Search Results - "RAES, Adam L"

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues by Labro, Alain J, Raes, Adam L, Grottesi, Alessandro, Van Hoorick, Diane, Sansom, Mark S P, Snyders, Dirk J

“…Voltage-dependent K(+) channels transfer the voltage sensor movement into gate opening or closure through an electromechanical coupling. To test functionally…”
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Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels by Cuypers, Eva, Abdel-Mottaleb, Yousra, Kopljar, Ivan, Rainier, Jon D., Raes, Adam L., Snyders, Dirk J., Tytgat, Jan

“…In this study, we pharmacologically characterized gambierol, a marine polycyclic ether toxin which is produced by the dinoflagellate Gambierdiscus toxicus…”
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Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons by Bocksteins, Elke, Raes, Adam L, Van de Vijver, Gerda, Bruyns, Tine, Van Bogaert, Pierre-Paul, Snyders, Dirk J

“…Silent voltage-gated K(+) (K(v)) subunits interact with K(v)2 subunits and primarily modulate the voltage dependence of inactivation of these heterotetrameric…”
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Role of the S6 C-terminus in KCNQ1 channel gating by Boulet, Inge R., Labro, Alain J., Raes, Adam L., Snyders, Dirk J.

“…Co-assembly of KCNQ1 α-subunits with KCNE1 β-subunits results in the channel complex underlying the cardiac I Ks current in vivo . Like other voltage-gated K…”
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Gating of Shaker-type Channels Requires the Flexibility of S6 Caused by Prolines by Labro, Alain J., Raes, Adam L., Bellens, Iris, Ottschytsch, Natacha, Snyders, Dirk J.

“…The recent crystallization of a voltage-gated K+ channel has given insight into the structure of these channels but has not resolved the issues of the location…”
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Domain analysis of Kv6.3, an electrically silent channel by Ottschytsch, Natacha, Raes, Adam L., Timmermans, Jean‐Pierre, Snyders, Dirk J.

“…The subunit Kv6.3 encodes a voltage-gated potassium channel belonging to the group of electrically silent Kv subunits, i.e. subunits that do not form…”
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The S4-S5 Linker of KCNQ1 Channels Forms a Structural Scaffold with the S6 Segment Controlling Gate Closure by Labro, Alain J., Boulet, Inge R., Choveau, Frank S., Mayeur, Evy, Bruyns, Tine, Loussouarn, Gildas, Raes, Adam L., Snyders, Dirk J.

“…In vivo, KCNQ1 α-subunits associate with the β-subunit KCNE1 to generate the slowly activating cardiac potassium current (IKs). Structurally, they share their…”
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Functional effects of a KCNQ1 mutation associated with the long QT syndrome by BOULET, Inge R, RAES, Adam L, OTTSCHYTSCH, Natacha, SNYDERS, Dirk J

“…Long QT syndrome (LQTS) is an inherited disorder of ventricular repolarization caused by mutations in cardiac ion channel genes, including KCNQ1. In this study…”
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A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics by Labro, Alain J, Grottesi, Alessandro, Sansom, Mark S P, Raes, Adam L, Snyders, Dirk J

“…The Kv1-4 families of K+ channels contain a tandem proline motif (PXP) in the S6 helix that is crucial for channel gating. In human Kv1.5, replacing the first…”
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Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels by Labro, Alain J, Raes, Adam L, Snyders, Dirk J

“…Voltage-gated K(+) channels play a central role in the modulation of excitability. In these channels, the voltage-dependent movement of the voltage sensor…”
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Substitution Scan of the S4-S5 Linker Region in KCNQ1 Channel: Structural Scaffold for Critical Protein Interactions by Labro, Alain J., Boulet, Inge R., Raes, Adam L., Snyders, Dirk J.

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A P-helix Mutant In A Shaker-type Kv Channel Converts The Inactivated State Into A Conducting One by Labro, Alain J., Grottesi, Alessandro, Raes, Adam L., Snyders, Dirk J.

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