Search Results - "RAINER, Georg"

Nintedanib in Progressive Fibrosing Interstitial Lung Diseases by Flaherty, Kevin R, Wells, Athol U, Cottin, Vincent, Devaraj, Anand, Walsh, Simon L.F, Inoue, Yoshikazu, Richeldi, Luca, Kolb, Martin, Tetzlaff, Kay, Stowasser, Susanne, Coeck, Carl, Clerisme-Beaty, Emmanuelle, Rosenstock, Bernd, Quaresma, Manuel, Haeufel, Thomas, Goeldner, Rainer-Georg, Schlenker-Herceg, Rozsa, Brown, Kevin K

“…In patients with a progressive interstitial lung disease, 62% of whom had a CT pattern of usual interstitial pneumonia, those who received nintedanib had a…”
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Microbial biomass, fungal and bacterial residues, and their relationships to the soil organic matter C/N/P/S ratios by Khan, Khalid Saifullah, Mack, Ralf, Castillo, Xiomara, Kaiser, Michael, Joergensen, Rainer Georg

“…The interrelations between the microbial biomass, total N, organic P, and organic S in the accumulation of soil organic C (SOC) and the contribution of fungal…”
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Pathways of nitrogen utilization by soil microorganisms – A review by Geisseler, Daniel, Horwath, William R., Joergensen, Rainer Georg, Ludwig, Bernard

“…Microorganisms are able to utilize nitrogen (N) from a wide range of organic and mineral compounds. In this paper, we review the current knowledge about the…”
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Predictors of mortality in subjects with progressive fibrosing interstitial lung diseases by Brown, Kevin K., Inoue, Yoshikazu, Flaherty, Kevin R., Martinez, Fernando J., Cottin, Vincent, Bonella, Francesco, Cerri, Stefania, Danoff, Sonye K., Jouneau, Stephane, Goeldner, Rainer‐Georg, Schmidt, Martin, Stowasser, Susanne, Schlenker‐Herceg, Rozsa, Wells, Athol U.

“…Background and objective Demographic and clinical variables, measured at baseline or over time, have been associated with mortality in subjects with…”
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Safety, tolerability and pharmacokinetics of the phosphodiesterase 2 inhibitor BI 474121: An overview of phase I randomized trials in healthy volunteers by Schaible, Jennifer, Scholz, Andreas, Goeldner, Rainer-Georg, Yamamura, Norio

“…Background: Cognitive impairment associated with schizophrenia predicts poor functional outcomes, but currently no efficacious pharmacotherapies are available…”
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Pharmacokinetics of Afatinib, a Selective Irreversible ErbB Family Blocker, in Patients with Advanced Solid Tumours by Wind, Sven, Schmid, Marion, Erhardt, Julia, Goeldner, Rainer-Georg, Stopfer, Peter

“…Background and Objective Afatinib is a potent, irreversible, ErbB family blocker in clinical development for the treatment of a variety of solid tumours. This…”
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Nintedanib in progressive interstitial lung diseases: data from the whole INBUILD trial by Flaherty, Kevin R, Wells, Athol U, Cottin, Vincent, Devaraj, Anand, Inoue, Yoshikazu, Richeldi, Luca, Walsh, Simon L F, Kolb, Martin, Koschel, Dirk, Moua, Teng, Stowasser, Susanne, Goeldner, Rainer-Georg, Schlenker-Herceg, Rozsa, Brown, Kevin K

“…The primary analysis of the INBUILD trial showed that in subjects with progressive fibrosing interstitial lung diseases (ILDs), nintedanib slowed the decline…”
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Effects of the phosphodiesterase 2 inhibitor BI 474121 on central nervous system cyclic guanosine monophosphate concentrations: Translational studies by Kraaij, Sebastiaan, Goeldner, Rainer‐Georg, Rosenbrock, Holger, Groeneveld, Geert Jan, Kremer, Philip, Schaible, Jennifer, Zambori, Janos, Schultheis, Christian

“…Aims Phosphodiesterase 2 (PDE2) regulates intracellular cyclic adenosine monophosphate and guanosine monophosphate (cAMP/cGMP) levels, which contribute to…”
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Nintedanib in patients with progressive fibrosing interstitial lung diseases—subgroup analyses by interstitial lung disease diagnosis in the INBUILD trial: a randomised, double-blind, placebo-controlled, parallel-group trial by Flaherty, Kevin R, Brown, Kevin K, Inoue, Yoshikazu, Moua, Teng, Crestani, Bruno, Wuyts, Wim A, Stowasser, Susanne, Quaresma, Manuel, Goeldner, Rainer-Georg, Schlenker-Herceg, Rozsa, Kolb, Martin, Aburto, M., Acosta, O., Antin-Ozerkis, D., Arce, G., Barczyk, A., Bascom, R., Bazdyrev, E., Belloli, E., Bergna, M.A., Blaas, S., Bondue, B., Bonella, F., Cantin, A., Castillo Villegas, D.M., Cazaux, A., Cerri, S., Cottin, V., Crestani, B., Dahlqvist, C., Danoff, S., Dematte D'Amico, J., Dilling, D., Elias, P., Falk, J., Fernández Pérez, E.R., Gamez-Dubuis, A., Giessel, G., Glassberg, M., Glazer, C., Guiot, J., Hirani, N., Homik, L., Hope-Gill, B., Hotchkin, D., Ilkovich, M., Inoue, Y., Jassem, E., Jones, L., Kitamura, H., Kolb, M., Kono, C., Kulkarni, T., León Jiménez, A., Luo, Q., Mageto, Y., Maher, T.M., Makino, S., Martinez, R., Martínez, M., Miyazaki, Y., Morrison, L., Morrow, L., Moua, T., Nambiar, A., Nunes, H., Okamoto, M., Otaola, M., Park, J.S., Patel, N., Pesci, A., Poonyagariyagorn, H., Quadrelli, S., Randerath, W., Reynaud-Gaubert, M., Rosas, I., Safdar, Z., Saito, T., Sakamoto, N., Schmidt, S., Scholand, M.B., Shapera, S., Shlobin, O., Sigal, B., Silva Orellana, A., Song, J.W., Stone, H., Sugiura, H., Takaya, H., Takeuchi, T., Thavarajah, K., Tolle, L., Tomii, K., Valenzuela, C., Vancheri, C., Varone, F., Veeraraghavan, S., Wemeau, L., Yakusevich, V., Yamada, Y.

