Search Results - "RABINOVITCH, Peter"

Healthy aging: The ultimate preventative medicine by Kaeberlein, Matt, Rabinovitch, Peter S., Martin, George M.

“…Age is the greatest risk factor for nearly every major cause of mortality in developed nations. Despite this, most biomedical research focuses on individual…”
Get full text

The Aging Heart by Chiao, Ying Ann, Rabinovitch, Peter S

“…Aging results in progressive deteriorations in the structure and function of the heart and is a dominant risk factor for cardiovascular diseases, the leading…”
Get full text

Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and Nuclear Factor-κB–Mediated Inflammation in Macrophages by Wang, Ying, Wang, Gary Z, Rabinovitch, Peter S, Tabas, Ira

“…RATIONALE:Mitochondrial oxidative stress (mitoOS) has been shown to correlate with the progression of human atherosclerosis. However, definitive cell…”
Get full text

mTOR is a key modulator of ageing and age-related disease by Johnson, Simon C., Rabinovitch, Peter S., Kaeberlein, Matt

“…Many experts in the biology of ageing believe that pharmacological interventions to slow ageing are a matter of 'when' rather than 'if'. A leading target for…”
Get full text

Mitochondria and Cardiovascular Aging by Dai, Dao-Fu, Rabinovitch, Peter S, Ungvari, Zoltan

“…Old age is a major risk factor for cardiovascular diseases. Several lines of evidence in experimental animal models have indicated the central role of…”
Get full text

The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response by Puente, Bao N., Kimura, Wataru, Muralidhar, Shalini A., Moon, Jesung, Amatruda, James F., Phelps, Kate L., Grinsfelder, David, Rothermel, Beverly A., Chen, Rui, Garcia, Joseph A., Santos, Celio X., Thet, SuWannee, Mori, Eiichiro, Kinter, Michael T., Rindler, Paul M., Zacchigna, Serena, Mukherjee, Shibani, Chen, David J., Mahmoud, Ahmed I., Giacca, Mauro, Rabinovitch, Peter S., Asaithamby, Aroumougame, Shah, Ajay M., Szweda, Luke I., Sadek, Hesham A.

“…The mammalian heart has a remarkable regenerative capacity for a short period of time after birth, after which the majority of cardiomyocytes permanently exit…”
Get full text

Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy by Song, Moshi, Chen, Yun, Gong, Guohua, Murphy, Elizabeth, Rabinovitch, Peter S, Dorn, Gerald W

“…RATIONALE:Mitochondrial reactive oxygen species (ROS) are implicated in aging, chronic degenerative neurological syndromes, and myopathies. On the basis of…”
Get full text

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy by Dai, Dao-Fu, MD, PhD, Chen, Tony, BS, Szeto, Hazel, MD, PhD, Nieves-Cintrón, Madeline, PhD, Kutyavin, Vassily, BS, Santana, Luis F., PhD, Rabinovitch, Peter S., MD, PhD

“…Objectives We investigated the effect of reducing mitochondrial oxidative stress by the mitochondrial-targeted antioxidant peptide SS-31 in hypertensive…”
Get full text

Mitochondrial protein interaction landscape of SS-31 by Chavez, Juan D., Tang, Xiaoting, Campbell, Matthew D., Reyes, Gustavo, Kramer, Philip A., Stuppard, Rudy, Keller, Andrew, Zhang, Huiliang, Rabinovitch, Peter S., Marcinek, David J., Bruce, James E.

“…Mitochondrial dysfunction underlies the etiology of a broad spectrum of diseases including heart disease, cancer, neurodegenerative diseases, and the general…”
Get full text

Cardiac aging: from molecular mechanisms to significance in human health and disease by Dai, Dao-Fu, Chen, Tony, Johnson, Simon C, Szeto, Hazel, Rabinovitch, Peter S

“…Cardiovascular diseases (CVDs) are the major causes of death in the western world. The incidence of cardiovascular disease as well as the rate of…”
Get more information

Mitochondrial dysfunction in cardiac aging by Tocchi, Autumn, Quarles, Ellen K., Basisty, Nathan, Gitari, Lemuel, Rabinovitch, Peter S.

