Search Results - "RADLWIMMER, Bernhard"

Tagmentation-based whole-genome bisulfite sequencing by Wang, Qi, Gu, Lei, Adey, Andrew, Radlwimmer, Bernhard, Wang, Wei, Hovestadt, Volker, Bähr, Marion, Wolf, Stephan, Shendure, Jay, Eils, Roland, Plass, Christoph, Weichenhan, Dieter

“…Epigenetic modifications such as carbon 5 methylation of the cytosine base in a CpG dinucleotide context are involved in the onset and progression of human…”
Get full text

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype by Wu, Yonghe, Fletcher, Michael, Gu, Zuguang, Wang, Qi, Costa, Barbara, Bertoni, Anna, Man, Ka-Hou, Schlotter, Magdalena, Felsberg, Jörg, Mangei, Jasmin, Barbus, Martje, Gaupel, Ann-Christin, Wang, Wei, Weiss, Tobias, Eils, Roland, Weller, Michael, Liu, Haikun, Reifenberger, Guido, Korshunov, Andrey, Angel, Peter, Lichter, Peter, Herrmann, Carl, Radlwimmer, Bernhard

“…Glioblastoma frequently exhibits therapy-associated subtype transitions to mesenchymal phenotypes with adverse prognosis. Here, we perform multi-omic profiling…”
Get full text

Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis by Körber, Verena, Yang, Jing, Barah, Pankaj, Wu, Yonghe, Stichel, Damian, Gu, Zuguang, Fletcher, Michael Nai Chung, Jones, David, Hentschel, Bettina, Lamszus, Katrin, Tonn, Jörg Christian, Schackert, Gabriele, Sabel, Michael, Felsberg, Jörg, Zacher, Angela, Kaulich, Kerstin, Hübschmann, Daniel, Herold-Mende, Christel, von Deimling, Andreas, Weller, Michael, Radlwimmer, Bernhard, Schlesner, Matthias, Reifenberger, Guido, Höfer, Thomas, Lichter, Peter

“…We studied how intratumoral genetic heterogeneity shapes tumor growth and therapy response for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly…”
Get full text

Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation by Edrei, Yifat, Levy, Revital, Kaye, Daniel, Marom, Anat, Radlwimmer, Bernhard, Hellman, Asaf

“…Common diseases manifest differentially between patients, but the genetic origin of this variation remains unclear. To explore possible involvement of gene…”
Get full text

Rapid, adaptable and sensitive Cas13-based COVID-19 diagnostics using ADESSO by Casati, Beatrice, Verdi, Joseph Peter, Hempelmann, Alexander, Kittel, Maximilian, Klaebisch, Andrea Gutierrez, Meister, Bianca, Welker, Sybille, Asthana, Sonal, Di Giorgio, Salvatore, Boskovic, Pavle, Man, Ka Hou, Schopp, Meike, Ginno, Paul Adrian, Radlwimmer, Bernhard, Stebbins, Charles Erec, Miethke, Thomas, Papavasiliou, Fotini Nina, Pecori, Riccardo

“…During the ongoing COVID-19 pandemic, PCR testing and antigen tests have proven critical for helping to stem the spread of its causative agent, SARS-CoV-2…”
Get full text

Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups by Weller, Michael, Weber, Ruthild G., Willscher, Edith, Riehmer, Vera, Hentschel, Bettina, Kreuz, Markus, Felsberg, Jörg, Beyer, Ulrike, Löffler-Wirth, Henry, Kaulich, Kerstin, Steinbach, Joachim P., Hartmann, Christian, Gramatzki, Dorothee, Schramm, Johannes, Westphal, Manfred, Schackert, Gabriele, Simon, Matthias, Martens, Tobias, Boström, Jan, Hagel, Christian, Sabel, Michael, Krex, Dietmar, Tonn, Jörg C., Wick, Wolfgang, Noell, Susan, Schlegel, Uwe, Radlwimmer, Bernhard, Pietsch, Torsten, Loeffler, Markus, von Deimling, Andreas, Binder, Hans, Reifenberger, Guido

“…Cerebral gliomas of World Health Organization (WHO) grade II and III represent a major challenge in terms of histological classification and clinical…”
Get full text

Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients by ZEPPERNICK, Felix, AHMADI, Rezvan, CAMPOS, Benito, DICTUS, Christine, HELMKE, Burkhard M, BECKER, Natalia, LICHTER, Peter, UNTERBERG, Andreas, RADLWIMMER, Bernhard, HEROLD-MENDE, Christel C

