, Richards, Elaine M, Raizada, Mohan K, Mohandas, Rajesh

“…The rapid spread of the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought into focus the key role of…”
Get more information

Gut Pathology and Its Rescue by ACE2 (Angiotensin-Converting Enzyme 2) in Hypoxia-Induced Pulmonary Hypertension by Sharma, Ravindra K., Oliveira, Aline C., Yang, Tao, Karas, Marianthi M., Li, Jing, Lobaton, Gilberto O., Aquino, Victor P., Robles-Vera, Iñaki, de Kloet, Annette D., Krause, Eric G., Bryant, Andrew J., Verma, Amrisha, Li, Qiuhong, Richards, Elaine M., Raizada, Mohan K.

“…Therapeutic advances for pulmonary hypertension (PH) have been incremental because of the focus on the pulmonary vasculature in PH pathology. Here, we evaluate…”
Get full text

Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia by Park, Sung Ok, Wankhede, Mamta, Lee, Young Jae, Choi, Eun-Jung, Fliess, Naime, Choe, Se-Woon, Oh, Seh-Hoon, Walter, Glenn, Raizada, Mohan K, Sorg, Brian S, Oh, S Paul

“…Arteriovenous malformations (AVMs) are vascular anomalies where arteries and veins are directly connected through a complex, tangled web of abnormal arteries…”
Get full text

ACE2 and Ang-(1-7) Confer Protection Against Development of Diabetic Retinopathy by Verma, Amrisha, Shan, Zhiying, Lei, Bo, Yuan, Lihui, Liu, Xuan, Nakagawa, Takahiko, Grant, Maria B, Lewin, Alfred S, Hauswirth, William W, Raizada, Mohan K, Li, Qiuhong

“…Despite evidence that hyperactivity of the vasodeleterious axis (ACE/angiotensin II (Ang II)/AT1 receptor) of the renin–angiotensin system (RAS) is associated…”
Get full text

ACE2 as therapeutic agent by Li, Qiuhong, Grant, Maria B, Richards, Elaine M, Raizada, Mohan K

“…The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin-angiotensin system (RAS), which plays important roles in…”
Get more information

Therapeutic potential of adipose stem cell‐derived conditioned medium against pulmonary hypertension and lung fibrosis by Rathinasabapathy, Anandharajan, Bruce, Erin, Espejo, Andrew, Horowitz, Alana, Sudhan, Dhivya R, Nair, Anand, Guzzo, Dominic, Francis, Joseph, Raizada, Mohan K, Shenoy, Vinayak, Katovich, Michael J

“…Background and Purpose Pulmonary hypertension (PH) and pulmonary fibrosis (PF) are life threatening cardiopulmonary diseases. Existing pharmacological…”
Get full text

Sustained Captopril-Induced Reduction in Blood Pressure Is Associated With Alterations in Gut-Brain Axis in the Spontaneously Hypertensive Rat by Yang, Tao, Aquino, Victor, Lobaton, Gilberto O, Li, Hongbao, Colon-Perez, Luis, Goel, Ruby, Qi, Yanfei, Zubcevic, Jasenka, Febo, Marcelo, Richards, Elaine M, Pepine, Carl J, Raizada, Mohan K

“…Background We have demonstrated that the antihypertensive effect of the angiotensin-converting enzyme inhibitor, captopril ( CAP ), is associated with…”
Get full text

Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors by Wang, Lei, de Kloet, Annette D., Pati, Dipanwita, Hiller, Helmut, Smith, Justin A., Pioquinto, David J., Ludin, Jacob A., Oh, S. Paul, Katovich, Michael J., Frazier, Charles J., Raizada, Mohan K., Krause, Eric G.

“…Over-activation of the brain renin-angiotensin system (RAS) has been implicated in the etiology of anxiety disorders. Angiotensin converting enzyme 2 (ACE2)…”
Get full text

Elevated bone marrow sympathetic drive precedes systemic inflammation in angiotensin II hypertension by Ahmari, Niousha, Santisteban, Monica M, Miller, Douglas R, Geis, Natalie M, Larkin, Riley, Redler, Ty, Denson, Heather, Khoshbouei, Habibeh, Baekey, David M, Raizada, Mohan K, Zubcevic, Jasenka

“…Increased sympathetic nervous system activity is a hallmark of hypertension (HTN), and it is implicated in altered immune system responses in its…”
Get more information

Overexpression of Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Causes Long-Term Decrease in Blood Pressure in the Spontaneously Hypertensive Rats by Yamazato, Masanobu, Yamazato, Yoriko, Sun, Chengwen, Diez-Freire, Carlos, Raizada, Mohan K

“…The rostral ventrolateral medulla (RVLM) is a relay point that provides supraspinal excitatory input to sympathetic preganglionic neurons in the regulation of…”
Get full text