Search Results - "RAFI AHMED"

High antigen levels are the cause of T cell exhaustion during chronic viral infection by Mueller, Scott N, Ahmed, Rafi

“…Many persistent viral infections induce dysfunctional T cell responses. Although a negative correlation exists between viral load and T cell responses during…”
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Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus by Priyamvada, Lalita, Quicke, Kendra M., Hudson, William H., Onlamoon, Nattawat, Sewatanon, Jaturong, Edupuganti, Srilatha, Pattanapanyasat, Kovit, Chokephaibulkit, Kulkanya, Mulligan, Mark J., Wilson, Patrick C., Ahmed, Rafi, Suthar, Mehul S., Wrammert, Jens

“…Zika virus (ZIKV) is an emerging mosquito-borne flavivirus of significant public health concern. ZIKV shares a high degree of sequence and structural homology…”
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Manipulating the PD-1 pathway to improve immunity by Kamphorst, Alice O, Ahmed, Rafi

“…Highlights • Blocking PD-1 signaling rescues exhausted T cells in chronic infections and cancer. • PD-1 pathway blockade unleashes effector T cell functions on…”
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Comparison of the toxicity profile of PD‐1 versus PD‐L1 inhibitors in non–small cell lung cancer: A systematic analysis of the literature by Pillai, Rathi N., Behera, Madhusmita, Owonikoko, Taofeek K., Kamphorst, Alice O., Pakkala, Suchita, Belani, Chandra P., Khuri, Fadlo R., Ahmed, Rafi, Ramalingam, Suresh S.

“…BACKGROUND Monoclonal antibodies against programmed cell death protein 1 (PD‐1) and programmed death ligand 1 (PD‐L1) are effective therapies in patients with…”
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Humoral cross-reactivity between Zika and dengue viruses: implications for protection and pathology by Priyamvada, Lalita, Hudson, William, Ahmed, Rafi, Wrammert, Jens

“…Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that has recently caused extensive outbreaks in Central and South America and the Caribbean. Given…”
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PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition by Li, Kaitao, Yuan, Zhou, Lyu, Jintian, Ahn, Eunseon, Davis, Simon J., Ahmed, Rafi, Zhu, Cheng

“…Despite the clinical success of blocking its interactions, how PD-1 inhibits T-cell activation is incompletely understood, as exemplified by its potency far…”
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A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation by Paunovska, Kalina, Sago, Cory D, Monaco, Christopher M, Hudson, William H, Castro, Marielena Gamboa, Rudoltz, Tobi G, Kalathoor, Sujay, Vanover, Daryll A, Santangelo, Philip J, Ahmed, Rafi, Bryksin, Anton V, Dahlman, James E

“…Endothelial cells and macrophages play active roles in disease and as a result are important targets for nucleic acid therapies. While thousands of chemically…”
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Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination by Ellebedy, Ali H, Jackson, Katherine J L, Kissick, Haydn T, Nakaya, Helder I, Davis, Carl W, Roskin, Krishna M, McElroy, Anita K, Oshansky, Christine M, Elbein, Rivka, Thomas, Shine, Lyon, George M, Spiropoulou, Christina F, Mehta, Aneesh K, Thomas, Paul G, Boyd, Scott D, Ahmed, Rafi

“…Immunologic memory promotes faster and more-efficient responses after re-exposure to pathogens. Ahmed and colleagues characterize a subset of human B cells…”
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Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza by Zarnitsyna, Veronika I, Lavine, Jennie, Ellebedy, Ali, Ahmed, Rafi, Antia, Rustom

“…The development of next-generation influenza vaccines that elicit strain-transcendent immunity against both seasonal and pandemic viruses is a key public…”
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The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection by Wherry, E John, Sharpe, Arlene H, Ahmed, Rafi, Freeman, Gordon J

“…The programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-L2. Studies have shown that PD-1-PD-L interactions control the induction…”
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Strength of PD-1 signaling differentially affects T-cell effector functions by Wei, Fang, Zhong, Shi, Ma, Zhengyu, Kong, Hong, Medvec, Andrew, Ahmed, Rafi, Freeman, Gordon J, Krogsgaard, Michelle, Riley, James L

“…High surface expression of programmed death 1 (PD-1) is associated with T-cell exhaustion; however, the relationship between PD-1 expression and T-cell…”
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Influenza vaccine-induced human bone marrow plasma cells decline within a year after vaccination by Davis, Carl W, Jackson, Katherine J L, McCausland, Megan M, Darce, Jaime, Chang, Cathy, Linderman, Susanne L, Chennareddy, Chakravarthy, Gerkin, Rebecca, Brown, Shantoria J, Wrammert, Jens, Mehta, Aneesh K, Cheung, Wan Cheung, Boyd, Scott D, Waller, Edmund K, Ahmed, Rafi

