Search Results - "R. Thomas Lumbers"

Evidence-Based Assessment of Genes in Dilated Cardiomyopathy by Jordan, Elizabeth, Peterson, Laiken, Ai, Tomohiko, Asatryan, Babken, Bronicki, Lucas, Brown, Emily, Celeghin, Rudy, Edwards, Matthew, Fan, Judy, Ingles, Jodie, James, Cynthia A., Jarinova, Olga, Johnson, Renee, Judge, Daniel P., Lahrouchi, Najim, Lekanne Deprez, Ronald H., Lumbers, R. Thomas, Mazzarotto, Francesco, Medeiros Domingo, Argelia, Miller, Rebecca L., Morales, Ana, Murray, Brittney, Peters, Stacey, Pilichou, Kalliopi, Protonotarios, Alexandros, Semsarian, Christopher, Shah, Palak, Syrris, Petros, Thaxton, Courtney, van Tintelen, J. Peter, Walsh, Roddy, Wang, Jessica, Ware, James, Hershberger, Ray E.

“…Each of the cardiomyopathies, classically categorized as hypertrophic cardiomyopathy, dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular…”
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The druggable genome and support for target identification and validation in drug development by Finan, Chris, Gaulton, Anna, Kruger, Felix A, Lumbers, R Thomas, Shah, Tina, Engmann, Jorgen, Galver, Luana, Kelley, Ryan, Karlsson, Anneli, Santos, Rita, Overington, John P, Hingorani, Aroon D, Casas, Juan P

“…Target identification (determining the correct drug targets for a disease) and target validation (demonstrating an effect of target perturbation on disease…”
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Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study by Hodgson, Sam, Huang, Qin Qin, Sallah, Neneh, Griffiths, Chris J, Newman, William G, Trembath, Richard C, Wright, John, Lumbers, R Thomas, Kuchenbaecker, Karoline, van Heel, David A, Mathur, Rohini, Martin, Hilary C, Finer, Sarah

“…Type 2 diabetes (T2D) is highly prevalent in British South Asians, yet they are underrepresented in research. Genes & Health (G&H) is a large, population study…”
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Machine learning for subtype definition and risk prediction in heart failure, acute coronary syndromes and atrial fibrillation: systematic review of validity and clinical utility by Banerjee, Amitava, Chen, Suliang, Fatemifar, Ghazaleh, Zeina, Mohamad, Lumbers, R Thomas, Mielke, Johanna, Gill, Simrat, Kotecha, Dipak, Freitag, Daniel F, Denaxas, Spiros, Hemingway, Harry

“…Machine learning (ML) is increasingly used in research for subtype definition and risk prediction, particularly in cardiovascular diseases. No existing ML…”
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Weight Change and the Onset of Cardiovascular Diseases: Emulating Trials Using Electronic Health Records by Katsoulis, Michail, Stavola, Bianca D., Diaz-Ordaz, Karla, Gomes, Manuel, Lai, Alvina, Lagiou, Pagona, Wannamethee, Goya, Tsilidis, Konstantinos, Lumbers, R. Thomas, Denaxas, Spiros, Banerjee, Amitava, Parisinos, Constantinos A., Batterham, Rachel, Patel, Riyaz, Langenberg, Claudia, Hemingway, Harry

“…Cross-sectional measures of body mass index (BMI) are associated with cardiovascular disease (CVD) incidence, but less is known about whether weight change…”
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Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals by Huang, Qin Qin, Sallah, Neneh, Dunca, Diana, Trivedi, Bhavi, Hunt, Karen A., Hodgson, Sam, Lambert, Samuel A., Arciero, Elena, Wright, John, Griffiths, Chris, Trembath, Richard C., Hemingway, Harry, Inouye, Michael, Finer, Sarah, van Heel, David A., Lumbers, R. Thomas, Martin, Hilary C., Kuchenbaecker, Karoline

“…Individuals with South Asian ancestry have a higher risk of heart disease than other groups but have been largely excluded from genetic research. Using data…”
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A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service by Kuan, Valerie, Denaxas, Spiros, Gonzalez-Izquierdo, Arturo, Direk, Kenan, Bhatti, Osman, Husain, Shanaz, Sutaria, Shailen, Hingorani, Melanie, Nitsch, Dorothea, Parisinos, Constantinos A, Lumbers, R Thomas, Mathur, Rohini, Sofat, Reecha, Casas, Juan P, Wong, Ian C K, Hemingway, Harry, Hingorani, Aroon D

“…To effectively prevent, detect, and treat health conditions that affect people during their lifecourse, health-care professionals and researchers need to know…”
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Data-driven identification of ageing-related diseases from electronic health records by Kuan, Valerie, Fraser, Helen C., Hingorani, Melanie, Denaxas, Spiros, Gonzalez-Izquierdo, Arturo, Direk, Kenan, Nitsch, Dorothea, Mathur, Rohini, Parisinos, Constantinos A., Lumbers, R. Thomas, Sofat, Reecha, Wong, Ian C. K., Casas, Juan P., Thornton, Janet M., Hemingway, Harry, Partridge, Linda, Hingorani, Aroon D.