“…Purpose: The CD133 antigen has been identified as a putative stem cell marker in normal and malignant brain tissues. In gliomas, it is used to enrich a…”
Get full text

Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors by Neumann, Olaf, Kesselmeier, Miriam, Geffers, Robert, Pellegrino, Rossella, Radlwimmer, Bernhard, Hoffmann, Katrin, Ehemann, Volker, Schemmer, Peter, Schirmacher, Peter, Lorenzo Bermejo, Justo, Longerich, Thomas

“…To identify new tumor‐suppressor gene candidates relevant for human hepatocarcinogenesis, we performed genome‐wide methylation profiling and vertical…”
Get full text

The Endogenous Tryptophan Metabolite and NAD+ Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress by SAHM, Felix, OEZEN, Iris, PLATTEN, Michael, OPITZ, Christiane A, RADLWIMMER, Bernhard, VON DEIMLING, Andreas, AHRENDT, Tilman, ADAMS, Seray, BODE, Helge B, GUILLEMIN, Gilles J, WICK, Wolfgang

“…Quinolinic acid is a product of tryptophan degradation and may serve as a precursor for NAD(+), an important enzymatic cofactor for enzymes such as the DNA…”
Get full text

Targeting Self-Renewal in High-Grade Brain Tumors Leads to Loss of Brain Tumor Stem Cells and Prolonged Survival by Zhu, Zhe, Khan, Muhammad Amir, Weiler, Markus, Blaes, Jonas, Jestaedt, Leonie, Geibert, Madeleine, Zou, Peng, Gronych, Jan, Bernhardt, Olga, Korshunov, Andrey, Bugner, Verena, Lichter, Peter, Radlwimmer, Bernhard, Heiland, Sabine, Bendszus, Martin, Wick, Wolfgang, Liu, Hai-Kun

“…Cancer stem cells (CSCs) have been suggested as potential therapeutic targets for treating malignant tumors, but the in vivo supporting evidence is still…”
Get full text

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma by Wiestler, Benedikt, Capper, David, Sill, Martin, Jones, David T. W., Hovestadt, Volker, Sturm, Dominik, Koelsche, Christian, Bertoni, Anna, Schweizer, Leonille, Korshunov, Andrey, Weiß, Elisa K., Schliesser, Maximilian G., Radbruch, Alexander, Herold-Mende, Christel, Roth, Patrick, Unterberg, Andreas, Hartmann, Christian, Pietsch, Torsten, Reifenberger, Guido, Lichter, Peter, Radlwimmer, Bernhard, Platten, Michael, Pfister, Stefan M., von Deimling, Andreas, Weller, Michael, Wick, Wolfgang

“…The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular classification of anaplastic gliomas based on large-scale genomic or…”
Get full text

Differentiation therapy exerts antitumor effects on stem-like glioma cells by Campos, Benito, Wan, Feng, Farhadi, Mohammad, Ernst, Aurélie, Zeppernick, Felix, Tagscherer, Katrin E, Ahmadi, Rezvan, Lohr, Jennifer, Dictus, Christine, Gdynia, Georg, Combs, Stephanie E, Goidts, Violaine, Helmke, Burkhard M, Eckstein, Volker, Roth, Wilfried, Beckhove, Philipp, Lichter, Peter, Unterberg, Andreas, Radlwimmer, Bernhard, Herold-Mende, Christel

“…Stem-like tumor cells comprise a highly tumorigenic and therapy-resistant tumor subpopulation, which is believed to substantially influence tumor initiation…”
Get full text

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas by Pfister, Stefan, Janzarik, Wibke G, Remke, Marc, Ernst, Aurélie, Werft, Wiebke, Becker, Natalia, Toedt, Grischa, Wittmann, Andrea, Kratz, Christian, Olbrich, Heike, Ahmadi, Rezvan, Thieme, Barbara, Joos, Stefan, Radlwimmer, Bernhard, Kulozik, Andreas, Pietsch, Torsten, Herold-Mende, Christel, Gnekow, Astrid, Reifenberger, Guido, Korshunov, Andrey, Scheurlen, Wolfram, Omran, Heymut, Lichter, Peter

“…The molecular pathogenesis of pediatric astrocytomas is still poorly understood. To further understand the genetic abnormalities associated with these tumors,…”
Get full text