“…The INBUILD trial investigated the efficacy and safety of nintedanib versus placebo in patients with progressive fibrosing interstitial lung diseases (ILDs)…”
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Impact of salinity on soil microbial communities and the decomposition of maize in acidic soils by Wichern, Jannike, Wichern, Florian, Joergensen, Rainer Georg

“…Soil salinity, as an increasingly important process of land degradation, is a major threat to microbial communities and thus strongly alters organic matter…”
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Shifts in amino sugar and ergosterol contents after addition of sucrose and cellulose to soil by Engelking, Brigitte, Flessa, Heiner, Joergensen, Rainer Georg

“…An incubation experiment with organic soil amendments was carried out with the aim to determine whether formation and use of microbial tissue (biomass and…”
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A phase I trial investigating the Aurora B kinase inhibitor BI 811283 in combination with cytarabine in patients with acute myeloid leukaemia by Döhner, Hartmut, Müller‐Tidow, Carsten, Lübbert, Michael, Fiedler, Walter, Krämer, Alwin, Westermann, Jörg, Bug, Gesine, Schlenk, Richard F., Krug, Utz, Goeldner, Rainer‐Georg, Hilbert, James, Taube, Tillmann, Ottmann, Oliver G.

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Rate of soil‐aggregate formation under different organic matter amendments—a short‐term incubation experiment by Andruschkewitsch, Rouven, Geisseler, Daniel, Dultz, Stefan, Joergensen, Rainer‐Georg, Ludwig, Bernard

“…To improve soil structure and take advantage of several accompanying ecological benefits, it is necessary to understand the underlying processes of aggregate…”
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Mycorrhiza response and phosphorus acquisition efficiency of sorghum cultivars differing in strigolactone composition by Abdelhalim, Tilal, Jannoura, Ramia, Joergensen, Rainer Georg

“…Aims The function of strigolactone isomers in sorghum phosphorus acquisition efficiency (PAE) is still a matter of speculation. Therefore, the objective of…”
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Relationships between feeding and microbial faeces indices in dairy cows at different milk yield levels by Meyer, Stephanie, Thiel, Volker, Joergensen, Rainer Georg, Sundrum, Albert

“…A study was carried out to gain quantitative information on the diet-dependent faecal microbial biomass of dairy cows, especially on the biomass fractions of…”
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Microbial residue indices down the soil profile after long-term addition of farmyard manure and mineral fertilizer to a sandy soil by Sradnick, André, Oltmanns, Meike, Raupp, Joachim, Joergensen, Rainer Georg

“…Long-term organic fertilization may control the accumulation of organic matter in subsoil. The objective of this study was to evaluate the effects of long-term…”
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Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours by de Bono, Johann, Lin, Chia-Chi, Chen, Li-Tzong, Corral, Jesus, Michalarea, Vasiliki, Rihawi, Karim, Ong, Michael, Lee, Jih-Hsiang, Hsu, Chih-Hung, Yang, James Chih-Hsin, Shiah, Her-Shyong, Yen, Chia-Jui, Anthoney, Alan, Jove, Maria, Buschke, Susanne, Fuertig, René, Schmid, Ulrike, Goeldner, Rainer-Georg, Strelkowa, Natalja, Huang, Dennis Chin-Lun, Bogenrieder, Thomas, Twelves, Chris, Cheng, Ann-Lii

“…Background Xentuzumab, an insulin-like growth factor (IGF)-1/IGF-2-neutralising antibody, binds IGF-1 and IGF-2, inhibiting their growth-promoting signalling…”
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Effects of nintedanib by inclusion criteria for progression of interstitial lung disease by Maher, Toby M, Brown, Kevin K, Kreuter, Michael, Devaraj, Anand, Walsh, Simon L F, Lancaster, Lisa H, Belloli, Elizabeth A, Padilla, Maria, Behr, Juergen, Goeldner, Rainer-Georg, Tetzlaff, Kay, Schlenker-Herceg, Rozsa, Flaherty, Kevin R

“…The INBUILD trial investigated nintedanib placebo in patients with progressive fibrosing interstitial lung diseases (ILDs). We investigated the decline in…”
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Soil microbial properties of subalpine steppe soils at different grazing intensities in the Chinese Altai Mountains by Goenster-Jordan, Sven, Ingold, Mariko, Jannoura, Ramia, Buerkert, Andreas, Joergensen, Rainer Georg

“…Long-term provision of ecosystem services by grasslands is threatened by increasing stocking densities. The functions of grassland ecosystems depend on a…”
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Phase I trial of afatinib and 3-weekly trastuzumab with optimal anti-diarrheal management in patients with HER2-positive metastatic cancer by Martin, Nicolas, Isambert, Nicolas, Gomez-Roca, Carlos, Goeldner, Rainer-Georg, Zanetta, Sylvie, Sadrolhefazi, Behbood, de Mont-Serrat, Hélène, Campone, Mario, Delord, Jean-Pierre

“…Background Trastuzumab is the mainstay of therapy for patients with HER2-positive breast and gastric cancer but resistance frequently occurs. Afatinib, an…”
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