“…Reducing the burden of late-life morbidity requires an understanding of the mechanisms of ageing-related diseases (ARDs), defined as diseases that accumulate…”
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Estimating the Effect of Reduced Attendance at Emergency Departments for Suspected Cardiac Conditions on Cardiac Mortality During the COVID-19 Pandemic by Katsoulis, Michail, Gomes, Manuel, Lai, Alvina G., Henry, Albert, Denaxas, Spiros, Lagiou, Pagona, Nafilyan, Vahe, Humberstone, Ben, Banerjee, Amitava, Hemingway, Harry, Lumbers, R. Thomas

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Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health records by Katsoulis, Michail, Lai, Alvina G, Diaz-Ordaz, Karla, Gomes, Manuel, Pasea, Laura, Banerjee, Amitava, Denaxas, Spiros, Tsilidis, Kostas, Lagiou, Pagona, Misirli, Gesthimani, Bhaskaran, Krishnan, Wannamethee, Goya, Dobson, Richard, Batterham, Rachel L, Kipourou, Dimitra-Kleio, Lumbers, R Thomas, Wen, Lan, Wareham, Nick, Langenberg, Claudia, Hemingway, Harry

“…Targeted obesity prevention policies would benefit from the identification of population groups with the highest risk of weight gain. The relative importance…”
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Rationale and design of the THIRST Alert feasibility study: a pragmatic, single-centre, parallel-group randomised controlled trial of an interruptive alert for oral fluid restriction in patients treated with intravenous furosemide by Chen, Yang, Shah, Anoop, Jani, Yogini, Higgins, Daniel, Saleem, Nausheen, Chafer, Kris, Sydes, Matthew Robert, Asselbergs, Folkert W, Lumbers, R Thomas

“…IntroductionAcute heart failure (HF) is a major cause of unplanned hospitalisation characterised by excess body water. A restriction in oral fluid intake is…”
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A genetic model of ivabradine recapitulates results from randomized clinical trials by Legault, Marc-André, Sandoval, Johanna, Provost, Sylvie, Barhdadi, Amina, Lemieux Perreault, Louis-Philippe, Shah, Sonia, Lumbers, R Thomas, de Denus, Simon, Tyl, Benoit, Tardif, Jean-Claude, Dubé, Marie-Pierre

“…Naturally occurring human genetic variants provide a valuable tool to identify drug targets and guide drug prioritization and clinical trial design. Ivabradine…”
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Unraveling the relationships between alpha- and beta-adrenergic modulation and the risk of heart failure by Baudier, Claire, Fougerousse, Françoise, Asselbergs, Folkert W., Guedj, Mickael, Komajda, Michel, Kotecha, Dipak, Thomas Lumbers, R., Schmidt, Amand F., Tyl, Benoît

“…BackgroundThe effects of α and ß adrenergic receptor modulation on the risk of developing heart failure (HF) remains uncertain due to a lack of randomized…”
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Transforming and evaluating electronic health record disease phenotyping algorithms using the OMOP common data model: a case study in heart failure by Papez, Vaclav, Moinat, Maxim, Payralbe, Stefan, Asselbergs, Folkert W, Lumbers, R Thomas, Hemingway, Harry, Dobson, Richard, Denaxas, Spiros

“…The aim of the study was to transform a resource of linked electronic health records (EHR) to the OMOP common data model (CDM) and evaluate the process in…”
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Life-Time Covariation of Major Cardiovascular Diseases: A 40-Year Longitudinal Study and Genetic Studies by Lind, Lars, Sundström, Johan, Ärnlöv, Johan, Ingelsson, Martin, Henry, Albert, Lumbers, R. Thomas, Lampa, Erik

“…It is known that certain cardiovascular diseases (CVD) are associated, like atrial fibrillation and stroke. However, for other CVDs, the links and temporal…”
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Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction by Martin, Nicole, Manoharan, Karthick, Davies, Ceri, Lumbers, R Thomas

“…Beta-blockers and inhibitors of the renin-angiotensin-aldosterone system improve survival and reduce morbidity in people with heart failure with reduced left…”
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Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction by Martin, Nicole, Manoharan, Karthick, Thomas, James, Davies, Ceri, Lumbers, R Thomas

“…Beta-blockers and inhibitors of the renin-angiotensin aldosterone system improve survival and reduce morbidity in people with heart failure with reduced left…”
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Genetic and functional insights into the fractal structure of the heart by Meyer, Hannah V., Dawes, Timothy J. W., Serrani, Marta, Bai, Wenjia, Tokarczuk, Paweł, Cai, Jiashen, de Marvao, Antonio, Henry, Albert, Lumbers, R. Thomas, Gierten, Jakob, Thumberger, Thomas, Wittbrodt, Joachim, Ware, James S., Rueckert, Daniel, Matthews, Paul M., Prasad, Sanjay K., Costantino, Maria L., Cook, Stuart A., Birney, Ewan, O’Regan, Declan P.

“…The inner surfaces of the human heart are covered by a complex network of muscular strands that is thought to be a remnant of embryonic development 1 , 2 . The…”
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Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization by Henry, Albert, Gordillo-Marañón, María, Finan, Chris, Schmidt, Amand F., Ferreira, João Pedro, Karra, Ravi, Sundström, Johan, Lind, Lars, Ärnlöv, Johan, Zannad, Faiez, Mälarstig, Anders, Hingorani, Aroon D., Lumbers, R. Thomas

“…Heart failure (HF) is a highly prevalent disorder for which disease mechanisms are incompletely understood. The discovery of disease-associated proteins with…”
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Translating and evaluating historic phenotyping algorithms using SNOMED CT by Elkheder, Musaab, Gonzalez-Izquierdo, Arturo, Qummer Ul Arfeen, Muhammad, Kuan, Valerie, Lumbers, R Thomas, Denaxas, Spiros, Shah, Anoop D

“…Patient phenotype definitions based on terminologies are required for the computational use of electronic health records. Within UK primary care research…”
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