“…Cardiovascular diseases are the leading cause of death in most developed nations. While it has received the least public attention, aging is the dominant risk…”
Get full text

Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte by Zhang, Huiliang, Alder, Nathan N, Wang, Wang, Szeto, Hazel, Marcinek, David J, Rabinovitch, Peter S

“…Aging-associated diseases, including cardiac dysfunction, are increasingly common in the population. However, the mechanisms of physiologic aging in general,…”
Get full text

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome by Johnson, Simon C., Yanos, Melana E., Kayser, Ernst-Bernhard, Quintana, Albert, Sangesland, Maya, Castanza, Anthony, Uhde, Lauren, Hui, Jessica, Wall, Valerie Z., Gagnidze, Arni, Oh, Kelly, Wasko, Brian M., Ramos, Fresnida J., Palmiter, Richard D., Rabinovitch, Peter S., Morgan, Philip G., Sedensky, Margaret M., Kaeberlein, Matt

“…Mitochondrial dysfunction contributes to numerous health problems, including neurological and muscular degeneration, cardiomyopathies, cancer, diabetes, and…”
Get full text

Cardiac Aging in Mice and Humans: The Role of Mitochondrial Oxidative Stress by Dai, Dao-Fu, Rabinovitch, Peter S

“…Age is a major risk factor for cardiovascular diseases, not only because it prolongs exposure to several other cardiovascular risks, but also owing to…”
Get full text

A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA by Sanchez-Contreras, Monica, Sweetwyne, Mariya T, Kohrn, Brendan F, Tsantilas, Kristine A, Hipp, Michael J, Schmidt, Elizabeth K, Fredrickson, Jeanne, Whitson, Jeremy A, Campbell, Matthew D, Rabinovitch, Peter S, Marcinek, David J, Kennedy, Scott R

“…Abstract Mutations in mitochondrial DNA (mtDNA) cause maternally inherited diseases, while somatic mutations are linked to common diseases of aging. Although…”
Get full text

Treatment with the mitochondrial‐targeted antioxidant peptide SS‐31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice by Tarantini, Stefano, Valcarcel‐Ares, Noa M., Yabluchanskiy, Andriy, Fulop, Gabor A., Hertelendy, Peter, Gautam, Tripti, Farkas, Eszter, Perz, Aleksandra, Rabinovitch, Peter S., Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan

“…Summary Moment‐to‐moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance of healthy cognitive function…”
Get full text

Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart by Dai, Dao‐Fu, Karunadharma, Pabalu P., Chiao, Ying A., Basisty, Nathan, Crispin, David, Hsieh, Edward J., Chen, Tony, Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Beyer, Richard P., MacCoss, Michael J., Rabinovitch, Peter S.

“…Summary Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin (mTOR) signaling, thereby regulating metabolism and…”
Get full text

DNA flow cytometry for detection of genomic instability as a cancer precursor in the gastrointestinal tract by Choi, Won-Tak, Rabinovitch, Peter S

“…One of the earliest applications of flow cytometry was the measurement of DNA content in cells. This method is based on the ability to stain DNA in a…”
Get full text

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice by Chiao, Ying Ann, Zhang, Huiliang, Sweetwyne, Mariya, Whitson, Jeremy, Ting, Ying Sonia, Basisty, Nathan, Pino, Lindsay K, Quarles, Ellen, Nguyen, Ngoc-Han, Campbell, Matthew D, Zhang, Tong, Gaffrey, Matthew J, Merrihew, Gennifer, Wang, Lu, Yue, Yongping, Duan, Dongsheng, Granzier, Henk L, Szeto, Hazel H, Qian, Wei-Jun, Marcinek, David, MacCoss, Michael J, Rabinovitch, Peter

“…Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial…”
Get full text

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival by Ramos, Fresnida J, Chen, Steven C, Garelick, Michael G, Dai, Dao-Fu, Liao, Chen-Yu, Schreiber, Katherine H, MacKay, Vivian L, An, Elroy H, Strong, Randy, Ladiges, Warren C, Rabinovitch, Peter S, Kaeberlein, Matt, Kennedy, Brian K

“…Mutations in LMNA, the gene that encodes A-type lamins, cause multiple diseases including dystrophies of the skeletal muscle and fat, dilated cardiomyopathy,…”
Get more information