“…A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains…”
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Metabolic Phenotypes of Response to Vaccination in Humans by Li, Shuzhao, Sullivan, Nicole L., Rouphael, Nadine, Yu, Tianwei, Banton, Sophia, Maddur, Mohan S., McCausland, Megan, Chiu, Christopher, Canniff, Jennifer, Dubey, Sheri, Liu, Ken, Tran, ViLinh, Hagan, Thomas, Duraisingham, Sai, Wieland, Andreas, Mehta, Aneesh K., Whitaker, Jennifer A., Subramaniam, Shankar, Jones, Dean P., Sette, Alessandro, Vora, Kalpit, Weinberg, Adriana, Mulligan, Mark J., Nakaya, Helder I., Levin, Myron, Ahmed, Rafi, Pulendran, Bali

“…Herpes zoster (shingles) causes significant morbidity in immune compromised hosts and older adults. Whereas a vaccine is available for prevention of shingles,…”
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CXCL13 is a plasma biomarker of germinal center activity by Havenar-Daughton, Colin, Lindqvist, Madelene, Heit, Antje, Wu, Jennifer E., Reiss, Samantha M., Kendric, Kayla, Bélanger, Simon, Kasturi, Sudhir Pai, Landais, Elise, Akondy, Rama S., McGuire, Helen M., Bothwell, Marcella, Vagefi, Parsia A., Scully, Eileen, Tomarasm, Georgia D., Davis, Mark M., Poignard, Pascal, Ahmed, Rafi, Walker, Bruce D., Pulendran, Bali, McElrath, M. Juliana, Kaufmann, Daniel E., Crotty, Shane

“…Significantly higher levels of plasma CXCL13 [chemokine (C-X-C motif) ligand 13] were associated with the generation of broadly neutralizing antibodies (bnAbs)…”
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Immune history profoundly affects broadly protective B cell responses to influenza by Andrews, Sarah F, Huang, Yunping, Kaur, Kaval, Popova, Lyubov I, Ho, Irvin Y, Pauli, Noel T, Henry Dunand, Carole J, Taylor, William M, Lim, Samuel, Huang, Min, Qu, Xinyan, Lee, Jane-Hwei, Salgado-Ferrer, Marlene, Krammer, Florian, Palese, Peter, Wrammert, Jens, Ahmed, Rafi, Wilson, Patrick C

“…Generating a broadly protective influenza vaccine is critical to global health. Understanding how immune memory influences influenza immunity is central to…”
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Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection by Jin, Hyun-Tak, Anderson, Ana C., Tan, Wendy G., West, Erin E., Ha, Sang-Jun, Araki, Koichi, Freeman, Gordon J., Kuchroo, Vijay K., Ahmed, Rafi

“…Inhibitory receptors play a crucial role in regulating CD8 T-cell function during chronic viral infection. T-cell Ig- and mucin-domain–containing molecule–3…”
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mTOR regulates T cell exhaustion and PD-1-targeted immunotherapy response during chronic viral infection by Ando, Satomi, Perkins, Charles M, Sajiki, Yamato, Chastain, Chase, Valanparambil, Rajesh M, Wieland, Andreas, Hudson, William H, Hashimoto, Masao, Ramalingam, Suresh S, Freeman, Gordon J, Ahmed, Rafi, Araki, Koichi

“…T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8+ T cells are maintained by…”
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Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy by Wang, Taia T., Maamary, Jad, Tan, Gene S., Bournazos, Stylianos, Davis, Carl W., Krammer, Florian, Schlesinger, Sarah J., Palese, Peter, Ahmed, Rafi, Ravetch, Jeffrey V.

“…Protective vaccines elicit high-affinity, neutralizing antibodies by selection of somatically hypermutated B cell antigen receptors (BCR) on immune complexes…”
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Photobiomodulation in acceleration of orthodontic tooth movement: A systematic review and meta analysis by AlShahrani, Ibrahim, Togoo, Rafi Ahmed, Hosmani, Jagadish, Alhaizaey, Ali

“…•Photobiomodulation therapy is widely been used to accelerate the tooth movement and alleviate pain during the course of orthodontic treatment.•Systematic…”
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Enhancing SIV-specific immunity in vivo by PD-1 blockade by Vanderford, Thomas H, Velu, Vijayakumar, Titanji, Kehmia, Ahmed, Rafi, Amara, Rama Rao, Lai, Lilin, Pladevega, Annette, Freeman, Gordon J, Husain, Sajid, Zhu, Baogong, Chennareddi, Lakshmi, Silvestri, Guido

“…Chronic immunodeficiency virus infections are characterized by dysfunctional cellular and humoral antiviral immune responses. As such, immune modulatory…”
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