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema by Manner, Johanna, Radlwimmer, Bernhard, Hohenberger, Peter, Mössinger, Katharina, Küffer, Stefan, Sauer, Christian, Belharazem, Djeda, Zettl, Andreas, Coindre, Jean-Michel, Hallermann, Christian, Hartmann, Jörg Thomas, Katenkamp, Detlef, Katenkamp, Kathrin, Schöffski, Patrick, Sciot, Raf, Wozniak, Agnieszka, Lichter, Peter, Marx, Alexander, Ströbel, Philipp

“…Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema. The…”
Get full text

Molecular characterization of long‐term survivors of glioblastoma using genome‐ and transcriptome‐wide profiling by Reifenberger, Guido, Weber, Ruthild G., Riehmer, Vera, Kaulich, Kerstin, Willscher, Edith, Wirth, Henry, Gietzelt, Jens, Hentschel, Bettina, Westphal, Manfred, Simon, Matthias, Schackert, Gabriele, Schramm, Johannes, Matschke, Jakob, Sabel, Michael C., Gramatzki, Dorothee, Felsberg, Jörg, Hartmann, Christian, Steinbach, Joachim P., Schlegel, Uwe, Wick, Wolfgang, Radlwimmer, Bernhard, Pietsch, Torsten, Tonn, Jörg C., von Deimling, Andreas, Binder, Hans, Weller, Michael, Loeffler, Markus

“…The prognosis of glioblastoma, the most malignant type of glioma, is still poor, with only a minority of patients showing long‐term survival of more than three…”
Get full text

Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB by Garding, Angela, Bhattacharya, Nupur, Claus, Rainer, Ruppel, Melanie, Tschuch, Cordula, Filarsky, Katharina, Idler, Irina, Zucknick, Manuela, Caudron-Herger, Maïwen, Oakes, Christopher, Fleig, Verena, Keklikoglou, Ioanna, Allegra, Danilo, Serra, Leticia, Thakurela, Sudhir, Tiwari, Vijay, Weichenhan, Dieter, Benner, Axel, Radlwimmer, Bernhard, Zentgraf, Hanswalter, Wiemann, Stefan, Rippe, Karsten, Plass, Christoph, Döhner, Hartmut, Lichter, Peter, Stilgenbauer, Stephan, Mertens, Daniel

“…Non-coding RNAs are much more common than previously thought. However, for the vast majority of non-coding RNAs, the cellular function remains enigmatic. The…”
Get full text

Outcome Prediction in Pediatric Medulloblastoma Based on DNA Copy-Number Aberrations of Chromosomes 6q and 17q and the MYC and MYCN Loci by PFISTER, Stefan, REMKE, Marc, KULOZIK, Andreas, REIFENBERGER, Guido, RUTKOWSKI, Stefan, WIESTLER, Otmar D, RADLWIMMER, Bernhard, SCHEURLEN, Wolfram, LICHTER, Peter, KORSHUNOV, Andrey, BENNER, Axel, MENDRZYK, Frank, TOEDT, Grischa, FELSBERG, Jörg, WITTMANN, Andrea, DEVENS, Frauke, GERBER, Nicolas U, JOOS, Stefan

“…Medulloblastoma is the most common malignant brain tumor in children. Current treatment decisions are based on clinical variables. Novel tumor-derived…”
Get full text

BCAT1 redox function maintains mitotic fidelity by Francois, Liliana, Boskovic, Pavle, Knerr, Julian, He, Wei, Sigismondo, Gianluca, Schwan, Carsten, More, Tushar H., Schlotter, Magdalena, Conway, Myra E., Krijgsveld, Jeroen, Hiller, Karsten, Grosse, Robert, Lichter, Peter, Radlwimmer, Bernhard

Get full text

The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation by Liu, Hai-Kun, Wang, Ying, Belz, Thorsten, Bock, Dagmar, Takacs, Andrea, Radlwimmer, Bernhard, Barbus, Sebastian, Reifenberger, Guido, Lichter, Peter, Schütz, Günther

“…Malignant gliomas are the most common primary brain tumors, and are associated with frequent resistance to therapy as well as poor prognosis. Here we…”
Get full text

LGR5 is a Marker of Poor Prognosis in Glioblastoma and is Required for Survival of Brain Cancer Stem-Like Cells by Nakata, Susumu, Campos, Benito, Bageritz, Josephine, Lorenzo Bermejo, Justo, Becker, Natalia, Engel, Felix, Acker, Till, Momma, Stefan, Herold-Mende, Christel, Lichter, Peter, Radlwimmer, Bernhard, Goidts, Violaine

“…In various types of cancers including glioblastoma, accumulating evidence show the existence of cancer stem‐like cells (CSCs), characterized by stem cell…”
Get full text